Common miR-590 Variant rs6971711 Present Only in African Americans Reduces miR-590 Biogenesis.
PLoS ONE, 2016 MicroRNAs (miRNAs) are recognized as important regulators of cardiac development, hypertrophy and fibrosis. Recent studies have demonstrated that genetic variations which cause alterations in miRNA:target interactions can lead to disease. We hypothesized
Xiaoping Lin +15 more
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hsa_circ_0010889 downregulation inhibits malignant glioma progression by modulating the miR-590-5p/SATB1 axis. [PDF]
Aging (Albany NY), 2023 Glioma is a general neurological tumor and circular RNAs (circRNAs) have been implicated in glioma development. However, the underlying mechanisms and circRNA biological functions responsible for the regulation of glioma progression remain unknown. In this study, we employ next-generation sequencing (NGS) to investigate altered circRNA expression in ...
Wu Z, Guan Q.
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miR-590-5p Targets Skp2 to Inhibit the Growth and Invasion of Malignant Melanoma Cells. [PDF]
Dis Markers, 2022 Skp2 participates in the regulation of cell growth cycle and promotes the growth of tumor cells. It was speculated that miR-590-5p could regulate the expression of Skp2 and have therapeutic effects on malignant melanin. In this study, the expression of Skp2 was detected by qRT-PCR and Western blot (WB), and the targeted binding between miR-590-5p and ...
Tong Y, Jin L.
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miR-590-5p targets RMND5A and promotes migration in pancreatic adenocarcinoma cell lines. [PDF]
Oncol Lett, 2021 Required for meiotic nuclear division 5 homolog A (RMND5A) functions as an E3 ubiquitin ligase. To date, few studies have investigated the role of RMND5A in cancer. In the present study, the expression levels of RMND5A in multiple types of cancer were analyzed using the Gene Expression Profiling Interactive Analysis platform.
Chen S +13 more
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Hsa_circ_0001658 accelerates the progression of colorectal cancer through miR-590-5p/METTL3 regulatory axis. [PDF]
World J Gastrointest Oncol, 2023 As reported, multiple circular RNAs (circRNAs) interfere with colorectal cancer (CRC) progression. Here, circRNA_0001658 (circ_0001658) is focused on studying how it works in CRC.Clarify the expression pattern, biological function, and underlying mechanism of circ_0001658 of CRC tumorigenesis.In CRC-related chip data retrieved using the database named ...
Lu Y, Wang XM, Li ZS, Wu AJ, Cheng WX.
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miR-379-5p promotes ovarian granulosa cell apoptosis in primary ovarian insufficiency by targeting KNDC1 and PEG10 [PDF]
Frontiers in GeneticsBackgroundPrimary ovarian insufficiency (POI) is a heterogeneous disorder characterized by premature decline in ovarian function in women of reproductive age, yet its molecular mechanisms remain incompletely elucidated.
Jie Luo +8 more
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miR-590-5p may regulate colorectal cancer cell viability and migration by targeting PDCD4. [PDF]
Exp Ther Med, 2020 Recent studies have revealed that microRNAs (miRs) are involved in the pathogenesis of colorectal cancer (CRC); however, the roles of miR-590-5p in CRC are not completely understood. Therefore, the present study investigated the expression of miR-590-5p and programmed cell death 4 (PDCD4) in CRC tissues and healthy adjacent tissues via reverse ...
Guo T, Wang J, Cheng G, Huang H.
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miR‑590‑5p inhibits tumor growth in malignant melanoma by suppressing YAP1 expression. [PDF]
Oncol Rep, 2018 The microRNAs (miRNAs/miRs) involved in the carcinogenesis and progression of malignant melanoma (MM) remain unclear. In the present study, miR‑590‑5p was identified to be upregulated in MM cells compared with human melanocytes using a reverse transcription‑quantitative polymerase chain reaction to screen established oncogenic and tumor suppressor ...
Mou K +6 more
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Coxsackievirus B infection induces the extracellular release of miR-590-5p, a proviral microRNA. [PDF]
Virology, 2019 Coxsackievirus B is a significant human pathogen and is a leading cause of myocarditis. We and others have observed that certain enteroviruses including coxsackievirus B cause infected cells to shed extracellular vesicles containing infectious virus. Recent reports have shown that vesicle-bound virus can infect more efficiently than free virus.
Germano JF +6 more
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CFIm25-regulated lncRNA acv3UTR promotes gastric tumorigenesis via miR-590-5p/YAP1 axis. [PDF]
Oncogene, 2020 AbstractAccumulating evidences indicate that 3ʹUTR of the coding gene can act as crucial regulators in gastric cancer (GC). However, the detailed mechanisms and responsive targets are not well established. Here, we found thatacvr1bgene 3ʹUTR (acv3UTR) was elevated in GC tissue, the expression of which was significantly correlated with advanced pTNM ...
Liu K +9 more
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