Results 51 to 60 of about 14,177 (223)

Optimising hypoxia PET imaging and its applications in guiding targeted radiation therapy for non‐small cell lung cancer: a scoping review

Journal of Medical Radiation Sciences, Volume 72, Issue 1, Page 106-118, March 2025.
This review article reports that quantification of hypoxic volumes using PET in the pre‐radiation therapy setting is of prognostic value and indicative of treatment response in non‐small cell lung cancer. Abstract Introduction Non‐small cell lung cancer (NSCLC) is the leading cause of cancer‐related death. Definitive treatment includes chemotherapy and
Carol Marks, Michelle Leech
wiley   +1 more source

In vitro anti-parasitic activities of Pulicaria dysenterica and Lycopus europaeus methanolic extracts against Trichomonas gallinae [PDF]

, 2018
Introduction: Trichomonas gallinae is the causative agent of trichomoniasis in birds. Although metronidazole is now the drug of choice for treatment of this infection, several studies reported metronidazole-resistant strains of T. gallinae.
Nikpay, Ali., Soltani, maryam.
core   +2 more sources

Using 5-Nitroimidazole Derivatives against Neglected Tropical Protozoan Diseases: Systematic Review

Future Pharmacology
Neglected tropical diseases (NTDs) are a significant global health problem. Additionally, anti-protozoan treatments are toxic, and their therapeutic regimens require prolonged treatment times and high concentrations of the drugs.
Micheel M. Vichi-Ramírez, Edgar López-López, Catalina Soriano-Correa, Carolina Barrientos-Salcedo   +3 more
doaj   +1 more source

Synthesis, crystal structures and electrochemical properties of ferrocenyl imidazole derivatives

Heliyon, 2019
Six ferrocenyl imidazole derivatives substituted with -Cl, -NO2 and -CH3 on the 2-position of the 1H-imidazole ring have been synthesized. Of the six compounds, the di-substituted ferrocenes, i.e. compounds 4 (1,1′-ferrocenylmethyl(2-chloroimidazole)), 5
Ayomide H. Labulo, Bernard Omondi, Vincent O. Nyamori   +2 more
doaj   +1 more source

Boron‐10 carriers and their applications in boron neutron capture therapy

Precision Radiation Oncology, EarlyView.
Summary of different types of boron drugs. Abstract Boron neutron capture therapy (BNCT) has emerged as a promising therapeutic modality in cancer treatment, demonstrating the ability to selectively eliminate cancer cells through the 10B(n,α)7Li nuclear reaction with minimal side effects on normal tissues.
Dachao Tang, Mengqi Shi, Zhichen Mao, Weiya Chen, Xiaoling Li, Xiao Yan Zhao, Zhigang Liu, Xiao Xu   +7 more
wiley   +1 more source

A multivariate analysis on non-nucleoside HIV-1 reverse transcriptase inhibitors and resistance induced by mutation [PDF]

, 2004
This paper describes the use of multivariate statistical procedure PCA as a tool to explore the inhibitory activity of classes of NNRTIs against HIV-1 viruses (wild type and more frequent mutants, Y181C, V106A, K103N, L100I) and against RT enzyme.
Arranz, Bacheler, Balzarini, Buckheit, Campiani, Carbo, Clercq, Clercq, Corbett, Hajos, Huberty, Manly, Petropoulos, Silvestri, Tramontano, Xu, Zembower   +16 more
core   +1 more source

Nitroimidazoles XIII. Synthesis of Substituted (1-Methyl-5-Nitro-2-Imidazolyl) Isoxazoles [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 1998
The beta0diketone derivatives of nitroimidazole were synthesized from the reaction of magnesium salt of beta-ketoaccids 3 with imidazolide 4. The raction of beta-diketones with hydroxylamine hydrochloride afforded either the isoxazoles or the 5-hydroxyl ...
Abbas Shafiee, Mohammad ALi Ebrahimzadeh
doaj  

Activatable smart contrast agents for photoacoustic imaging

Smart Molecules, EarlyView.
This review highlights recent advances in smart activatable photoacoustic imaging (PAI) contrast agents, which dynamically modulate their optical properties in response to external stimuli or microenvironmental cues. It discusses their molecular design, activation mechanisms, biomedical applications, and future prospects for clinically tailored use ...
Donghyeon Oh, Jihye Lee, Suyoung Park, Juyoung Yoon, Won Jong Kim, Chulhong Kim   +5 more
wiley   +1 more source

Trichomonas vaginalis: Clinical relevance, pathogenicity and diagnosis [PDF]

Trichomonas vaginalis is the etiological agent of trichomoniasis, the most prevalent non-viral sexually transmitted disease worldwide. Trichomoniasis is a widespread, global health concern and occurring at an increasing rate.
Abdolrasouli A, Adu-sarkodie Y, Arroyo R, Asensio Sánchez T, Azevedo A, Bachmann LH, Bandea CI, Bastida-Corcuera FD, Beltrán NC, Bosserman EA, Brandelli CLC, Brown HL, Burch TA, Chapin K, Craw P, Crowell AL, Crucitti T, Cudmore SL, da Costa RF, Diamond LS, Draper D, El-Shazly AM, Fichorova RN, Fichorova RN, Fiori PL, Fiori PL, Fisher I, Fraga J, Francioli P, Garber G, Garcia A, Garcia AF, Garcia AF, Gardner WA, Glyn Hobbs, Goodman RP, Gould SB, Guenthner PC, Hanada H, Heine P, Helen Smalley, Helms DJ, Hobbs MM, Holter O, Huppert JS, Johnston VJ, Kengne P, Kingston MA, Kirkcaldy RD, Klein NJ, Knowles S, Krashin JW, Krieger H, Krieger JN, Krieger JN, Kulda J, Kummer S, Lee JJ, Leitsch D, Lisi PJ, Lodish H, Madico G, Marlowe EM, Mavedzenge SN, Meyer-Rath G, Mirmonsef P, Munoz C, Muzny CA, Nailor MD, Nanda N, Ng A, Nielsen MH, Niemz A, O'Hanlon DE, Pai NP, Parent KN, Patil M, Patricia Burke, Pearce DM, Pereira-Neves A, Petrin D, Poole DN, Rein M, Ribeiro KC, Rodriguez-Ortega M, Ross J, Rukasha I, Ryan CM, Ryu JS, Schneider RE, Schwebke JR, Schwebke JR, Schwebke JR, Schwebke JR, Sehgal R, Sherrard J, Simpson P, Smith LM, Sobel JD, Sood S, Soper D, Sorvillo F, Sorvillo F, Stark JR, Stary A, Stoner KA, Sutcliffe S, Swygard H, Taylor BD, Thomas Edwards, Twu O, Upcroft JA, Van Der Pol B, Vancini RG, Viitanen J, Watt RM, Wendel KA, Workowski KA, Yarlett N, Zhang ZF   +119 more
core   +1 more source

Structural simplification of the 3‐nitroimidazo[1,2‐a]pyridine antileishmanial pharmacophore: Design, synthesis, and antileishmanial activity of novel 2,4-disubstituted 5-nitroimidazoles

Heterocyclic Communications
As part of our ongoing antileishmanial structure–activity relationship study, a structural simplification of the 3‐nitroimidazo[1,2‐a]pyridine ring to a 5-nitroimidazole moiety was conducted.
Paoli-Lombardo Romain, Primas Nicolas, Hutter Sébastien, Castera-Ducros Caroline, Jacquet Inès, Verhaeghe Pierre, Azas Nadine, Rathelot Pascal, Vanelle Patrice   +8 more
doaj   +1 more source