Nitroimidazole scaffold: a potential panacea for infectious diseases—a review
Discover ChemistryNitroimidazoles are five-membered heterocyclic ring systems in which the ‘’nitro’’ group is appended to either carbon 2 (benznidazole), 4 (pretomanid) or 5 (fexinidazole) of the imidazole ring.
Tshwanelo B. Matlala +3 more
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Structural Basis of 5-Nitroimidazole Antibiotic Resistance [PDF]
Journal of Biological Chemistry, 2004 Hanna-Kirsti S. Leiros +5 more
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Imidazoles I. N-Alkylation of 4(5)-Nitroimidazoles
Croatica Chemica Acta, 1981 N-Alkylation of 4(5)-nitroimidazoles la-d with 2-chloroethylacetamide in acetic acid was studied. Time dependent amounts of the starting compounds 1, as well as of the two series of isomeric products 2a-d and 3a-d were monitored by preparative chromatography.
Crnić, Z., Glunčić, B.
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Hydrolysis of tinidazole : Analytical methods and degradation kinetics [PDF]
, 2003 Salo, Jukka-Pekka K.
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Anti-toxoplasma activity and DNA-binding of copper(II) and zinc(II) coordination compounds with 5-nitroimidazole-based ligands. [PDF]
J Biol Inorg ChemNavarro-Peñaloza R +7 more
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ObjectivesMetronidazole and tinidazole are effective treatments for most patients with trichomoniasis but not for individuals who are infected with very resistant strains of Trichomonas vaginalis or persons with hypersensitivity to the 5-nitroimidazole ...
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Pyruvate:ferredoxin oxidoreductase and thioredoxin reductase are involved in 5-nitroimidazole activation while flavin metabolism is linked to 5-nitroimidazole resistance in Giardia lamblia. [PDF]
J Antimicrob Chemother, 2011 Leitsch D +8 more
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Exploring CPP Enhanced Hypoxia Targeting: An Approach Using Radiolabeled 2-nitroimidazole TAT Conjugate. [PDF]
Drug Dev ResMittal S +4 more
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Synthesis of a new class of carbon–bonded anionic sigma complexes with 1,3-dimethyl-2,6-dioxo-5-(2,4,6-trinitrophenyl)-1,2,3,6-tetrahydropyrimidin-4-olate moiety as insensitive high energy density materials –– implications from impact sensitivity and thermal testings [PDF]
, 2015 core +1 more source