Results 1 to 10 of about 15,615 (185)
The c-Abl/p73 pathway induces neurodegeneration in a Parkinson's disease model
IBRO Neuroscience Reports, 2022 Parkinson's disease is the second most common neurodegenerative disorder. Although it is clear that dopaminergic neurons degenerate, the underlying molecular mechanisms are still unknown, and thus, successful treatment is still elusive. One pro-apoptotic
Tamara Marín +7 more
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The pre-teatment effect of voluntary exercise by GDNF on lesion injectioned by 6- hydroxydopamine in brain stem of male rats Abstract [PDF]
فیزیولوژی ورزش و فعالیت بدنی, 2014 Background&Purpose: The purpose of this research was to investigate the protective effect of voluntary exercise by GDNF on lesion induced by 6-hydroxydopamine in brainstem of male rats.
راضیه محمدی +3 more
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Dose-Dependent Effect of Flouxetine on 6-OHDA-Induced Catalepsy in Male Rats: A Possible Involvement of 5-HT1A Receptors [PDF]
Advanced Pharmaceutical Bulletin, 2013 Purpose: Progressive loss of dopaminergic neurons of the substantia nigra pars compacta (SNc) in Parkinson’s disease (PD) leads to impairment of motor skills. Several evidences show that the role of serotonergic system in regulation of normal movement is
Safar Farajnia +2 more
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Molecules, 2022 Parkinson’s disease (PD) is the second most common progressive neurodegenerative disease, after Alzheimer’s disease. In our previous study, we found that amber—a fossilized plant resin—can protect cells from apoptosis by decreasing the generation of ...
Yuening Luo +5 more
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PLoS ONE, 2011 BackgroundIn addition to their original applications to lowering cholesterol, statins display multiple neuroprotective effects. N-methyl-D-aspartate (NMDA) receptors interact closely with the dopaminergic system and are strongly implicated in therapeutic
Junqiang Yan +12 more
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The oxidation of 6-hydroxydopamine
Journal of Pharmacy and Pharmacology, 1973 AbstractThe oxidation of 6-hydroxydopamine (I) with molecular oxygen or potassium ferricyanide in aqueous solution has been shown to lead mainly to the formation of the uncyclized quinone 2-(β-aminoethyl)-5-hydroxy-p-benzoquinone (VII). However this quinone cyclized slowly, presumably to norepinochrome (i.e.
W S, Powell, R A, Heacock
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Neural Regeneration Research, 2018 Rotenone and 6-hydroxydopamine are two drugs commonly used to generate Parkinson’s disease animal models. They not only achieve degenerative changes of dopaminergic neurons in the substantia nigra, but also satisfy the requirements for iron deposition ...
Lan-Xiang Liu +9 more
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Protective effect of tetrahydroxystilbene glucoside on 6-OHDA-induced apoptosis in PC12 cells through the ROS-NO pathway. [PDF]
PLoS ONE, 2011 Oxidative stress plays an important role in the pathogenesis of neurodegenerative diseases, such as Parkinson's disease. The molecule, 2,3,5,4'-tetrahydr- oxystilbene-2-O-β-D-glucoside (TSG), is a potent antioxidant derived from the Chinese herb ...
Lizhen Tao +9 more
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Neural Plasticity, 2004 To investigate the mechanisms underlying motor hyperactivity, we performed intracisternal injection of 6-hydroxydopamine or endocrine disruptors in rats on postnatal day 5. 6-Hydroxydopamine (100 μg, 488 nmol) caused a significant increase in spontaneous
Yoshinori Masuo +3 more
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One-Electron Reduction of 6-Hydroxydopamine Quinone is Essential in 6-Hydroxydopamine Neurotoxicity
Neurotoxicity Research, 2013 6-Hydroxydamine has widely been used as neurotoxin in preclinical studies related on the neurodegenerative process of dopaminergic neurons in Parkinson's disease based on its ability to be neurotoxic as a consequence of free radical formation during its auto-oxidation to topaminequinone.
Villa, Monica +7 more
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