Health Science Reports, Volume 9, Issue 5, May 2026.ABSTRACT Background and Aims Tuberculosis (TB) remains a major global health problem, and treatment progress is increasingly threatened by rising multidrug‐resistant tuberculosis (MDR‐TB). Delamanid (DLM), a nitroimidazole drug, has shown good efficacy and safety against both drug‐susceptible and drug‐resistant Mycobacterium tuberculosis (Mtb) strains.
Md. Mahmudul Islam +19 more
wiley +1 more source
Pharmacokinetics of secnidazole in healthy volunteers after single oral dose [PDF]
, 2010 Introduction: Secnidazole is an anti infective agent which belongs to the 5-nitroimidazole class. Method: The objective of the trial was to characterize the pharmacokinetics of secnidazole after oral administration of a 2g dose, as microgranules ...
A. Turcant +4 more
core +1 more source
Omeprazole as a Novel Treatment Option for Giardiasis in Cats
Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.In this study, cats with giardiasis were allocated to omeprazole, metronidazole, secnidazole or placebo groups and monitored from day 0 to 14. Omeprazole achieved a reduction in Giardia cyst shedding comparable to metronidazole and also demonstrated faster clinical improvement, indicating a potential therapeutic advantage.
Murat Kaan Durgut +6 more
wiley +1 more source
Guidelines for the treatment of bacterial vaginosis: focus on tinidazole [PDF]
, 2009 Laura J Dickey1, Michael D Nailor2,3, Jack D Sobel41Department of Pharmacy Services, Detroit Receiving Hospital, Detroit, MI, USA; 2University of Connecticut, School of Pharmacy, Storrs, CT, USA; 3Hartford Hospital, Department of Pharmacy, Hartford, CT ...
Laura J Dickey +2 more
core +1 more source
Multidrug-resistant Bacteroides fragilis group on the rise in Europe? [PDF]
, 2012 We report a case of multidrug-resistance (MDR) in a strain of Bacteroides fragilis from a blood culture and abdominal fluid in a Danish patient. The patient had not been travelling for several years and had not received antibiotics prior to the present ...
Hartmeyer, G N +3 more
core +1 more source
Antitrypanosomatid Pharmacomodulation at Position 3 of the 8-Nitroquinolin-2(1H)-one Scaffold Using Palladium-Catalysed Cross-Coupling Reactions [PDF]
, 2018 International audienceAn antikinetoplastid pharmacomodulation study at position 3 of the recently described hit molecule 3-bromo-8-nitroquinolin-2(1H)-one was conducted.
Abdoulaye, Mansour +14 more
core +4 more sources
Experimental comparison of 2-methylimidazole nitration by nitric acid and nitrate salts of alkali metals [PDF]
, 2015 The processes of nitration of 2-methylimidazole to produce 2-methyl-4(5)-nitroimidazole are considered in this paper. The processes of nitration by mixture of nitric and sulfuric acids and nitrate salts of alkali metals were compared.
Lyapunova, Maria V., Malkov, Victor S.
core +2 more sources
The problem of resistant Trichomonas vaginalis to antiprotozoal drugs
Журнал инфектологии, 2014 This review presents recent data on the energy metabolism of Trichomonas vaginalis and ways the activation of metronidazole. The sensitivity of microorganisms to the 5-nitroimidazole by the presence of their enzyme systems, generating and transporting ...
A. L. Poznyak +5 more
doaj +1 more source
Drug discovery for Chagas disease should consider Trypanosoma cruzi strain diversity. [PDF]
, 2014 This opinion piece presents an approach to standardisation of an important aspect of Chagas disease drug discovery and development: selecting Trypanosoma cruzi strains for in vitro screening.
Alejandro G Schijman +34 more
core +6 more sources
Development of a Rapid Chemical Identification System (RCIS) for the Detection of Fraudulently Labelled 5-nitroimidazole Products [PDF]
, 2010 Purpose: A simple, reliable and rapid chemical identification system (RCIS) consisting of three colour reactions based on the functional groups in the molecule and two TLC methods was developed for preliminary detection of the 5–nitroimidazole drugs ...
Awofisayo, OA, Awofisayo, OS, Eyen, NS
core +2 more sources