Results 111 to 120 of about 88,028,942 (209)

Nitroimidazole resistance in Helicobacter pylori

, 2000
The efficacy of a nitroimidazole-containing regimen for the treatment of Helicobacter pylori infection is decreased by nitroimidazole resistance. Nitroimidazoles are metabolized by H.
Van der Wouden, EJ, Kleibeuker, JH, Thijs, JC, Van Zwet, AA   +3 more
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Site selective fragmentation of halopyrimidines and nitroimidazole compounds

, 2016
Site selective fragmentation of halopyrimidines and nitroimidazole ...
Bolognesi Paola
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Characterising the binding of 2-nitroimidazole : a proton NMR study

, 2017
Tumor hypoxia is known to limit the effectiveness of current radiotherapy treatments, and is of significant interest in oncology [1]. Conventionally, tumor hypoxia has been quantified through electrode measurements of intratumoral pO2 [2].
Wijesekera, Nadeeja (S32280), Gupta, Abhishek (R18354), Zheng, Gang (R13962), Price, William S. (R10381), Torres, Allan M. (R11665), Willis, Scott A. (R17512)   +5 more
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The mechanism of action of new 5-nitroimidazole drugs which are effective against metronidazole-resistant Giardia

We have discovered new 5-nitroimidazole drugs which can overcome giardial resistance to metronidazole, the most prescribed 5-nitroimidazole drug to treat giardiasis.

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Probing 5-Nitroimidazole-Triazole Hybrids as Potential Anti-Kinetoplastid Agents: Synthesis and In Vitro Efficacy. [PDF]

ChemMedChem
Ferreira L, Badenhorst GD, Aucamp J, Suganuma K, N'Da DD.   +4 more
europepmc   +1 more source

Structure-enabled enhancement of potency in a metronidazole-benznidazole hybrid: design, synthesis, and evaluation of antitrypanosomal activity of a benzylamide-linked 5-nitroimidazole. [PDF]

Front Pharmacol
Velez ASMM, Chaves OA, Costa T, Serpa C, Borges JM, Freire-de-Lima CG, Decote-Ricardo D, Lima MEF.   +7 more
europepmc   +1 more source

Structural Evaluation of a Nitroreductase Engineered for Improved Activation of the 5-Nitroimidazole PET Probe SN33623. [PDF]

Int J Mol Sci
Sharrock AV, Mumm JS, Williams EM, Čėnas N, Smaill JB, Patterson AV, Ackerley DF, Bagdžiūnas G, Arcus VL.   +8 more
europepmc   +1 more source

Anti-toxoplasma activity and DNA-binding of copper(II) and zinc(II) coordination compounds with 5-nitroimidazole-based ligands. [PDF]

J Biol Inorg Chem
Navarro-Peñaloza R, Anacleto-Santos J, Rivera-Fernández N, Sánchez-Bartez F, Gracia-Mora I, Caballero AB, Gamez P, Barba-Behrens N.   +7 more
europepmc   +1 more source

Structural Basis of 5-Nitroimidazole Antibiotic Resistance [PDF]

Journal of Biological Chemistry, 2004
Hanna-Kirsti S. Leiros, Sigrid Kozielski-Stuhrmann, Ulrike Kapp, Laurent Terradot, Gordon A. Leonard, Seán M. McSweeney   +5 more
openaire   +1 more source

The binding of 4-nitroimidazole to metmyoglobin : ionic strength and pH dependence of the association rate constant

, 1981
4-Nitroimidazole binding to horse heart metmyoglobin was studied as a function of pH and ionic strength. The pKa of 4- nitroimidazole was also studied as a function of ionic strength.
Taylor, Kevin C.
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