Molecular CancerHepatocellular carcinoma (HCC) is a major global health concern, necessitating innovative therapeutic strategies. In this study, we investigated the functional role of circular RNA circDCUN1D4 in HCC progression and its potential therapeutic implications.
Hongyu Li +9 more
doaj +2 more sources
Common miR-590 Variant rs6971711 Present Only in African Americans Reduces miR-590 Biogenesis.
PLoS ONE, 2016 MicroRNAs (miRNAs) are recognized as important regulators of cardiac development, hypertrophy and fibrosis. Recent studies have demonstrated that genetic variations which cause alterations in miRNA:target interactions can lead to disease. We hypothesized
Xiaoping Lin +15 more
doaj +2 more sources
lncRNA-ATB functions as a competing endogenous RNA to promote YAP1 by sponging miR-590-5p in malignant melanoma. [PDF]
Int J Oncol, 2018 The critical long non‑coding RNAs (lncRNAs) involved in the carcinogenesis and progression of malignant melanoma (MM) have not been fully investigated. In the present study, it was identified that lncRNA activated by transforming growth factor‑β (lncRNA‑ATB) was upregulated in MM tissues and cells compared with benign nevus cells and human melanocytes,
Mou K +6 more
europepmc +4 more sources
Erratum: [Corrigendum] miR‑590‑5p may regulate colorectal cancer cell viability and migration by targeting PDCD4. [PDF]
Exp Ther MedGuo T, Wang J, Cheng G, Huang H.
europepmc +2 more sources
The Effect of miR-34a-5p and miR-145-5p Ectopic Expression on Cell Proliferation and Target Gene Expression in the MDA-MB-231 Cell Line [PDF]
, 2021 Aim:It was aimed to investigate the effect of miR-34a-5p and miR-145-5p on breast cancer cell line MDA-MB-231 and to determine the expression of target genes of these microRNAs (miRNAs).Materials and Methods:Firstly, literature search and in silico ...
Emre ÖZGÜR +5 more
core +1 more source
Evaluation of BMP2/miRNA co-expression systems for potent therapeutic efficacy in bone-tissue regeneration [PDF]
European Cells & Materials, 2021 Reconstruction of bone defects and compensation of deficient repair mechanisms represent important goals within the field of regenerative medicine and require novel safe strategies for translation into the clinic.
TK Brenner +9 more
doaj +1 more source
Potential Value of Circular RNA circTBC1D4 in Gastrointestinal Stromal Tumors
Journal of Immunology Research, 2022 Aims. To explore the expression of circular RNA (circRNA) in gastrointestinal stromal tumors. Background. Gastrointestinal stromal tumors (GIST) are mainly distributed in the stomach and small intestine.
null Chunyan-Zou +7 more
doaj +1 more source
Non-coding RNA Activated by DNA Damage: Review of Its Roles in the Carcinogenesis
Frontiers in Cell and Developmental Biology, 2021 Long intergenic non-coding RNA 00657 (LINC00657) or “non-coding RNA activated by DNA damage” (NORAD) is an extremely conserved and copious long non-coding RNA (lncRNA). This transcript has pivotal role in the preservation of genome integrity.
Soudeh Ghafouri-Fard +5 more
doaj +1 more source
Scientific Reports, 2022 Early diagnosis of breast cancer (BC), as the most common cancer among women, increases the survival rate and effectiveness of treatment. MicroRNAs (miRNAs) control various cell behaviors, and their dysregulation is widely involved in pathophysiological ...
Zahra Sharifi +2 more
doaj +1 more source
Signature of circulating microRNAs as potential biomarkers in vulnerable coronary artery disease. [PDF]
PLoS ONE, 2013 AIMS: MicroRNAs (miRNAs) play important roles in the pathogenesis of cardiovascular diseases. Circulating miRNAs were recently identified as biomarkers for various physiological and pathological conditions.
Jingyi Ren +8 more
doaj +1 more source