European Journal of Medicinal Chemistry ReportsThe synthesis and evaluation of the biological activity of a series of 5-nitroimidazole hybrids is described. The structures of the synthesized hybrids were confirmed by spectral analysis FT-IR, 1H NMR, 13C NMR, MS, and by Elemental Analysis.
Miguel A. Rodríguez +8 more
doaj +1 more source
SynOpen, 2017 The first prospective fluorinated PET tracers for imaging hypoxia obtained via thiazolidine-ligation are reported. Three 1,2-thiol-amine linkers were combined with four different 2-nitroimidazole spacers via amide or urea bond formation.
M. Musolino, S. Dall’Angelo, M. Zanda
doaj +1 more source
Electron Scattering from 1-Methyl-5-Nitroimidazole: Cross-Sections for Modeling Electron Transport through Potential Radiosensitizers. [PDF]
Int J Mol Sci, 2023 Lozano AI +17 more
europepmc +1 more source
Nitroreductase (GlNR1) increases susceptibility of Giardia lamblia and Escherichia coli to nitro drugs [PDF]
, 2017 Objectives The protozoan parasite Giardia lamblia causes the intestinal disease giardiasis, which may lead to acute and chronic diarrhoea in humans and various animal species.
Müller, Joachim +2 more
core
Vitae, 2010 En este trabajo se realizó un estudio experimental y teórico sobre la N-alquilación de nitroimidazoles. Los N-alquil-2-metil-nitroimidazoles corresponden a moléculas con actividad biológica, que se obtienen por la reacción del 2-metil-5-nitroimidazol y ...
Constain SALAMANCA M +2 more
doaj
The use of lactic acid in combination with glycogen in the treatment of bacterial vaginosis [PDF]
Гинекология, 2015 The efficacy and safety of laktagel in the treatment of bacterial vaginosis was studied. Two components proved more effective in treatments based on the use of metronidazole and ornidazole with lactic acid, compared with the monotherapy group of 5 ...
E F Kira +6 more
doaj
Hypoxia imaging with 18F-FAZA PET/CT predicts radiotherapy response in esophageal adenocarcinoma xenografts [PDF]
, 2018 Background: Esophageal cancer is an aggressive disease with poor survival rates. A more patient-tailored approach based on predictive biomarkers could improve outcome. We aimed to predict radiotherapy (RT) response by imaging tumor hypoxia with F-18-FAZA
Brans, Boudewijn +10 more
core +2 more sources
Novel 8-nitroquinolin-2(1H)-ones as NTR-bioactivated antikinetoplastid molecules:Synthesis, electrochemical and SAR study [PDF]
, 2018 International audienceTo study the antiparasitic 8-nitroquinolin-2(1H)-one pharmacophore, a series of 31 derivatives was synthesized in 1-5 steps and evaluated in vitro against both Leishmania infantum and Trypanosoma brucei brucei.
Azas, Nadine +18 more
core +4 more sources
Successful Treatment of Persistent 5-Nitroimidazole-Resistant Trichomoniasis With an Extended Course of Oral Secnidazole Plus Intravaginal Boric Acid. [PDF]
Sex Transm Dis, 2023 McNeil CJ, Williamson JC, Muzny CA.
europepmc +1 more source
Characterization of Giardia lamblia WB C6 clones resistant to nitazoxanide and to metronidazole [PDF]
, 2017 Objectives The characterization of Giardia lamblia WB C6 strains resistant to metronidazole and to the nitro-thiazole nitazoxanide [2-acetolyloxy-N-(5-nitro 2-thiazolyl) benzamide] as the parent compound of thiazolides, a novel class of anti-infective ...
Hemphill, Andrew +3 more
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