Results 1 to 10 of about 14,948 (182)
Ghrelin alleviates 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells [PDF]
Neural Regeneration Research, 2022 Ghrelin is a neuropeptide that has various physiological functions and has been demonstrated to be neuroprotective in a number of neurological disease models. However, the underlying mechanisms of ghrelin in Parkinson’s disease remain largely unexplored.
Xin He +6 more
doaj +2 more sources
The c-Abl/p73 pathway induces neurodegeneration in a Parkinson's disease model
IBRO Neuroscience Reports, 2022 Parkinson's disease is the second most common neurodegenerative disorder. Although it is clear that dopaminergic neurons degenerate, the underlying molecular mechanisms are still unknown, and thus, successful treatment is still elusive. One pro-apoptotic
Tamara Marín +7 more
doaj +1 more source
The pre-teatment effect of voluntary exercise by GDNF on lesion injectioned by 6- hydroxydopamine in brain stem of male rats Abstract [PDF]
فیزیولوژی ورزش و فعالیت بدنی, 2014 Background&Purpose: The purpose of this research was to investigate the protective effect of voluntary exercise by GDNF on lesion induced by 6-hydroxydopamine in brainstem of male rats.
راضیه محمدی +3 more
doaj +1 more source
Dose-Dependent Effect of Flouxetine on 6-OHDA-Induced Catalepsy in Male Rats: A Possible Involvement of 5-HT1A Receptors [PDF]
Advanced Pharmaceutical Bulletin, 2013 Purpose: Progressive loss of dopaminergic neurons of the substantia nigra pars compacta (SNc) in Parkinson’s disease (PD) leads to impairment of motor skills. Several evidences show that the role of serotonergic system in regulation of normal movement is
Safar Farajnia +2 more
doaj +1 more source
Molecules, 2022 Parkinson’s disease (PD) is the second most common progressive neurodegenerative disease, after Alzheimer’s disease. In our previous study, we found that amber—a fossilized plant resin—can protect cells from apoptosis by decreasing the generation of ...
Yuening Luo +5 more
doaj +1 more source
PLoS ONE, 2011 BackgroundIn addition to their original applications to lowering cholesterol, statins display multiple neuroprotective effects. N-methyl-D-aspartate (NMDA) receptors interact closely with the dopaminergic system and are strongly implicated in therapeutic
Junqiang Yan +12 more
doaj +1 more source
Protective effect of tetrahydroxystilbene glucoside on 6-OHDA-induced apoptosis in PC12 cells through the ROS-NO pathway. [PDF]
PLoS ONE, 2011 Oxidative stress plays an important role in the pathogenesis of neurodegenerative diseases, such as Parkinson's disease. The molecule, 2,3,5,4'-tetrahydr- oxystilbene-2-O-β-D-glucoside (TSG), is a potent antioxidant derived from the Chinese herb ...
Lizhen Tao +9 more
doaj +1 more source
Neural Regeneration Research, 2018 Rotenone and 6-hydroxydopamine are two drugs commonly used to generate Parkinson’s disease animal models. They not only achieve degenerative changes of dopaminergic neurons in the substantia nigra, but also satisfy the requirements for iron deposition ...
Lan-Xiang Liu +9 more
doaj +1 more source
Neural Plasticity, 2004 To investigate the mechanisms underlying motor hyperactivity, we performed intracisternal injection of 6-hydroxydopamine or endocrine disruptors in rats on postnatal day 5. 6-Hydroxydopamine (100 μg, 488 nmol) caused a significant increase in spontaneous
Yoshinori Masuo +3 more
doaj +1 more source
Translational Neurodegeneration, 2018 Background Abnormal expression of major histocompatibility complex class I (MHC-I) is increased in dopaminergic (DA) neurons in the substantia nigra (SN) in Parkinson’s disease (PD).
Ming-Shu Mo +13 more
doaj +1 more source