Identification of Trichomonas vaginalis 5-Nitroimidazole Resistance Targets [PDF]
Pathogens, 2023 Trichomonas vaginalis is the most common non-viral sexually transmitted infection. 5-nitroimidazoles are the only FDA-approved medications for T. vaginalis treatment.
Keonte J. Graves +6 more
doaj +5 more sources
In Vitro Effect of 5-Nitroimidazole Drugs against Trichomonas vaginalis Clinical Isolates [PDF]
Microbiology Spectrum, 2022 Infections with the sexually transmitted parasite Trichomonas vaginalis are normally treated with metronidazole, but cure rates are suboptimal and recurrence rates following treatment are high.
Andile Mtshali +5 more
doaj +3 more sources
Management of Trichomoniasis in the Setting of 5-Nitroimidazole Hypersensitivity [PDF]
Sexually Transmitted Diseases, 2020 Abstract Metronidazole and other 5-nitroimidazoles are the mainstay of Trichomonas vaginalis treatment, with few efficacious and safe treatment options available outside of this class. Patients with trichomoniasis and a history of a clinically confirmed hypersensitivity reaction to 5-nitroimidazoles present a management challenge for ...
Olivia T, Van Gerwen +4 more
europepmc +4 more sources
Practical and Metal-Free Synthesis of Novel Enantiopure Amides Containing the Potentially Bioactive 5-Nitroimidazole Moiety [PDF]
Molecules, 2016 We report here a practical and metal-free synthesis of novel enantiopure amides containing the drug-like 5-nitroimidazole scaffold. The first step was a metal-free diastereoselective addition of 4-(4-(chloromethyl)phenyl)-1,2-dimethyl-5-nitro-1H ...
Cédric Spitz +4 more
doaj +3 more sources
Anti-toxoplasma activity and DNA-binding of copper(II) and zinc(II) coordination compounds with 5-nitroimidazole-based ligands. [PDF]
J Biol Inorg Chem, 2023 Tetrahedral copper(II) and zinc(II) coordination compounds from 5-nitroimidazole derivatives, viz . 1-(2-chloroethyl)-2-methyl-5-nitroimidazole (cenz) and ornidazole 1-(3-chloro-2-hydroxypropyl)-2-methyl-5-nitroimidazole (onz), were synthesized and ...
Navarro-Peñaloza R +7 more
europepmc +2 more sources
A systematic review of the literature on mechanisms of 5-nitroimidazole resistance in Trichomonas vaginalis. [PDF]
Parasitology, 2020 Background Trichomonas vaginalis is the most common non-viral sexually transmitted infection. 5-Nitroimidazoles [metronidazole (MTZ) and tinidazole (TDZ)] are FDA-approved treatments.
Graves KJ +5 more
europepmc +2 more sources
Pyruvate:ferredoxin oxidoreductase and thioredoxin reductase are involved in 5-nitroimidazole activation while flavin metabolism is linked to 5-nitroimidazole resistance in Giardia lamblia [PDF]
Journal of Antimicrobial Chemotherapy, 2011 The mechanism of action of, and resistance to, metronidazole in the anaerobic (or micro-aerotolerant) protozoan parasite Giardia lamblia has long been associated with the reduction of ferredoxin (Fd) by the enzyme pyruvate:ferredoxin oxidoreductase (PFOR) and the subsequent activation of metronidazole by Fd to toxic radical species.
David, Leitsch +8 more
europepmc +4 more sources
Design and Development of Small-Molecule Arylaldoxime/5-Nitroimidazole Hybrids as Potent Inhibitors of MARK4: A Promising Approach for Target-Based Cancer Therapy. [PDF]
ACS Omega, 2020 Microtubule affinity-regulating kinase 4 (MARK4), a member of the serine/threonine kinase family, is an emerging therapeutic target in anticancer drug discovery paradigm due to its involvement in regulation of microtubule dynamics, cell cycle regulation,
Peerzada MN +6 more
europepmc +2 more sources
Design, synthesis, in vitro inhibition and toxicological evaluation of human carbonic anhydrases I, II and IX inhibitors in 5-nitroimidazole series. [PDF]
J Enzyme Inhib Med Chem, 2020 With the aim to obtain novel compounds possessing both strong affinity against human carbonic anhydrases and low toxicity, we synthesised novel thiourea and sulphonamide derivatives 3, 4 and 10, and studied their in vitro inhibitory properties against ...
Aspatwar A +8 more
europepmc +2 more sources
Updates in trichomonas treatment including persistent infection and 5-nitroimidazole hypersensitivity. [PDF]
Curr Opin Infect Dis, 2020 Purpose of the review: The purpose of this review is to update information on treatment of T. vaginalis. Trichomonas vaginalis is estimated to be the most common treatable sexually transmitted infection (STI) In the world and is associated with poor ...
Muzny CA, Van Gerwen OT, Kissinger P.
europepmc +2 more sources