Results 51 to 60 of about 88,028,942 (209)

Design, synthesis, reactivity, and biological activity of nitroimidazole derivatives and their copper(II) coordination compounds

Frontiers in Chemical Biology
In the last 60 years, the broad spectrum of activity of nitroimidazole derivatives against anaerobic bacteria, parasites, and protozoa has permitted their use as the first choice of treatment for many infectious diseases.
Walter Fugarolas, Lorena Reyes-Carmona, Bruno Landeros-Rivera, Argelia Almaguer-Flores, Norah Barba-Behrens   +4 more
doaj   +1 more source

Crystal structure of 1-(2-bromoethyl)-2-methyl-5-nitroimidazole, C6H8BrN3O2

Zeitschrift für Kristallographie - New Crystal Structures, 2006
C6H8BrN3O2, monoclinic, P121/a1 (no. 14), a = 6.3952(2) Å, b = 11.1267(3) Å, c = 12.0785(4) Å, β = 97.274(2)°, V = 852.6 Å3, Z = 4, Rgt(F) = 0.047, wRref(F2) = 0.128, T = 293 K.
Balliano T. L., Pereira M. A., De Simone C. A., Malta V. R. S., Velasquez N., Cioletti A. G, Goulart M. O. F.   +6 more
doaj   +1 more source

Efficacy of secnidazole in the treatment of trichomoniasis and vaginal dysbiosis

Медицинский совет, 2022
Introduction. Trichomoniasis is a vaginal infectious and inflammatory disease, which falls into the category of sexually transmissible nosological entities.
V. F. Bezhena, O. L. Molchanov, N. B. Lazareva, L. A. Galiullina, A. L. Poznyak   +4 more
doaj   +1 more source

Antibiotic‐mediated immune modulation in periodontitis

Periodontology 2000, EarlyView.
Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez, R. M. Arce, Camila Pinheiro Furquim, Cristiane Gonçalves, Alpdogan Kantarci, Magda Feres, Nidia C. Castro dos Santos   +6 more
wiley   +1 more source

A novel transformation of 2-dichloracetamido-1-methyl-5-nitroimidazole to 5-dichloroacetylimino-tetrahydroimidazo (4,5-c) pyrazoles

, 1980
2-Dichloracetamido-1-methyl-5-nitroimidazole undergoes novel cycloaddition with diazomethane to form 5-dichloracetylimino-tetrahydroimidazopyrazoles via 2-dichloracetylimino-1,3-dimethyl-5 ...
Shenoy, S. J., Sudarsanam, V., Rao, K. Rama, Nagarajan, K., S.J. Shenoy, K. Rama Rao, K. Nagarajan, V. Sudarsanam   +7 more
core   +1 more source

SYNTHESIS, TENTATIVE CHARACTERISATION AND ANTIMICROBIAL ACTIVITIES OF 1-ETHYL-2-METHYL-4-NITROIMIDAZOLE-5-THIOL AND ITS DERIVATIVES [PDF]

, 2019
The study is on the synthesis, characterization and antimicrobial activities of 1-ethyl-2-methyl-4-nitroimidazole-5-thiol and its derivatives. 5-chloro-1-ethyl-2-methylimidazole (2) was synthesized by reacting N, N-diethyloxamide (1) with PCl5. Compound (
Okpara, G.E., Owolabi, B.J., Ndibe, H.C.
core   +1 more source

Nitroimidazoles XIII. Synthesis of Substituted (1-Methyl-5-Nitro-2-Imidazolyl) Isoxazoles [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 1998
The beta0diketone derivatives of nitroimidazole were synthesized from the reaction of magnesium salt of beta-ketoaccids 3 with imidazolide 4. The raction of beta-diketones with hydroxylamine hydrochloride afforded either the isoxazoles or the 5-hydroxyl ...
Abbas Shafiee, Mohammad ALi Ebrahimzadeh
doaj  

Novel and emerging antimicrobial strategies in the management of oral infections

Periodontology 2000, EarlyView.
Abstract Background Antibiotics marked a pivotal turning point in human civilization, enhancing social interactions and extending human life expectancy. In addition to their success in treating systemic infectious diseases, they have significantly improved periodontal treatment outcomes as an adjunct therapy.
Ozge Unlu, Nil Yakar, Alpdogan Kantarci
wiley   +1 more source

EXPERIMENTAL AND THEORETICAL STUDY OF SHYNTESIS OF N-ALKYL-NITROIMIDAZOLES.

Vitae, 2010
In this work we realized and experimental and theoretical study of the N-alkylation of nitroimidazoles.The N-alkyl-2-methyl-nitroimidazoles correspond to biologically active molecules, obtained by reactionof 2-methyl-5-nitroimidazole and different alkyl ...
Constain SALAMANCA M., William TIZNADO V., Paula JARAMILLO G.   +2 more
doaj  

Structural simplification of the 3‐nitroimidazo[1,2‐a]pyridine antileishmanial pharmacophore: Design, synthesis, and antileishmanial activity of novel 2,4-disubstituted 5-nitroimidazoles

Heterocyclic Communications
As part of our ongoing antileishmanial structure–activity relationship study, a structural simplification of the 3‐nitroimidazo[1,2‐a]pyridine ring to a 5-nitroimidazole moiety was conducted.
Paoli-Lombardo Romain, Primas Nicolas, Hutter Sébastien, Castera-Ducros Caroline, Jacquet Inès, Verhaeghe Pierre, Azas Nadine, Rathelot Pascal, Vanelle Patrice   +8 more
doaj   +1 more source