Results 11 to 20 of about 4,830 (194)

miR-590-5p suppresses hepatocellular carcinoma chemoresistance by targeting YAP1 expressionResearch in context [PDF]

EBioMedicine, 2018
Background: Resistance to chemotherapeutic treatment is a common phenomenon in cancers, especially in hepatocellular carcinoma (HCC). The Hippo signaling pathway has been demonstrated to play a role in tumor initiation, development, and progression ...
Minjiang Chen, Liming Wu, Jianfei Tu, Zhongwei Zhao, Xiaoxi Fan, Jianting Mao, Qiaoyou Weng, Xulu Wu, Li Huang, Min Xu, Jiansong Ji   +10 more
doaj   +7 more sources

miR-590–5p: A double-edged sword in the oncogenesis process

Cancer Treatment and Research Communications, 2022
Accumulating evidence suggests the critical role of miR-590–5p in various aspects of cellular homeostasis, including cancer. Furthermore, we and others have recently demonstrated that miRNA-590–5p acts as an oncogene in some cancers while it acts as a ...
Tushar Singh Barwal, Neha Singh, Uttam Sharma, Sonali Bazala, Medha Rani, Alisha Behera, Ram Kumar Kumawat, Pawan Kumar, Vivek Uttam, Akanksha Khandelwal, Jyoti Barwal, Manju Jain, Aklank Jain   +12 more
doaj   +4 more sources

Prognostic value of circ_0000043/miR-590-5p in cervical cancer and regulation of tumor progression [PDF]

Discover Oncology
Objective To investigate the prognostic value of circ_0000043 in cervical cancer (CC) and its involvement in the modulation of patients’ prognostic progression.
Yue Zhu, Xi Shi, Shanshan Zhang, Hongyin Cui, Baohua Wu   +4 more
doaj   +4 more sources

Hsa-miR-590-5p Interaction with SMAD3 Transcript Supports Its Regulatory Effect on The TGFβ Signaling Pathway

Cell Journal, 2016
Objective: SMAD proteins are the core players of the transforming growth factor-beta (TGFβ) signaling pathway, a pathway which is involved in cell proliferation, differentiation and migration.
Meisam Jafarzadeh, Bahram M. Soltani
doaj   +4 more sources

miR-590-5p targets RMND5A and promotes migration in pancreatic adenocarcinoma cell lines. [PDF]

Oncol Lett, 2021
Required for meiotic nuclear division 5 homolog A (RMND5A) functions as an E3 ubiquitin ligase. To date, few studies have investigated the role of RMND5A in cancer. In the present study, the expression levels of RMND5A in multiple types of cancer were analyzed using the Gene Expression Profiling Interactive Analysis platform.
Chen S, Chen Y, Wen Y, Cai W, Zhu P, Yuan W, Li Y, Fan X, Wan Y, Li F, Zhuang J, Jiang Z, Wu X, Wang Y.   +13 more
europepmc   +5 more sources

miR-590-5p Targets Skp2 to Inhibit the Growth and Invasion of Malignant Melanoma Cells. [PDF]

Dis Markers, 2022
Skp2 participates in the regulation of cell growth cycle and promotes the growth of tumor cells. It was speculated that miR-590-5p could regulate the expression of Skp2 and have therapeutic effects on malignant melanin. In this study, the expression of Skp2 was detected by qRT-PCR and Western blot (WB), and the targeted binding between miR-590-5p and ...
Tong Y, Jin L.
europepmc   +5 more sources

miR‑590‑5p inhibits tumor growth in malignant melanoma by suppressing YAP1 expression. [PDF]

Oncol Rep, 2018
The microRNAs (miRNAs/miRs) involved in the carcinogenesis and progression of malignant melanoma (MM) remain unclear. In the present study, miR‑590‑5p was identified to be upregulated in MM cells compared with human melanocytes using a reverse transcription‑quantitative polymerase chain reaction to screen established oncogenic and tumor suppressor ...
Mou K, Ding M, Han D, Zhou Y, Mu X, Liu W, Wang L.   +6 more
europepmc   +6 more sources

hsa_circ_0010889 downregulation inhibits malignant glioma progression by modulating the miR-590-5p/SATB1 axis. [PDF]

Aging (Albany NY), 2023
Glioma is a general neurological tumor and circular RNAs (circRNAs) have been implicated in glioma development. However, the underlying mechanisms and circRNA biological functions responsible for the regulation of glioma progression remain unknown. In this study, we employ next-generation sequencing (NGS) to investigate altered circRNA expression in ...
Wu Z, Guan Q.
europepmc   +5 more sources

MiR-590-5p Inhibits Oxidized- LDL Induced Angiogenesis by Targeting LOX-1. [PDF]

Sci Rep, 2016
AbstractOxidized low-density lipoprotein (ox-LDL) is, at least in part, responsible for angiogenesis in atherosclerotic regions. This effect of ox-LDL has been shown to be mediated through a specific receptor LOX-1. Here we describe the effect of miR-590-5p on ox-LDL-mediated angiogenesis in in vitro and in vivo settings.
Dai Y, Zhang Z, Cao Y, Mehta JL, Li J.
europepmc   +5 more sources

miR-590-5p may regulate colorectal cancer cell viability and migration by targeting PDCD4. [PDF]

Exp Ther Med, 2020
Recent studies have revealed that microRNAs (miRs) are involved in the pathogenesis of colorectal cancer (CRC); however, the roles of miR-590-5p in CRC are not completely understood. Therefore, the present study investigated the expression of miR-590-5p and programmed cell death 4 (PDCD4) in CRC tissues and healthy adjacent tissues via reverse ...
Guo T, Wang J, Cheng G, Huang H.
europepmc   +5 more sources