Results 21 to 30 of about 4,260 (145)

miR-379-5p promotes ovarian granulosa cell apoptosis in primary ovarian insufficiency by targeting KNDC1 and PEG10 [PDF]

Frontiers in Genetics
BackgroundPrimary ovarian insufficiency (POI) is a heterogeneous disorder characterized by premature decline in ovarian function in women of reproductive age, yet its molecular mechanisms remain incompletely elucidated.
Jie Luo, Jie Luo, Fan Zhang, Yurong Feng, Fang You, Daobin Yang, Zengguang Wu, Li Zeng, Li Zeng   +8 more
doaj   +2 more sources

miR-590-5p may regulate colorectal cancer cell viability and migration by targeting PDCD4. [PDF]

Exp Ther Med, 2020
Recent studies have revealed that microRNAs (miRs) are involved in the pathogenesis of colorectal cancer (CRC); however, the roles of miR-590-5p in CRC are not completely understood. Therefore, the present study investigated the expression of miR-590-5p and programmed cell death 4 (PDCD4) in CRC tissues and healthy adjacent tissues via reverse ...
Guo T, Wang J, Cheng G, Huang H.
europepmc   +4 more sources

miR‑590‑5p inhibits tumor growth in malignant melanoma by suppressing YAP1 expression. [PDF]

Oncol Rep, 2018
The microRNAs (miRNAs/miRs) involved in the carcinogenesis and progression of malignant melanoma (MM) remain unclear. In the present study, miR‑590‑5p was identified to be upregulated in MM cells compared with human melanocytes using a reverse transcription‑quantitative polymerase chain reaction to screen established oncogenic and tumor suppressor ...
Mou K, Ding M, Han D, Zhou Y, Mu X, Liu W, Wang L.   +6 more
europepmc   +4 more sources

Coxsackievirus B infection induces the extracellular release of miR-590-5p, a proviral microRNA. [PDF]

Virology, 2019
Coxsackievirus B is a significant human pathogen and is a leading cause of myocarditis. We and others have observed that certain enteroviruses including coxsackievirus B cause infected cells to shed extracellular vesicles containing infectious virus. Recent reports have shown that vesicle-bound virus can infect more efficiently than free virus.
Germano JF, Sawaged S, Saadaeijahromi H, Andres AM, Feuer R, Gottlieb RA, Sin J.   +6 more
europepmc   +3 more sources

CFIm25-regulated lncRNA acv3UTR promotes gastric tumorigenesis via miR-590-5p/YAP1 axis. [PDF]

Oncogene, 2020
AbstractAccumulating evidences indicate that 3ʹUTR of the coding gene can act as crucial regulators in gastric cancer (GC). However, the detailed mechanisms and responsive targets are not well established. Here, we found thatacvr1bgene 3ʹUTR (acv3UTR) was elevated in GC tissue, the expression of which was significantly correlated with advanced pTNM ...
Liu K, Wang BJ, Han W, Chi CH, Gu C, Wang Y, Fu X, Huang W, Liu Z, Song X.   +9 more
europepmc   +4 more sources

Erratum: [Corrigendum] miR‑590‑5p may regulate colorectal cancer cell viability and migration by targeting PDCD4. [PDF]

Exp Ther Med
Guo T, Wang J, Cheng G, Huang H.
europepmc   +2 more sources

MiR-590-5p Inhibits Oxidized- LDL Induced Angiogenesis by Targeting LOX-1. [PDF]

Sci Rep, 2016
AbstractOxidized low-density lipoprotein (ox-LDL) is, at least in part, responsible for angiogenesis in atherosclerotic regions. This effect of ox-LDL has been shown to be mediated through a specific receptor LOX-1. Here we describe the effect of miR-590-5p on ox-LDL-mediated angiogenesis in in vitro and in vivo settings.
Dai Y, Zhang Z, Cao Y, Mehta JL, Li J.
europepmc   +4 more sources

Evaluation of BMP2/miRNA co-expression systems for potent therapeutic efficacy in bone-tissue regeneration [PDF]

European Cells & Materials, 2021
Reconstruction of bone defects and compensation of deficient repair mechanisms represent important goals within the field of regenerative medicine and require novel safe strategies for translation into the clinic.
TK Brenner, K Posa-Markaryan, D Hercher, S Sperger, P Heimel, C Keibl, S Nürnberger, J Grillari, H Redl, A Hacobian   +9 more
doaj   +1 more source

The lncRNA PVT1/miR-590-5p/FSTL1 axis modulates the proliferation and migration of airway smooth muscle cells in asthma

Autoimmunity, 2021
Objective Asthma is a prevalent chronic inflammatory airway disease that is characterised by airway remodelling and airway hyperresponsiveness. Abnormal proliferation and migration of airway smooth muscle cells (ASMCs) contribute to airway remodelling in
Wen-Lan Wang, Xiao-Ming Luo, Qin Zhang, Hai-Qiao Zhu, Guo-Qing Chen, Qin Zhou   +5 more
doaj   +1 more source

Knockdown of lncRNA NUTM2A-AS1 inhibits lung adenocarcinoma cell viability by regulating the miR-590-5p/METTL3 axis.

Oncol Lett, 2021
Lung adenocarcinoma (LUAD) is the leading cause of cancer-related mortality worldwide. Long non-coding RNA (lncRNA) NUT family member 2A antisense RNA 1 (NUTM2A-AS1) is dysregulated in LUAD; however, its role in this disease remains unclear. The present study aimed to identify the underlying molecular mechanism of the effect of lncRNA NUTM2A-AS1 in ...
Wang J, Zha J, Wang X.
europepmc   +4 more sources