Pharmaceuticals, 2022 Nitroimidazole represents one of the most essential and unique scaffolds in drug discovery since its discovery in the 1950s. It was K. Maeda in Japan who reported in 1953 the first nitroimidazole as a natural product from Nocardia mesenterica with ...
Parvinder Pal Singh +2 more
exaly +3 more sources
Journal of Mass Spectrometry, 2017 AbstractWe present here the photofragmentation patterns of doubly ionized 4(5)‐nitroimidazole and 1‐methyl‐5‐nitroimidazole. The doubly ionized state was created by core ionizing the C 1s orbitals of the samples, rapidly followed by Auger decay. Due to the recent development of nitroimidazole‐based radiosensitizing drugs, core ionization was selected ...
Eero Itälä +5 more
openaire +4 more sources
Using 5-Nitroimidazole Derivatives against Neglected Tropical Protozoan Diseases: Systematic Review
Future PharmacologyNeglected tropical diseases (NTDs) are a significant global health problem. Additionally, anti-protozoan treatments are toxic, and their therapeutic regimens require prolonged treatment times and high concentrations of the drugs.
Micheel M. Vichi-Ramírez +3 more
doaj +2 more sources
2-Hydroxymethyl-1-methyl-5-nitroimidazole, one siderophore inhibitor, occludes quorum sensing in Pseudomonas aeruginosa [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 Siderophore is necessary for the survival of microorganisms and is interregulated with quorum sensing (QS) systems. It is related to growth, proliferation, virulence, and other bacterial social activities as a virulence factor.
Lujun Yin +4 more
doaj +2 more sources
DYT-40, a novel synthetic 2-styryl-5-nitroimidazole derivative, blocks malignant glioblastoma growth and invasion by inhibiting AEG-1 and NF-κB signaling pathways. [PDF]
Sci Rep, 2016 Astrocyte elevated gene-1 (AEG-1) has been explored as a novel target for human glioma therapy, thus reflecting its potential contribution to gliomagenesis.
Zou M +10 more
europepmc +2 more sources
Transcriptomic Signatures of Trichomonas vaginalis Isolates That Exhibit Low, Intermediate, and High In Vitro Resistance to Metronidazole [PDF]
MicroorganismsAs part of efforts to identify genes associated with Trichomonas vaginalis resistance to 5-nitroimidazole drugs, thirty cryopreserved T. vaginalis isolates were revived and grown using Diamond’s TYM medium.
Keonte J. Graves +4 more
doaj +2 more sources
Molbank, 2023 In continuation of our research program to develop original synthetic methods using TDAE methodology on nitroheterocyclic substrates, we were able to generate for the first time a stable carbanion in position 2 of the 5-nitroimidazole scaffold.
Romain Paoli-Lombardo +5 more
doaj +1 more source
International journal of pharmaceutics, 2023 Bacterial vaginosis (BV) is a common dysbiosis of the human vaginal microbiota characterized by depletion of hydrogen peroxide and lactic acid-producing Lactobacillus bacteria and an overgrowth of certain facultative anaerobic bacteria.
Xinyu Zhao +4 more
semanticscholar +1 more source
Design, Synthesis and Anticancer Evaluation of Nitroimidazole Radiosensitisers
Molecules, 2023 The role of hypoxic tumour cells in resistance to radiotherapy, and in suppression of immune response, continues to endorse tumour hypoxia as a bona fide, yet largely untapped, drug target.
Lydia P. Liew +6 more
doaj +1 more source
Expanded therapeutic potential in activity space of next-generation 5-nitroimidazole antimicrobials with broad structural diversity. [PDF]
Proc Natl Acad Sci U S A, 2013 Miyamoto Y +13 more
europepmc +2 more sources