Results 131 to 140 of about 12,654,690 (210)

Radiosensitization by Quaternary Salts of 5-nitroimidazole Derivatives

International Journal of Radiation Biology, 1989
The radiosensitizing effects of five newly synthesized quaternary salts of 5-nitroimidazole derivatives on the survival of TC-SV40 mammalian cells have been measured. A toxicity study was carried out in order to determine the concentrations to be used in the radiosensitizing experiments.
L, Santos, M C, Lopez Zumel, M V, Alvarez, M C, Izquierdo   +3 more
openaire   +2 more sources

Exploring new 5‐Nitroimidazole Derivatives as Potent Acetylcholinesterase and Butyrylcholinesterase Enzyme Inhibitors

Chemistry and Biodiversity
Discovering new compounds capable of inhibiting physiologically and metabolically significant drug targets or enzymes is of paramount importance in biological chemistry. With this aim, new 5‐nitroimidazole derivatives (1–4) were designed and synthesized,
Sule Gursoy, Doruk Satıcı, Burak Kuzu, Burçin Turkmenoglu, Esra Dilek, Oztekin Algul   +5 more
semanticscholar   +1 more source

Synthesis, structural and biological activity of N-substituted 2-methyl-4-/5-nitroimidazole derivatives

Journal of Molecular Structure, 2019
Two N-substituted 2-methyl-4-/5-nitroimidazole derivatives (3 & 4) have been synthesized by K2CO3 catalyzed reaction between 2-methyl-5-nitro-1H-imidazole (1) or metronidazole (2) and acrylonitrile.
Md Mushtaque, F. Avecilla, Ashanul Haque, Zafar Yab, M. A. Rizvi, Mohd Shahid Khan   +5 more
semanticscholar   +1 more source

Cross-resistance of trichomonads to 5-nitroimidazole-derivatives

Experientia, 1976
The strainT. foetus KV 1/M 100, a sub-strain ofT. foetus Kv 1, was made highly resistant to metronidazole by several passages in mice under increasing drug pressure. This drug resistance was accompained by a remarkable cross-resistance to all 5-nitroimidazole-derivatives tested in vitro and in vivo.
J G, Meingassner, H, Mieth
openaire   +2 more sources

A Convenient Synthesis of Highly Conjugated 5-Nitroimidazoles

HETEROCYCLES, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
Kamel Benakli, Thierry Terme, Jose Maldonado, Patrice Vanelle   +3 more
openaire   +1 more source

Genetics of Resistance of Bacteroides Species to 5-Nitroimidazole

Clinical Infectious Diseases, 1993
Thirty-three clinical isolates of Bacteroides strains with a moderate-to-high level of resistance to 5-nitroimidazole were compared with three strains previously studied by Southern blotting of their DNA. Whether plasmid-borne or chromosomally determined, all genetic determinants that are resistant to 5-nitroimidazole belong to two hybridization groups.
G, Reysset, A, Haggoud, M, Sebald
openaire   +2 more sources

Radiosensitization by Metal Complexes of 4(5)-nitroimidazole

International Journal of Radiation Biology, 1990
Four closely-related cis-platinum (Pt) complexes of 4(5)-nitroimidazole have been examined with respect to properties of radiobiological interest, to test the hypothesis that targeting a nitroimidazole (NO2Im) to DNA could enhance its radiosensitizing ability: I [PtCl2(5-NO2Im)2]; II [PtCl2(4-NO2Im)2]; III [PtCl2(NH3)(5-NO2Im)]; IV [PtCl2(NH3)(4-NO2Im)]
K A, Skov, N P, Farrell
openaire   +2 more sources

Studies on the disposition of a 5-nitroimidazole in laboratory animals

European Journal of Drug Metabolism and Pharmacokinetics, 1987
The disposition and metabolism of a 5-nitroimidazole compound (SC 28538) was investigated in the rat, beagle dog and rhesus monkey. The absorption of [14C]-SC 28538 was rapid and essentially complete after oral dosage in male animals, and also after intravaginal dosage in the female rat. Peak plasma levels of radioactivity occurred within 2 h of dosage.
A, Barrow, S R, Burford, T J, Forrest, A J, Hawkins, D A, Rose, P M, Stevens, C W, Vose, C M, Walls   +7 more
openaire   +2 more sources

Mammalian spot test with moxnidazole, a 5-nitroimidazole

Experientia, 1978
Moxnidazole [3-(5-nitrol-1-methyl-2-imidazolyl)-methyleneamino-5-morpholinomethyl-2-oxazolidinone, HCl], known to be mutagenic in microbial tests and Drosophila, induced genetic alterations in somatic cells of mice. Ethyl methanesulfonate (EMS) served as positive control.
openaire   +2 more sources

Effects of niridazole and 5-nitroimidazoles on heart mitochondrial respiration

Biochemical Pharmacology, 1982
2.3 micromoles/mg protein of MFNI induced a 60% decrease in the heart mitochondrial ADP-stimulated oxygen uptake using glutamate-malate as substrate. The same amount of niridazole, ipronidazole, DA 3851 and ornidazole led to falls of less than 20% in the oxygen uptake, whilst metronidazole was ineffective. State 3 and state 3 mu (uncoupled) respiration
G, Aicardi, G, Solaini
openaire   +2 more sources