Identification of Trichomonas vaginalis 5-Nitroimidazole Resistance Targets [PDF]
Pathogens, 2023 Trichomonas vaginalis is the most common non-viral sexually transmitted infection. 5-nitroimidazoles are the only FDA-approved medications for T. vaginalis treatment.
Keonte J. Graves +6 more
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In Vitro Effect of 5-Nitroimidazole Drugs against Trichomonas vaginalis Clinical Isolates [PDF]
Microbiology Spectrum, 2022 Infections with the sexually transmitted parasite Trichomonas vaginalis are normally treated with metronidazole, but cure rates are suboptimal and recurrence rates following treatment are high.
Andile Mtshali +5 more
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Pharmaceuticals, 2022 Nitroimidazole represents one of the most essential and unique scaffolds in drug discovery since its discovery in the 1950s. It was K. Maeda in Japan who reported in 1953 the first nitroimidazole as a natural product from Nocardia mesenterica with ...
Parvinder Pal Singh +2 more
exaly +3 more sources
2-Hydroxymethyl-1-methyl-5-nitroimidazole, one siderophore inhibitor, occludes quorum sensing in Pseudomonas aeruginosa [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 Siderophore is necessary for the survival of microorganisms and is interregulated with quorum sensing (QS) systems. It is related to growth, proliferation, virulence, and other bacterial social activities as a virulence factor.
Lujun Yin +4 more
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Nitroimidazole - albendazole combination therapy, quinacrine use, and risk factors in nitroimidazole-refractory giardiasis: a prospective multicentre observational study [PDF]
BMC Infectious DiseasesBackground Nitroimidazole-refractory giardiasis is an increasing problem. We present data on efficacy of a treatment ladder and on clinical characteristics and assemblage types in nitroimidazole-refractory giardiasis.
Kristine Mørch +11 more
doaj +2 more sources
Practical and Metal-Free Synthesis of Novel Enantiopure Amides Containing the Potentially Bioactive 5-Nitroimidazole Moiety [PDF]
Molecules, 2016 We report here a practical and metal-free synthesis of novel enantiopure amides containing the drug-like 5-nitroimidazole scaffold. The first step was a metal-free diastereoselective addition of 4-(4-(chloromethyl)phenyl)-1,2-dimethyl-5-nitro-1H ...
Cédric Spitz +4 more
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Transcriptomic Signatures of Trichomonas vaginalis Isolates That Exhibit Low, Intermediate, and High In Vitro Resistance to Metronidazole [PDF]
MicroorganismsAs part of efforts to identify genes associated with Trichomonas vaginalis resistance to 5-nitroimidazole drugs, thirty cryopreserved T. vaginalis isolates were revived and grown using Diamond’s TYM medium.
Keonte J. Graves +4 more
doaj +2 more sources
Molbank, 2023 In continuation of our research program to develop original synthetic methods using TDAE methodology on nitroheterocyclic substrates, we were able to generate for the first time a stable carbanion in position 2 of the 5-nitroimidazole scaffold.
Romain Paoli-Lombardo +5 more
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Design, Synthesis and Anticancer Evaluation of Nitroimidazole Radiosensitisers
Molecules, 2023 The role of hypoxic tumour cells in resistance to radiotherapy, and in suppression of immune response, continues to endorse tumour hypoxia as a bona fide, yet largely untapped, drug target.
Lydia P. Liew +6 more
doaj +1 more source
Synthesis of N-7-Substituted Purines from Imidazole Precursors
Molecules, 1999 Synthesis of purines and purine mono-1-oxides from the respective 5-substituted 4-nitroimidazole derivatives is described. The commercially available 4-nitroimidazole, in a few simple steps (including Vicarious Nucleophilic Substitution of Hydrogen), was
Stanislaw Ostrowski
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