Results 41 to 50 of about 1,334,870 (300)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Long tailed trions in monolayer MoS2: Temperature dependent asymmetry and resulting red-shift of trion photoluminescence spectra

Scientific Reports, 2017
Monolayer molybdenum disulfide (MoS2) has emerged as a model system for studying many-body physics because the low dimensionality reduces screening leading to tightly bound states stable at room temperature. Further, the many-body states possess a pseudo-
Jason W. Christopher, Bennett B. Goldberg, Anna K. Swan   +2 more
doaj   +1 more source

A miR-590/Acvr2a/Rad51b Axis Regulates DNA Damage Repair during mESC Proliferation

Stem Cell Reports, 2014
Embryonic stem cells (ESCs) enable rapid proliferation that also causes DNA damage. To maintain genomic stabilization during rapid proliferation, ESCs must have an efficient system to repress genotoxic stress.
Qidong Liu, Guiying Wang, Yafang Chen, Guoping Li, Dandan Yang, Jiuhong Kang   +5 more
doaj   +1 more source

Circular RNA circ_0020123 promotes non-small cell lung cancer progression by sponging miR-590-5p to regulate THBS2

Cancer Cell International, 2020
Background The incidence and death rate of non-small cell lung cancer (NSCLC) in China ranks the first among the malignant tumors. Circular RNA (circRNA) was reported to be involved in the progression of NSCLC.
Liang Wang, Lantao Zhao, Yonghong Wang
doaj   +1 more source

The Great Medical Malpractice Hoax: NPDB Data Continue to Show Medical Liability System Produces Rational Outcomes [PDF]

, 2007
Despite claims by business and medical lobbying interests and the Bush administration, there is no medical malpractice lawsuit crisis in America, according to this report by Public Citizen.
Lara Chausow, Seth Oldmixon
core  

Polarization observables in the processes $p+p\to \Theta^+ +\Sigma^+$ and $n+p\to \Theta^+ +\Lambda^0$, for any spin and parity of the $\Theta^+$-hyperon in the threshold region

, 2004
Using the symmetry properties of the strong interaction, such as the Pauli principle, the P-invariance, the conservation of the total angular momentum and isotopic invariance, we establish the spin structure of the threshold matrix elements for the ...
590, 83, Bilenky, Bohr, Diakonov, E. Tomasi-Gustafsson, Fayazuddin, Hosaka, Jaffe, M. P. Rekalo, Moskal, Pak, Rekalo, Rekalo, Stancu, Thomas, Uzikov, Zhu   +17 more
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The Gell-Mann -- Okubo mass relation among baryons from fully-dynamical mixed-action lattice QCD

, 2006
We explore the Gell-Mann--Okubo mass relation among the octet baryons using fully-dynamical, mixed-action (domain-wall on rooted-staggered) lattice QCD calculations at a lattice spacing of b ~ 0.125 fm and pion masses of m_pi ~ 290 MeV, 350 MeV, 490 MeV ...
Ademollo, Allton, Aoki, Aoki, Aubin, Aubin, Bar, Beane, Beane, Bernard, Bernard, Bernard, Bernard, Bernard, Bhattacharya, Bhattacharya, Bhattacharya, Bijnens, Blum, Bowler, Butler, Creutz, Dashen, DeGrand, DeGrand, Durr, Durr, Durr, Edwards, Edwards, Flores-Mendieta, Frink, Furman, Gell-Mann, Hasenfratz, Hasenfratz, Jenkins, Jenkins, Kostas Orginos, Leinweber, Martin J. Savage, Namekawa, Ne'eman, Okubo, Orginos, Orginos, Renner, Shamir, Silas R. Beane, Tiburzi, Walker-Loud   +50 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

ATF-3/miR-590/GOLPH3 signaling pathway regulates proliferation of breast cancer

BMC Cancer, 2018
Background Breast cancer is one of the leading causes of death in women worldwide. Fast growth is the important character of breast cancer, which makes sure the subsequent metastasize and invasion breast cancer.
Qiong Song, Qiu Chen, Qimin Wang, Longqiu Yang, Dongdong Lv, Guangli Jin, Jiaying Liu, Baolin Li, Xuejie Fei   +8 more
doaj   +1 more source