Results 81 to 90 of about 88,028,942 (209)

The problem of resistant Trichomonas vaginalis to antiprotozoal drugs

Журнал инфектологии, 2014
This review presents recent data on the energy metabolism of Trichomonas vaginalis and ways the activation of metronidazole. The sensitivity of microorganisms to the 5-nitroimidazole by the presence of their enzyme systems, generating and transporting ...
A. L. Poznyak, S. S. Kozlov, R. V. Gudkov, Yu. F. Zaharkiv, S. N. Sidorchuk, O. L. Molchanov   +5 more
doaj   +1 more source

Communication: "Position" does matter: the photofragmentation of the nitroimidazole isomers [PDF]

, 2016
A combined experimental and theoretical approach has been used to disentangle the fundamental mechanisms of the fragmentation of the three isomers of nitroimidazole induced by vacuum ultra-violet (VUV) radiation, namely, 4-, 5-, and 2-nitroimidazole. The
CARTONI, Antonella, Prince, K. C, B.P. Marinković, Marinković, B. P, Tošić, S, A. Cartoni, Chiarinelli, J, Markus, P, Bolognesi, P, P. Markus, A. R. Casavola, J. Chiarinelli, R. Richter, L. Avaldi, Borocci, S, S. Tošić, K.C. Prince, Sa'Adeh, H, Masič, M, Casavola, A. R, Richter, R, H. Sa’adeh, P. Bolognesi, S. Borocci, M. Masič, Avaldi, L., Prince KC, Avaldi L, Cartoni A, Borocci S, Richter R, Masic M, Bolognesi P, Markus P, Sa'adeh H, Casavola AR, Marinkovic BP, Tosic S, Chiarinelli J   +38 more
core   +1 more source

Efficacy and tolerability of quinacrine monotherapy and albendazole plus chloroquine combination therapy in nitroimidazole-refractory giardiasis: a tropnet study

, 2021
Background: Giardiasis failing nitroimidazole first-line treatment is an emerging problem in returning European travelers. We present data on the efficacy and tolerability of 2 second-line treatment regimens.
Bottieau, E., Rothe, Camilla, Schunk, Mirjam, Schunk, M., Sydow, V., Theunissen, C., Bottieau, Emmanuel, Neumayr, A., Sothmann, Peter, Van Esbroeck, Marjan, Rothe, C., Hatz, C., Kuenzli, E., Neumayr, Andreas, Hatz, Christoph, Theunissen, Caroline, Sothmann, P., Morch, Kristine, Sydow, Veronique, Mechain, Matthieu, Van Esbroeck, M., Perez, Manuel Jesus Soriano, Morch, K., Soriano Perez, M. J., Kuenzli, Esther, Mechain, M., Andreas Neumayr, Peter Sothmann, Kristine Mørch, Emmanuel Bottieau, Véronique Sydow, Mirjam Schunk, Camilla Rothe, Marjan Van Esbroeck, Matthieu Mechain, Esther Kuenzli, Caroline Theunissen, Manuel Jesús Soriano Pérez, Christoph Hatz   +38 more
core   +1 more source

Synthesis, evaluation of the biological activity against Trypanosoma cruzi and Leishmania donovani. Preliminary in silico ADMET studies of 5-nitroimidazole derivatives

European Journal of Medicinal Chemistry Reports
The synthesis and evaluation of the biological activity of a series of 5-nitroimidazole hybrids is described. The structures of the synthesized hybrids were confirmed by spectral analysis FT-IR, 1H NMR, 13C NMR, MS, and by Elemental Analysis.
Miguel A. Rodríguez, Ali Mijoba, Nereida J. Parra-Giménez, Zuleyma Blanco, Katiuska Chávez, Alirica I. Suárez, Esteban Fernandez-Moreira, Hegira Ramírez, Jaime E. Charris   +8 more
doaj   +1 more source

ESTUDIO EXPERIMENTAL Y TEÓRICO DE LA SÍNTESIS DE N-ALQUIL-NITROIMIDAZOLES EXPERIMENTAL AND THEORETICAL STUDY OF SHYNTESIS OF N-ALKYL-NITROIMIDAZOLES.

Vitae, 2010
En este trabajo se realizó un estudio experimental y teórico sobre la N-alquilación de nitroimidazoles. Los N-alquil-2-metil-nitroimidazoles corresponden a moléculas con actividad biológica, que se obtienen por la reacción del 2-metil-5-nitroimidazol y ...
Constain SALAMANCA M, William TIZNADO V, Paula JARAMILLO G   +2 more
doaj  

The use of lactic acid in combination with glycogen in the treatment of bacterial vaginosis [PDF]

Гинекология, 2015
The efficacy and safety of laktagel in the treatment of bacterial vaginosis was studied. Two components proved more effective in treatments based on the use of metronidazole and ornidazole with lactic acid, compared with the monotherapy group of 5 ...
E F Kira, N V Artymuk, A M Savicheva, S I Rogovskaya, A E Goushchin, T A Rumyantseva, O V Ivanova   +6 more
doaj  

Synthesis and Radiosynthesis of Prospective 2-Nitroimidazole Hypoxia­ PET Tracers via Thiazolidine Ligation with 5-Fluorodeoxyribose (FDR)

SynOpen, 2017
The first prospective fluorinated PET tracers for imaging hypoxia obtained via thiazolidine-ligation are reported. Three 1,2-thiol-amine linkers were combined with four different 2-nitroimidazole spacers via amide or urea bond formation.
M. Musolino, S. Dall’Angelo, M. Zanda
doaj   +1 more source

Electron Scattering from 1-Methyl-5-Nitroimidazole: Cross-Sections for Modeling Electron Transport through Potential Radiosensitizers. [PDF]

Int J Mol Sci, 2023
Lozano AI, Álvarez L, García-Abenza A, Guerra C, Kossoski F, Rosado J, Blanco F, Oller JC, Hasan M, Centurion M, Weber T, Slaughter DS, Mootheril DM, Dorn A, Kumar S, Limão-Vieira P, Colmenares R, García G.   +17 more
europepmc   +1 more source

Crystal structure of di-μ-chlorido-bis[chloridobis(1,2-dimethyl-5-nitro-1H-imidazole-κN3)copper(II)] acetonitrile disolvate

Acta Crystallographica Section E: Crystallographic Communications, 2016
1,2-Dimethyl-5-nitroimidazole (dimetridazole, dimet) is a compound that belongs to a class of nitroimidazole drugs that are effective at inhibiting the activity of certain parasites and bacteria. However, there are few reports that describe structures of
Patrick J. Quinlivan, Rita K. Upmacis
doaj   +1 more source

Successful Treatment of Persistent 5-Nitroimidazole-Resistant Trichomoniasis With an Extended Course of Oral Secnidazole Plus Intravaginal Boric Acid. [PDF]

Sex Transm Dis, 2023
McNeil CJ, Williamson JC, Muzny CA.
europepmc   +1 more source