Results 61 to 70 of about 9,970,544 (261)

Putting the Pedal to the Metal Through Education

, 2000
The 500 Festival Foundation generates funds to support 500 Festival youth and educational programs such as the 500 Festival & Indianapolis 500 Education Program. Indiana’s fourth graders learn about the Festival’s and the Indianapolis 500’s importance in
500 Festival
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PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

It Takes Community Spirit!

, 2000
The 500 Festival Volunteer Program continues to demonstrate the importance of community and teamwork to the 500 Festival’s success. Year after year they contribute about 50,000 hours. Nearly 7,000 volunteers have more than 100 areas of opportunity to see
500 Festival
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Development and Verification of Small Mammal Life Support System for Microgravity Environment in Space

Aerospace
With the development of the deep space exploration missions, performing in-orbit experiments with small mammals to investigate the effects of microgravity and cosmic radiation on mammalian life becomes increasingly important.
Ru Yuan, Yixi Wang, Wenting Gao, Xiaojun Yan, Jianzhong Gu, Weibo Zheng, Fangwu Liu, Tianda Li, Tao Zhang   +8 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Festival Royalty

, 1959
Since 1959, more than 1,700 young women from Indiana have experienced the honor of being selected to participate in the 500 Festival Princess Program.
500 Festival
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TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

And ... It All Began with a Theme

, 1958
Since its inception, the 500 Festival has annually selected a community volunteer to serve as a Chairman of the Board. Another highly regarded position is the Parade Grand Marshal. Parade goers anxiously await the announcement each year.
500 Festival
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Defense manifestations of enzymatic and non-enzymatic antioxidants in Ricinus communis L. exposed to lead in hydroponics

The EuroBiotech Journal, 2019
Lead (Pb) is a major inorganic pollutant with no biological significance and has been a global concern. Phytotoxicity of lead induces toxic effects by generating reactive oxygen species (ROS), which inhibits most of the cellular processes in plants ...
Kiran Boda Ravi, Prasad M.N.V.
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source