Results 41 to 50 of about 88,028,942 (209)

Management of Periodontal Abscesses and Endodontic‐Periodontal Lesions—A Systematic Review

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim To evaluate the management of periodontal abscesses and endodontic‐periodontal lesions (EPLs). Methods Seven focused questions addressed outcomes such as pocket depth (PD), bleeding on probing (BOP), tooth loss or ovoid elevation. The literature search covered three electronic databases and manual sources for intervention studies.
Henrik Dommisch, Daniela Hoedke, Marina Dourou, Elena Calciolari, David Herrera, Selena Toma   +5 more
wiley   +1 more source

Efficient Synthesis of DNA Containing the Guanine Oxidation-Nitration Product 5-Guanidino-4-nitroimidazole:  Generation by a Postsynthetic Substitution Reaction

, 2016
A convertible nucleoside was synthesized and used to prepare the 2‘-deoxynucleoside of 5-guanidino-4-nitroimidazole, a putative in vivo product of the reaction of peroxynitrite with guanine.
William L. Neeley (2507212), Paul T. Henderson (847604), John M. Essigmann (357654)   +2 more
core   +1 more source

Autogenous Demineralized Dentin Graft–Based Strategies With or Without I‐PRF and Metronidazole for Ridge Preservation in Infected Sockets: A Randomized Clinical Trial

Journal of Periodontal Research, EarlyView.
This randomized controlled trial evaluated the efficacy of demineralized dentin graft (DDG) combined with injectable platelet‐rich fibrin (I‐PRF) and metronidazole (MTZ) versus DDG with or without I‐PRF in alveolar ridge preservation (ARP) of infected extraction sockets.
Mohamed Talaat Elbehwashy, Manal Mohamed Hosny, Ahmed Elfana, Heba Ahmed Saleh, Karim Fawzy El‐Sayed   +4 more
wiley   +1 more source

Nitroimidazole-induced chronic hepatitis

, 2001
Drug-induced chronic hepatitis is a rare pathological condition. There is no reported case with chronic hepatitis secondary to nitroimidazole use. We report a patient who developed nitroimidazole-induced chronic hepatitis following acute exacerbation of ...
Batur, Y, Gunsar, F, Yuce, G, Akarca, US, Karasu, Z, Ersoz, G   +5 more
core   +1 more source

Nitazoxanide and tizoxanide demonstrate high levels of in vitro activity against metronidazole-susceptible and metronidazole-resistant Trichomonas vaginalis clinical isolates

Microbiology Spectrum
Trichomonas vaginalis is the most common non-viral sexually transmitted infection worldwide. We compared the in vitro activity of the thiazolide nitazoxanide (NTZ) and its metabolite, tizoxanide (TIZ), with the activity of the Food and Drug ...
Keonte J. Graves, John C. Williamson, Jan Novak, Hemant K. Tiwari, W. Evan Secor, Christina A. Muzny   +5 more
doaj   +1 more source

5-Nitroimidazole refractory giardiasis is common in Matanzas, Cuba and effectively treated by secnidazole plus high-dose mebendazole or quinacrine:a prospective observational cohort study

, 2020
OBJECTIVE: To evaluate the effectiveness and tolerability of secnidazole combined with high-dose mebendazole for treatment of 5-nitroimidazole-resistant giardiasis.METHOD: Adults with microscopically verified Giardia intestinalis monoinfection attending ...
Cañete, Roberto, Herrera, Elaine, Rodríguez, Maylin, Kofoed, Poul-Erik, Noda, Amuri L, Brito, Katia, Ursing, Johan, Noda, AL, Ursing, J,, Canete, R, Brito, K, Herrera, E, Kofoed, P-E, Rodriguez, M   +13 more
core   +1 more source

Novel nitroimidazole alkylsulfonamides as hypoxic cell radiosensitisers

, 2014
A novel class of nitroimidazole alkylsulfonamides have been prepared and evaluated as hypoxia-selective cytotoxins and radiosensitisers. The sulfonamide side chain markedly influences the physicochemical properties of the analogues: lowering aqueous ...
Hicks, KO, Pruijn, FB, Wang, J, Bonnet, M, Hay, MP, Anderson, RF, Wilson, WR, Gu, Y, Hong, CR   +8 more
core   +1 more source

Synthesis, crystal structures and electrochemical properties of ferrocenyl imidazole derivatives

Heliyon, 2019
Six ferrocenyl imidazole derivatives substituted with -Cl, -NO2 and -CH3 on the 2-position of the 1H-imidazole ring have been synthesized. Of the six compounds, the di-substituted ferrocenes, i.e. compounds 4 (1,1′-ferrocenylmethyl(2-chloroimidazole)), 5
Ayomide H. Labulo, Bernard Omondi, Vincent O. Nyamori   +2 more
doaj   +1 more source

Pyruvate:ferredoxin oxidoreductase and thioredoxin reductase are involved in 5-nitroimidazole activation while flavin metabolism is linked to 5-nitroimidazole resistance in Giardia lamblia. [PDF]

J Antimicrob Chemother, 2011
The mechanism of action of, and resistance to, metronidazole in the anaerobic (or micro-aerotolerant) protozoan parasite Giardia lamblia has long been associated with the reduction of ferredoxin (Fd) by the enzyme pyruvate:ferredoxin oxidoreductase (PFOR) and the subsequent activation of metronidazole by Fd to toxic radical species.
Leitsch D, Burgess AG, Dunn LA, Krauer KG, Tan K, Duchêne M, Upcroft P, Eckmann L, Upcroft JA.   +8 more
europepmc   +4 more sources

Nitroimidazole Derivative Antimicrobial Drugs and Liver Injury

, 2023
Nitroimidazole derivative drugs have been widely used in clinical practice for many years. Metronidazole and ornidazole are nitroimidazole derivative antimicrobial drugs commonly used in treatment of various infections caused by anaerobic bacteria and ...
Uğur Balaban, Emre Kara, Kara, Emre, İnkaya, Ahmet Çağkan, Ahmet Çağkan İnkaya, Balaban, Uğur   +5 more
core   +1 more source