Results 31 to 40 of about 243,130 (240)

Digital economy policies and corporate technology spillovers: A data-driven perspective

International Review of Economics & Finance
Efficient data aggregation and allocation are crucial for driving scientific and technological innovation, resource allocation efficiency, and technology spillovers.
Zhanyu Zhang, Jingdong Cao, Ruihao Ma, Yiqiang Feng   +3 more
doaj   +1 more source

MicroRNA-590-3p promotes cell proliferation and invasion by targeting inositol polyphosphate 4-phosphatase type II in human prostate cancer cells

Tumor Biology, 2017
Inositol polyphosphate 4-phosphatase type II emerges as a tumor suppressor in prostate cancer, and its loss of expression is associated with poor prognosis for prostate cancer.
Haiwen Chen, Qidong Luo, Hongliang Li
doaj   +1 more source

MicroRNA-590-5p antagonizes the inhibitory effect of high glucose on osteoblast differentiation by suppressing Smad7 in MC3T3-E1 cells

Journal of International Medical Research, 2019
Objective MicroRNA-590-5p (miR-590-5p) has been reported to stimulate osteoblast differentiation; however, its effect in diabetic osteoporosis remains unknown.
Yinan Chen, Changhui Sun, Jiong Lu, Ling Zou, Minwei Hu, Zeyu Yang, Yaozeng Xu   +6 more
doaj   +1 more source

Systematic Comparison of Vectorization Methods in Classification Context

Applied Sciences, 2022
Natural language processing has been the subject of numerous studies in the last decade. These have focused on the various stages of text processing, from text preparation to vectorization to final text comprehension. The goal of vector space modeling is
Urszula Krzeszewska, Aneta Poniszewska-Marańda, Joanna Ochelska-Mierzejewska   +2 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

miR-590-3p and Its Downstream Target Genes in HCC Cell Lines

Analytical Cellular Pathology, 2019
miRNAs are small non-coding RNA sequences of 18-25 nucleotides. They can regulate different cellular pathways by acting on tumor suppressors, oncogenes, or both.
Mennatallah Elfar, Asma Amleh
doaj   +1 more source

Inhibition of the aberrant A1CF-FAM224A-miR-590-3p-ZNF143 positive feedback loop attenuated malignant biological behaviors of glioma cells

Journal of Experimental & Clinical Cancer Research, 2019
Background Glioma is the most common and lethal type of malignant brain tumor. Accumulating evidence has highlighted that RNA binding protein APOBEC1 complementation factor (A1CF) is involved in various cellular processes by modulating RNA expression ...
Yichen Song, Lianqi Shao, Yixue Xue, Xuelei Ruan, Xiaobai Liu, Chunqing Yang, Jian Zheng, Shuyuan Shen, Jiajia Chen, Zhen Li, Yunhui Liu   +10 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Case Studies with the Contiki-NG Simulator to Design Strategies for Sensors’ Communication Optimization in an IoT-Fog Ecosystem

Sensors, 2023
With the development of mobile communications and the Internet of Things (IoT), IoT devices have increased, allowing their application in numerous areas of Industry 4.0.
Antonio Marcos Almeida Ferreira, Leonildo José de Melo de Azevedo, Júlio Cezar Estrella, Alexandre Cláudio Botazzo Delbem   +3 more
doaj   +1 more source