miR-590-5p suppresses hepatocellular carcinoma chemoresistance by targeting YAP1 expressionResearch in context [PDF]
EBioMedicine, 2018 Background: Resistance to chemotherapeutic treatment is a common phenomenon in cancers, especially in hepatocellular carcinoma (HCC). The Hippo signaling pathway has been demonstrated to play a role in tumor initiation, development, and progression ...
Minjiang Chen +10 more
doaj +6 more sources
Molecular CancerHepatocellular carcinoma (HCC) is a major global health concern, necessitating innovative therapeutic strategies. In this study, we investigated the functional role of circular RNA circDCUN1D4 in HCC progression and its potential therapeutic implications.
Hongyu Li +9 more
doaj +4 more sources
Peroxisome Proliferator-Activated Receptor-γ Antagonizes LOX-1-Mediated Endothelial Injury by Transcriptional Activation of miR-590-5p [PDF]
PPAR Research, 2019 Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is one of the major receptors expressed on the endothelium of arterial wall with a key role in endothelial dysfunction and the development of atherosclerosis.
Lei Xu +6 more
doaj +2 more sources
m6A reader IGF2BP2-stabilized lncRNA LHX1-DT inhibits renal cell carcinoma (RCC) cell proliferation and invasion by sponging miR-590-5p [PDF]
npj Precision OncologyN6-methyladenosine (m6A) has been established as a critical regulator in various human cancers. However, the role of m6A modification in renal cell carcinoma (RCC) and its interaction with long non-coding RNA LHX1-DT (LHX1-DT) remains unclear ...
Chunming Zhu +7 more
doaj +2 more sources
The miR-590/Acvr2a/Terf1 Axis Regulates Telomere Elongation and Pluripotency of Mouse iPSCs
Stem Cell Reports, 2018 Summary: During reprogramming, telomere re-elongation is important for pluripotency acquisition and ensures the high quality of induced pluripotent stem cells (iPSCs), but the regulatory mechanism remains largely unknown.
Jiuhong Kang, Tong Han, Wenwen Jia
exaly +3 more sources
Cell Journal, 2016 Objective: SMAD proteins are the core players of the transforming growth factor-beta (TGFβ) signaling pathway, a pathway which is involved in cell proliferation, differentiation and migration.
Meisam Jafarzadeh, Bahram M. Soltani
doaj +3 more sources
hsa_circ_0010889 downregulation inhibits malignant glioma progression by modulating the miR-590-5p/SATB1 axis. [PDF]
Aging (Albany NY), 2023 Glioma is a general neurological tumor and circular RNAs (circRNAs) have been implicated in glioma development. However, the underlying mechanisms and circRNA biological functions responsible for the regulation of glioma progression remain unknown. In this study, we employ next-generation sequencing (NGS) to investigate altered circRNA expression in ...
Wu Z, Guan Q.
europepmc +3 more sources
miR-590-5p Targets Skp2 to Inhibit the Growth and Invasion of Malignant Melanoma Cells. [PDF]
Dis Markers, 2022 Skp2 participates in the regulation of cell growth cycle and promotes the growth of tumor cells. It was speculated that miR-590-5p could regulate the expression of Skp2 and have therapeutic effects on malignant melanin. In this study, the expression of Skp2 was detected by qRT-PCR and Western blot (WB), and the targeted binding between miR-590-5p and ...
Tong Y, Jin L.
europepmc +3 more sources
miR-590-5p targets RMND5A and promotes migration in pancreatic adenocarcinoma cell lines. [PDF]
Oncol Lett, 2021 Required for meiotic nuclear division 5 homolog A (RMND5A) functions as an E3 ubiquitin ligase. To date, few studies have investigated the role of RMND5A in cancer. In the present study, the expression levels of RMND5A in multiple types of cancer were analyzed using the Gene Expression Profiling Interactive Analysis platform.
Chen S +13 more
europepmc +4 more sources
Hsa_circ_0001658 accelerates the progression of colorectal cancer through miR-590-5p/METTL3 regulatory axis. [PDF]
World J Gastrointest Oncol, 2023 As reported, multiple circular RNAs (circRNAs) interfere with colorectal cancer (CRC) progression. Here, circRNA_0001658 (circ_0001658) is focused on studying how it works in CRC.Clarify the expression pattern, biological function, and underlying mechanism of circ_0001658 of CRC tumorigenesis.In CRC-related chip data retrieved using the database named ...
Lu Y, Wang XM, Li ZS, Wu AJ, Cheng WX.
europepmc +3 more sources