The redox-active drug metronidazole and thiol-depleting garlic compounds act synergistically in the protist parasite Spironucleus vortens [PDF]
, 2016 Spironucleus vortens is a protozoan parasite associated with significant mortalities in the freshwater angelfish, Pterophyllum scalare. Control of this parasite is especially problematic due to restrictions on the use of the drug of choice, metronidazole
Cable, Joanne +7 more
core +3 more sources
Drug repurposing: tolfenamic acid inactivates PrbP, a transcriptional accessory protein in liberibacter asiaticus [PDF]
, 2016 CLIBASIA_01510, PrbP, is a predicted RNA polymerase binding protein in Liberibacter asiaticus. PrbP was found to regulate expression of a small subset of ribosomal genes through interactions with the β-subunit of the RNA polymerase and a short, specific ...
Bojilova, Lora +6 more
core +7 more sources
Michael-type addition of azoles of broad-scale acidity to methyl acrylate
Beilstein Journal of Organic Chemistry, 2011 An optimisation of Michael-type addition of azole derivatives of broad-scale acidity – ranging from 5.20 to 15.00 pKa units – namely 4-nitropyrazole, 3,5-dimethyl-4-nitropyrazole, 4(5)-nitroimidazole, 4,5-diphenylimidazole, 4,5-dicyanoimidazole, 2-methyl-
Sławomir Boncel +3 more
doaj +1 more source
The crystal structure of 5-azido-1-methyl-4-nitroimidazole, C4H4O2N6
Zeitschrift für Kristallographie - New Crystal Structures, 2022 C4H4O2N6, monoclinic, P21/c (no. 14), a = 11.633(3) Å, b = 8.899(3) Å, c = 6.7638(18) Å, β = 105.216(12)°, V = 675.6(4) Å3, Z = 4, Rgt (F) = 0.0607, wRref (F 2) = 0.1617, T = 170 K.
Huipeng Zhao +4 more
doaj +1 more source
Journal of Mass Spectrometry, 2017 AbstractWe present here the photofragmentation patterns of doubly ionized 4(5)‐nitroimidazole and 1‐methyl‐5‐nitroimidazole. The doubly ionized state was created by core ionizing the C 1s orbitals of the samples, rapidly followed by Auger decay. Due to the recent development of nitroimidazole‐based radiosensitizing drugs, core ionization was selected ...
Eero Itälä +5 more
openaire +3 more sources
Helicobacter pylori eradication therapy to prevent gastric cancer in healthy asymptomatic infected individuals: systematic review and meta-analysis of randomised controlled trials [PDF]
, 2014 OBJECTIVES: To determine whether searching for Helicobacter pylori and treating with eradication therapy leads to a reduction in incidence of gastric cancer among healthy asymptomatic infected individuals.
Ford, AC +4 more
core +2 more sources
Iraqi Journal of Pharmaceutical Sciences, 2021 Secnidazole was linked with ciprofloxacin as mutual prodrugs to get antibiotics with broader spectrum of activity, improved physicochemical properties and given by single dose to improve patient’s compliance.
Marwah W. Khalid +2 more
doaj +1 more source
Management of trypanosomiasis and leishmaniasis [PDF]
, 2012 <p>Background: The current treatments for human African trypanosomiasis (HAT), Chagas disease and leishmaniasis (collectively referred to as the kinetoplastid diseases) are far from ideal but, for some, there has been significant recent progress ...
Alsford +39 more
core +2 more sources
Quality of medicines commonly used in the treatment of soil transmitted helminths and Giardia in Ethiopia: a nationwide survey [PDF]
, 2014 Background: The presence of poor quality medicines in the market is a global threat on public health, especially in developing countries. Therefore, we assessed the quality of two commonly used anthelminthic drugs [mebendazole (MEB) and albendazole (ALB)]
D'Hondt, Matthias +9 more
core +3 more sources
Journal of Integrated Health Sciences, 2016 Background: The development of resistant with the current antibiotics increases the need for discovery of more efficient drugs for the treatment of infections.
D G Desai +4 more
doaj +1 more source