Results 31 to 40 of about 12,654,690 (210)
TLC–Densitometric Analysis of Selected 5-Nitroimidazoles
Processes, 2023 Metronidazole, ornidazole, tinidazole, and secnidazole are 5-nitroimidazoles. The purpose of this work was to propose a new economical TLC–densitometric method to evaluate the chemical stability of metronidazole, secnidazole, ornidazole, and tinidazole under stress conditions. A forced degradation study was performed on silica gel and aqueous solutions
openaire +2 more sources
Clinical Microbiology and Infection, 2019 OBJECTIVE To evaluate the effectiveness and tolerability of secnidazole combined with high-dose mebendazole for treatment of 5-nitroimidazole resistant giardiasis. METHOD Adults with microscopically verified Giardia intestinalis monoinfection attending
R. Cañete +6 more
semanticscholar +1 more source
Journal of Integrated Health Sciences, 2016 Background: The development of resistant with the current antibiotics increases the need for discovery of more efficient drugs for the treatment of infections.
D G Desai +4 more
doaj +1 more source
Coupling of C-nitro-NH-azoles with arylboronic acids. A route to N-aryl-C-nitroazoles
Beilstein Journal of Organic Chemistry, 2013 A method for the synthesis of N-aryl-C-nitroazoles is presented. A coupling reaction between variously substituted arylboronic acids and 3(5)-nitro-1H-pyrazole catalyzed by copper salt has been carried out in methanol in the presence of sodium hydroxide ...
Marta K. Kurpet +5 more
doaj +1 more source
Molecules, 2017 A one-pot regioselective bis-Suzuki-Miyaura or Suzuki-Miyaura/Sonogashira reaction on 2,4-dibromo-1-methyl-5-nitro-1H-imidazole under microwave heating was developed.
Fanny Mathias +7 more
doaj +1 more source
Compounds, 2023 The discovery of azomycin provided the major impulse for the systematic search for medicines showing activity against anaerobic protozoa. Nowadays, many other interesting applications have been found for nitroimidazoles as therapeutic agents.
Justyna Żwawiak, Lucjusz Zaprutko
doaj +1 more source
Synthesis of New Active Sulfones in the 5-Nitroimidazole Series
Molecules, 2002 We describe here the preparation of new 5-nitroimidazoles which are known to have an efficacy against metronidazole-susceptible and -resistant Giarda, Trichomonas, and Entamoeba spp. The multi-step synthesis uses electron transfer methodology.
Patrice Vanelle +2 more
doaj +1 more source
Journal of Clinical and Translational Science, 2022 OBJECTIVES/GOALS: 5-nitroimidazoles are the only FDA-approved medications for T. vaginalis treatment. Resistance has been observed in 5-10% of cases, but may be rising. We aimed to delineate mechanisms of resistance in isolates of T.
Keonte Graves +7 more
doaj +1 more source
Microbiome—pancreatic cancer crosstalk: From tumor biology to therapeutic intervention
iMetaOmics, EarlyView.The intratumoral microbiome acts as a critical regulator in pancreatic cancer progression and therapeutic resistance. This comprehensive review delineates the origins of pancreatic microbes, elucidates their multifaceted mechanisms in driving immune suppression, metabolic reprogramming, and stromal desmoplasia, and highlights the clinical potential of ...
Yuqin Xie +12 more
wiley +1 more source
Journal of Medical Radiation Sciences, Volume 72, Issue 1, Page 106-118, March 2025.This review article reports that quantification of hypoxic volumes using PET in the pre‐radiation therapy setting is of prognostic value and indicative of treatment response in non‐small cell lung cancer. Abstract Introduction Non‐small cell lung cancer (NSCLC) is the leading cause of cancer‐related death. Definitive treatment includes chemotherapy and
Carol Marks, Michelle Leech
wiley +1 more source