Identification of Trichomonas vaginalis 5-Nitroimidazole Resistance Targets [PDF]
Pathogens, 2023 Trichomonas vaginalis is the most common non-viral sexually transmitted infection. 5-nitroimidazoles are the only FDA-approved medications for T. vaginalis treatment.
Keonte J. Graves +6 more
doaj +4 more sources
In Vitro Effect of 5-Nitroimidazole Drugs against Trichomonas vaginalis Clinical Isolates [PDF]
Microbiology Spectrum, 2022 Infections with the sexually transmitted parasite Trichomonas vaginalis are normally treated with metronidazole, but cure rates are suboptimal and recurrence rates following treatment are high.
Andile Mtshali +5 more
doaj +2 more sources
Pharmaceuticals, 2022 Nitroimidazole represents one of the most essential and unique scaffolds in drug discovery since its discovery in the 1950s. It was K. Maeda in Japan who reported in 1953 the first nitroimidazole as a natural product from Nocardia mesenterica with ...
Rohit Singh +2 more
exaly +3 more sources
2-Hydroxymethyl-1-methyl-5-nitroimidazole, one siderophore inhibitor, occludes quorum sensing in Pseudomonas aeruginosa [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 Siderophore is necessary for the survival of microorganisms and is interregulated with quorum sensing (QS) systems. It is related to growth, proliferation, virulence, and other bacterial social activities as a virulence factor.
Lujun Yin +4 more
doaj +2 more sources
Management of Trichomoniasis in the Setting of 5-Nitroimidazole Hypersensitivity. [PDF]
Sex Transm Dis, 2021 Abstract Metronidazole and other 5-nitroimidazoles are the mainstay of Trichomonas vaginalis treatment, with few efficacious and safe treatment options available outside of this class. Patients with trichomoniasis and a history of a clinically confirmed hypersensitivity reaction to 5-nitroimidazoles present a management challenge for ...
Van Gerwen OT +4 more
europepmc +3 more sources
Practical and Metal-Free Synthesis of Novel Enantiopure Amides Containing the Potentially Bioactive 5-Nitroimidazole Moiety [PDF]
Molecules, 2016 We report here a practical and metal-free synthesis of novel enantiopure amides containing the drug-like 5-nitroimidazole scaffold. The first step was a metal-free diastereoselective addition of 4-(4-(chloromethyl)phenyl)-1,2-dimethyl-5-nitro-1H ...
Cédric Spitz +4 more
doaj +2 more sources
Nitazoxanide and tizoxanide demonstrate high levels of in vitro activity against metronidazole-susceptible and metronidazole-resistant Trichomonas vaginalis clinical isolates [PDF]
Microbiology SpectrumTrichomonas vaginalis is the most common non-viral sexually transmitted infection worldwide. We compared the in vitro activity of the thiazolide nitazoxanide (NTZ) and its metabolite, tizoxanide (TIZ), with the activity of the Food and Drug ...
Keonte J. Graves +5 more
doaj +2 more sources
Simultaneous determination of five nitroimidazole antimicrobials in pharmaceuticals using HPLC-ESM and QAMS methods [PDF]
BMC ChemistryA green, rapid, and simple HPLC-External standard method (ESM) and a quantitative analysis of multi- components with a single-marker (QAMS) method were established for the simultaneous determination of five nitroimidazole antimicrobials (Metronidazole ...
Baoxia Fang +3 more
doaj +2 more sources
Molbank, 2023 In continuation of our research program to develop original synthetic methods using TDAE methodology on nitroheterocyclic substrates, we were able to generate for the first time a stable carbanion in position 2 of the 5-nitroimidazole scaffold.
Romain Paoli-Lombardo +5 more
doaj +1 more source
Design, Synthesis and Anticancer Evaluation of Nitroimidazole Radiosensitisers
Molecules, 2023 The role of hypoxic tumour cells in resistance to radiotherapy, and in suppression of immune response, continues to endorse tumour hypoxia as a bona fide, yet largely untapped, drug target.
Lydia P. Liew +6 more
doaj +1 more source