miR-590-5p Overexpression Alleviates β-Amyloid-Induced Neuron Damage via Targeting Pellino-1 [PDF]
Analytical Cellular Pathology, 2022 Alzheimer’s disease (AD) is one common degenerative disorder. However, the effects of miR-590-5p on AD and the mechanism on modulation of AD development were unclear.
Lin Shang +6 more
doaj +5 more sources
Exosomal miR-590-5p in Serum as a Biomarker for the Diagnosis and Prognosis of Gastric Cancer [PDF]
Frontiers in Molecular Biosciences, 2021 The purpose of this study is to explore the expression of miRNA-590-5p, an exosome of gastric cancer (GC), and to evaluate the suitability of miR-590-5p, an exosome with its own clinical characteristics. Serum samples from 168 gastric cancer patients and
Guo-Dian Zheng +9 more
doaj +5 more sources
Prognostic value of circ_0000043/miR-590-5p in cervical cancer and regulation of tumor progression [PDF]
Discover OncologyObjective To investigate the prognostic value of circ_0000043 in cervical cancer (CC) and its involvement in the modulation of patients’ prognostic progression.
Yue Zhu +4 more
doaj +4 more sources
miR-590-5p/Tiam1-mediated glucose metabolism promotes malignant evolution of pancreatic cancer by regulating SLC2A3 stability [PDF]
Cancer Cell International, 2023 Background T lymphoma invasion and metastasis 1 (Tiam1) is a tumor related gene that specifically activates Rho-like GTPases Rac1 and plays a critical role in the progression of various malignancies.
Ying Liu +6 more
doaj +4 more sources
miR-590-5p suppresses hepatocellular carcinoma chemoresistance by targeting YAP1 expressionResearch in context [PDF]
EBioMedicine, 2018 Background: Resistance to chemotherapeutic treatment is a common phenomenon in cancers, especially in hepatocellular carcinoma (HCC). The Hippo signaling pathway has been demonstrated to play a role in tumor initiation, development, and progression ...
Minjiang Chen +10 more
doaj +6 more sources
Circular RNA CircEPB41L2 Functions as Tumor Suppressor in Hepatocellular Carcinoma Through Sponging miR-590-5p [PDF]
Cancer Management and Research, 2021 Feng Chen,1,2 Lei He,2,3 Liman Qiu,2,3 Yang Zhou,2,3 Zhenli Li,2,3 Geng Chen,2,3 Fuli Xin,2,3 Xiuqing Dong,2,3 Haipo Xu,2,3 Gaoxiong Wang,4 Jingfeng Liu,2,3 Zhixiong Cai2,3 1College of Life Science, Fujian Agriculture and Forestry University, Fuzhou ...
Chen F +11 more
doaj +6 more sources
miR-590–5p: A double-edged sword in the oncogenesis process
Cancer Treatment and Research Communications, 2022 Accumulating evidence suggests the critical role of miR-590–5p in various aspects of cellular homeostasis, including cancer. Furthermore, we and others have recently demonstrated that miRNA-590–5p acts as an oncogene in some cancers while it acts as a ...
Tushar Singh Barwal +12 more
doaj +3 more sources
miR-590-5p Targets Skp2 to Inhibit the Growth and Invasion of Malignant Melanoma Cells. [PDF]
Dis Markers, 2022 Skp2 participates in the regulation of cell growth cycle and promotes the growth of tumor cells. It was speculated that miR-590-5p could regulate the expression of Skp2 and have therapeutic effects on malignant melanin. In this study, the expression of Skp2 was detected by qRT-PCR and Western blot (WB), and the targeted binding between miR-590-5p and ...
Tong Y, Jin L.
europepmc +3 more sources
hsa_circ_0010889 downregulation inhibits malignant glioma progression by modulating the miR-590-5p/SATB1 axis. [PDF]
Aging (Albany NY), 2023 Glioma is a general neurological tumor and circular RNAs (circRNAs) have been implicated in glioma development. However, the underlying mechanisms and circRNA biological functions responsible for the regulation of glioma progression remain unknown. In this study, we employ next-generation sequencing (NGS) to investigate altered circRNA expression in ...
Wu Z, Guan Q.
europepmc +3 more sources
miR-590-5p targets RMND5A and promotes migration in pancreatic adenocarcinoma cell lines. [PDF]
Oncol Lett, 2021 Required for meiotic nuclear division 5 homolog A (RMND5A) functions as an E3 ubiquitin ligase. To date, few studies have investigated the role of RMND5A in cancer. In the present study, the expression levels of RMND5A in multiple types of cancer were analyzed using the Gene Expression Profiling Interactive Analysis platform.
Chen S +13 more
europepmc +4 more sources