Results 11 to 20 of about 290,887 (206)

Exosomal miR-590-5p in Serum as a Biomarker for the Diagnosis and Prognosis of Gastric Cancer

open access: yesFrontiers in Molecular Biosciences, 2021
The purpose of this study is to explore the expression of miRNA-590-5p, an exosome of gastric cancer (GC), and to evaluate the suitability of miR-590-5p, an exosome with its own clinical characteristics. Serum samples from 168 gastric cancer patients and
Can Hu, Xu Zhi-Yuan, Hu Can
exaly   +3 more sources

Common miR-590 Variant rs6971711 Present Only in African Americans Reduces miR-590 Biogenesis.

open access: yesPLoS ONE, 2016
MicroRNAs (miRNAs) are recognized as important regulators of cardiac development, hypertrophy and fibrosis. Recent studies have demonstrated that genetic variations which cause alterations in miRNA:target interactions can lead to disease. We hypothesized
Xiaoping Lin   +15 more
doaj   +2 more sources

Exosomal miR-590-3p derived from cancer-associated fibroblasts confers radioresistance in colorectal cancer

open access: yesMolecular Therapy - Nucleic Acids, 2021
Radiotherapeutic resistance is a major obstacle for the effective treatment of colorectal cancer (CRC). MicroRNAs (miRNAs) play a critical role in chemoresistance and radioresistance.
Qinglan Zhang   +2 more
exaly   +3 more sources

MicroRNA-590-5p antagonizes the inhibitory effect of high glucose on osteoblast differentiation by suppressing Smad7 in MC3T3-E1 cells

open access: yesJournal of International Medical Research, 2019
Objective MicroRNA-590-5p (miR-590-5p) has been reported to stimulate osteoblast differentiation; however, its effect in diabetic osteoporosis remains unknown.
Yinan Chen, Zeyu Yang, Yaozeng Xu
exaly   +2 more sources

miR-590-5p mediates mitochondrial respiration, proliferation, and apoptosis in thyroid carcinoma cells via fibroblast growth factor receptor substrate 2 [PDF]

open access: yesArchives of Endocrinology and Metabolism
Objective: Thyroid carcinoma (TC) is the most common cancer of the endocrine system. Dysregulation of microRNA-590-5p (miR-590-5p) has been associated with various malignancies. Targeting mitochondrial respiration is beneficial in treating TC. This study
Penghui Wang   +5 more
doaj   +2 more sources

MiR-590-3p suppresses hepatocellular carcinoma growth by targeting TEAD1

open access: yesTumor Biology, 2017
MicroRNA signature is altered in different disease states including cancer, and some microRNAs act as oncogenes or tumor suppressors. MiR-590-3p has been shown to be involved in human cancer progression.
Xin Ge, Liansheng Gong
doaj   +2 more sources

A Conversation with 590 Nascent Entrepreneurs [PDF]

open access: yesSSRN Electronic Journal, 2007
This paper summarizes interviews from 1998 with 590 individuals trying to create a business centered around five questions: "Who are you?," "What are you trying to accomplish?," "What have you and others put into the business?," "What have you accomplished?," "What remains to be done?" There is a great deal of heterogeneity across these Nascent ...
Jeffrey R. Campbell   +1 more
openaire   +2 more sources

miR-590–5p: A double-edged sword in the oncogenesis process

open access: yesCancer Treatment and Research Communications, 2022
Accumulating evidence suggests the critical role of miR-590–5p in various aspects of cellular homeostasis, including cancer. Furthermore, we and others have recently demonstrated that miRNA-590–5p acts as an oncogene in some cancers while it acts as a ...
Tushar Singh Barwal   +12 more
doaj   +1 more source

MicroRNA-590 Inhibits Lipoprotein Lipase Expression and Prevents Atherosclerosis in apoE Knockout Mice. [PDF]

open access: yesPLoS ONE, 2015
Recent studies have suggested that miR-590 may play critical roles in cardiovascular disease. This study was designed to determine the effects of miR-590 on lipoprotein lipase (LPL) expression and development of atherosclerosis in apolipoprotein E ...
Ping-Ping He   +19 more
doaj   +1 more source

miR-590-5p Overexpression Alleviates β-Amyloid-Induced Neuron Damage via Targeting Pellino-1

open access: yesAnalytical Cellular Pathology, 2022
Alzheimer’s disease (AD) is one common degenerative disorder. However, the effects of miR-590-5p on AD and the mechanism on modulation of AD development were unclear.
Lin Shang   +6 more
doaj   +1 more source

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