Results 71 to 80 of about 88,028,942 (209)

Antimicrobial Resistance in Periodontal Disease: Rethinking Adjunctive Therapy in the Metagenomics Era, the Pressing Need for Precision Treatment and Periodontal Resistome Mapping

Journal of Cellular and Molecular Medicine, Volume 30, Issue 21, November 2026.
ABSTRACT Systemic antibiotics are effective when used as adjunctive therapy in the treatment of periodontitis; however, their use must be balanced against antimicrobial resistance, which is a major threat to global public health. This review provides an expert synthesis of the literature and a field‐level overview of antimicrobial resistance in ...
Meera Alghafri, Lindsey Edwards, David Moyes, Luigi Nibali   +3 more
wiley   +1 more source

Next-Generation Hypoxic Cell Radiosensitizers: Nitroimidazole Alkylsulfonamides

, 2018
Innovations in the field of radiotherapy such as stereotactic body radiotherapy, along with the advent of radio- immuno-oncology, herald new opportunities for classical oxygen-mimetic radiosensitizers.
Ralph J. Stevenson, Frederik B. Pruijn, Way Wua Wong, Robert F. Anderson, Qi, W, Stephen M. F. Jamieson, Muriel Bonnet, Wang, J, Bonnet, M, Lydia P. Liew, Kevin O. Hicks, Cho Rong Hong, Avik Shome, Wen Qi, Yongchuan Gu, Michael P. Hay, William R. Wilson, Jingli Wang, Hicks, KO, Liew, LP, Gu, Y, Wong, WW, Stevenson, RJ, Hay, MP, Anderson, RF, Wilson, WR, Hong, CR, Pruijn, FB, Jamieson, SMF, Shome, A   +29 more
core   +1 more source

An Attempt to Assign the NMR Spectra in 7-Methyl-and 7-Benzyl-substituted 7H-Purine 1-Oxides Using the ACD/Labs Software Package

Molecules, 2003
Commercially available 4-nitroimidazole can be transformed in a few simple steps into 4-aminoimidazoyl-5-carboximes, from which the respective purine mono-1-oxides may be synthesized. The N→O functionality in these products significantly changes the
Stanisław Ostrowski
doaj   +1 more source

Acid‐Stable Nitrofuran Triple Therapy With Rabeprazole and Amoxicillin Targeting Helicobacter pylori Infection

MedComm, Volume 7, Issue 10, October 2026.
Overview: Novel nitrofuran derivatives were developed and evaluated against Helicobacter pylori to overcome antibiotic resistance and inflammation. Methods and Findings: In vitro assays using H. pylori 60190 and PMSS1 strains demonstrated potent antibacterial activity, reduced bacterial adhesion, and inhibited cytokine release from gastric epithelial ...
Nagendran Tharmalingam, Kulandaisamy Arulsamy, Shaolei Lu, Sadhna Dhingra, Scott Goodrich, Joseph St Laurent, Gerald Jones, Eleftherios Mylonakis   +7 more
wiley   +1 more source

Empirical Meropenem Versus Piperacillin/Tazobactam for Critically Ill Adults With Sepsis: Feasibility of a Randomised Trial

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 9, October 2026.
ABSTRACT Background Meropenem and piperacillin/tazobactam are commonly used empirical antibiotics in critically ill adults with sepsis, but whether one is superior to the other is uncertain. Methods The Empirical Meropenem versus Piperacillin/Tazobactam for Adult Patients with Sepsis (EMPRESS) trial is an ongoing investigator‐initiated, randomised ...
Nick Frørup Meier, Morten Hylander Møller, Maj‐Brit Nørregaard Kjær, Fredrik Sjövall, Marie Warrer Munch, Benjamin Skov Kaas‐Hansen, Hans‐Christian Thorsen‐Meyer, Bodil Steen Rasmussen, Marie Helleberg, Frederik Boëtius Hertz, Theis Lange, Aksel Karl Georg Jensen, Lars Wiuff Andersen, Jakob Steen Andersen, Jens Michelsen, Lars Peter Kloster Andersen, Morten Heiberg Bestle, Anne Craveiro Brøchner, Theis Skovsgaard Itenov, Steffen Christensen, Ronni Thermann Reitz Plovsing, Klaus Ulrik Koch, Anders Møller, Olav Lilleholt Schjørring, Naia Bech Cranø, Kasper Vamdrup‐Andersen, Davide Placido, Tine Sylvest Meyhoff, Carl Thomas Anthon, Aske Tøgern, Milda Grigonyte‐Daraskeviciene, Zemira Engbakken, Anne Witte Kamstrup, Kis Rønn Uhre, Jehad Ahmad Barakji, Rikke Faebo Larsen, Anders Perner, Anders Granholm   +37 more
wiley   +1 more source

Molecularly Engineered Wing‐Shaped Azobenzene Memristors for Logic‐in‐Memory and Edge Visual Intelligence

Advanced Science, Volume 13, Issue 53, 24 September 2026.
Rational engineering of terminal substituents in symmetric azobenzene‐based molecules enables precise control over conformationally coupled charge‐transfer processes. This design yields tunable nonvolatile resistive memory behaviors, ranging from write‐once‐read‐many‐times (WORM) to rewritable switching.
Yanze Liu, Tao Han, Jiahui Ding, Hong Lian, Lingling Yao, Zhaoxin Xu, Xingyu Zhang, Shuanglong Wang, Jiangnan Xia, Tianchi Zhang, Weiwei Kang, Qingchen Dong   +11 more
wiley   +1 more source

Microbiome—pancreatic cancer crosstalk: From tumor biology to therapeutic intervention

iMetaOmics, Volume 3, Issue 3, September 2026.
The intratumoral microbiome acts as a critical regulator in pancreatic cancer progression and therapeutic resistance. This comprehensive review delineates the origins of pancreatic microbes, elucidates their multifaceted mechanisms in driving immune suppression, metabolic reprogramming, and stromal desmoplasia, and highlights the clinical potential of ...
Yuqin Xie, Jingyuan Ye, Sheng Wang, Maoyun Liu, Fengsheng Dai, Mingzhen Bai, Yi Wang, Athena Savoji, Yu Wang, Phillip B. Hylemon, Huiping Zhou, Hui Li, Dewei Li   +12 more
wiley   +1 more source

Advances in Organic Aggregates for Biomedical Phototheranostics

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
Organic aggregates offer aggregation‐regulated photophysical properties for biomedical phototheranostics, enabling enhanced fluorescence, stabilized room‐temperature phosphorescence, and efficient photoacoustic/photothermal responses. This review highlights molecular design strategies, excited‐state energy modulation, biomedical applications, and ...
Bowen Fu, Yayun Peng, Ting Cai
wiley   +1 more source

N 1-Substitution in 2-Methyl-4(5)-Nitroimidazole. II. [PDF]

, 1967
During the syntheses of some new derivatives of 2-methyl-4(5)nitroimidazole with potential antitrichomonal activity, we have noticed that the substitution on N 1 did not always depend on the pH of the medium, as it has been stated by Pyman1- 4 and ...
Slamnik, M., Oklobdžija, M ., Kolbah, D ., Kajfež, F., Fajdiga, T ., Šunjić, V .   +5 more
core   +1 more source

Reactions in Nitroimidazole and Methylnitroimidazole Triggered by Low-Energy (0–8 eV) Electrons

, 2015
International audienceLow-energy electrons (0–8 eV) effectively decompose 4-nitroimidazole (4NI) and the two methylated isomers 1-methyl-5-nitroimidazole and 1-methyl-4-nitroimidazole via dissociative electron attachment (DEA).
Feketeová, Linda, Denifl, Stephan, Puschnigg, Benjamin, Illenberger, Eugen, Tanzer, Katrin, Denifl, S., Tanzer, K., Feketeova, L., Scheier, P., Scheier, Paul, Illenberger, E., Puschnigg, B.   +11 more
core   +1 more source