Results 61 to 70 of about 12,654,690 (210)

An Attempt to Assign the NMR Spectra in 7-Methyl-and 7-Benzyl-substituted 7H-Purine 1-Oxides Using the ACD/Labs Software Package

Molecules, 2003
Commercially available 4-nitroimidazole can be transformed in a few simple steps into 4-aminoimidazoyl-5-carboximes, from which the respective purine mono-1-oxides may be synthesized. The N→O functionality in these products significantly changes the
Stanisław Ostrowski
doaj   +1 more source

Preserved Spermatogenesis and Hormonal Function in Men Receiving a Pretomanid Regimen (BPaMZ) for Pulmonary Drug‐Resistant Tuberculosis

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 501-509, August 2026.
Pretomanid is a component of the World Health Organization‐recommended treatment regimen for drug‐resistant tuberculosis in patients aged ≥ 14 years. While preclinical rodent studies identified testicular toxicity as a potential clinical liability at elevated doses, no corresponding effects were observed in nonhuman primates nor clinical hormone ...
Pauline Howell, Antonio Lombardi, William Brumskine, Lali Mikiashvili, Kim Boekelheide, Joanna Moreira, Alda Holsta, Matthew Betteridge, Lindsay Thompson, Angela Crook, Paul Bruinenberg, Maria Beumont, Eugene Sun, Francesca Conradie   +13 more
wiley   +1 more source

Peptide‐based responsive molecular fluorescent probes for precision oncology

Responsive Materials, Volume 4, Issue 3, August 2026.
Peptide‐based responsive fluorescent probes have emerged as adaptive functional materials for precision tumor theranostics, combining tumor‐selective recognition, programmable stimulus responsiveness, and modular tunability. They enable high‐contrast imaging, intraoperative guidance, real‐time monitoring, and multimodal applications, while next ...
Xing Wang, Wen Liu, Jiahao Zhang, Wanqi Wang, Zhicheng Jin, Yuqi Tang, Quan Li   +6 more
wiley   +1 more source

Dual‐Targeting, Hybrid Antifungal Agents Targeting Candida albicans—An Overview

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
The selective, single‐targeting antifungal agents serve as the parent molecule(s) for the design of dual‐targeting, hybrid fungicidal agents and are discussed and compared, which enables the researchers to understand the logic for designing multi‐targeting new chemical entities (NCEs) that can exhibit dual‐sword attack on Candida albicans. ABSTRACT Due
Sarmistha Pal, Sriparna Pusti, Iftakhar Hussain Ansari, Sanchita Pradhan, Hritabrata Bhattacharya, Shuvradip Das   +5 more
wiley   +1 more source

Systemic Antibiotics in the Surgical Treatment of Peri‐Implantitis: Impact on the Salivary Microbiome

Journal of Clinical Periodontology, Volume 53, Issue 8, Page 1265-1277, August 2026.
ABSTRACT Aim To exploratorily compare the shifts in the salivary microbiome composition after administration of two combined systemic antibiotic regimens used in the surgical treatment of peri‐implantitis. Materials and Methods A subset of 27 patients treated surgically for peri‐implantitis with an adjunctive 7‐day course of systemic antibiotics were ...
Caroline Riben Grundström, Bodil Lund, Nagihan Bostanci, Angelika Silbereisen, Alexandra Pennhag, Ina Schuppe Koistinen, Yinghua Zha, Anastasios Damdimopoulos, Georgios N. Belibasakis, Margareta Hultin   +9 more
wiley   +1 more source

Probing 5‐Nitroimidazole‐Triazole Hybrids as Potential Anti‐Kinetoplastid Agents: Synthesis and In Vitro Efficacy

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
A series of 5‐nitroimidazole‐1,2,3‐triazole hybrids was synthesised and evaluated for antitrypanosomatid activity to assess their potential as treatments against leishmaniasis and trypanosomiasis. No notable in vitro activity against Leishmania was detected.
Liandi Ferreira, Gideon D. Badenhorst, Janine Aucamp, Keisuke Suganuma, David D. N’Da   +4 more
wiley   +1 more source

A Radioresistant‐Tumor‐Targeted Nanoparticle for X‐Ray‐Controlled Nitric Oxide Release to Potentiate Radiotherapy

Advanced Science, Volume 13, Issue 40, 17 July 2026.
The PBTN targets GRP78 and, upon X‐ray irradiation, generates ONOO− to induce immunogenic cell death, thereby activating CD8+ T cells and establishing a systemic antitumor immune response. ABSTRACT Nitric oxide (NO) treated radioresistant tumors by relieving hypoxia and blocking DNA repair, but its nonselective toxicity has precluded therapeutic use ...
Wanze Zhang, Xiaoyan Yin, Ting Wang, Hongfu Zhao, Zhipeng Zhao, Jinbao Wang, Cheng Tao, Xuanchu Ge, Yanze Li, Linlin Liu, Fuxin Xue   +10 more
wiley   +1 more source

The problem of resistant Trichomonas vaginalis to antiprotozoal drugs

Журнал инфектологии, 2014
This review presents recent data on the energy metabolism of Trichomonas vaginalis and ways the activation of metronidazole. The sensitivity of microorganisms to the 5-nitroimidazole by the presence of their enzyme systems, generating and transporting ...
A. L. Poznyak, S. S. Kozlov, R. V. Gudkov, Yu. F. Zaharkiv, S. N. Sidorchuk, O. L. Molchanov   +5 more
doaj   +1 more source

Effects of 1-(2-Nitro-1-Imidazolyl)-3-Methoxy-2-Propanol and 2-Methyl-5-Nitroimidazole-1-Ethanol Against Anaerobic and Aerobic Bacteria and Protozoa

Applied microbiology, 1969
1-(2-Nitro-1-imidazolyl)-3-methoxy-2-propanol (RO 7-0582) and 2-methyl-5-nitroimidazole-1-ethanol (Metronidazole), substances known to be potent trichomonacides, were shown to inhibit obligate anaerobic bacteria in vitro but were essentially without ...
H. Prince, E. Grunberg, E. Titsworth, W. Delorenzo   +3 more
semanticscholar   +1 more source

Synthesis, evaluation of the biological activity against Trypanosoma cruzi and Leishmania donovani. Preliminary in silico ADMET studies of 5-nitroimidazole derivatives

European Journal of Medicinal Chemistry Reports
The synthesis and evaluation of the biological activity of a series of 5-nitroimidazole hybrids is described. The structures of the synthesized hybrids were confirmed by spectral analysis FT-IR, 1H NMR, 13C NMR, MS, and by Elemental Analysis.
Miguel A. Rodríguez, Ali Mijoba, Nereida J. Parra-Giménez, Zuleyma Blanco, Katiuska Chávez, Alirica I. Suárez, Esteban Fernandez-Moreira, Hegira Ramírez, Jaime E. Charris   +8 more
doaj   +1 more source