Results 41 to 50 of about 15,615 (185)

Pre-treatment Effects of Eriobotrya Japonica Extraction on Malondialdehyde (MDA), Brain-Derived Neurotrophic Factor (BDNF), and Superoxide Dismutase (SOD) Levels in Hippocampus of Parkinsonian Rats Induced by 6-hydroxydopamine Following 12 weeks of Volunt

مجله دانشکده پزشکی اصفهان, 2014
Background: The purpose of this study was to investigate the effects of extract of Eriobotrya japonica flower on brain-derived neurotrophic factor (BDNF), superoxide dismutase (SOD), and malondialdehyde (MDA) levels in the hippocampus of Parkinsonian ...
Zia Fallah Mohammadi, Razieh Mohammadi, Jalil Aslani   +2 more
doaj  

Evaluation of the Association Between Serum Levels of Testosterone and Prolactin With 6- Hydroxydopamine- Induced Parkinsonism in Male Rats

Basic and Clinical Neuroscience, 2021
Introduction: Parkinson’s Disease (PD) associates with changes in sex hormones; however, it remains unknown whether this is either a cause for or a result of the disease.
Roghaieh Razaghi, Hossein Piri, Hanieh Jafari, Nafiseh Rastgoo, Mohammad Ali Hosseini, Hashem Haghdoost – Yazdi   +5 more
doaj  

Natural product‐derived TRPM7 channel inhibitors in neurological injury: Mechanisms, pharmacological potential and translational challenges

British Journal of Pharmacology, EarlyView.
Disruption of intracellular ionic homeostasis is a convergent pathological feature across diverse neurological injuries and disorders, including ischaemic and haemorrhagic stroke, hypoxic–ischaemic brain injury, traumatic brain injury, epilepsy and brain tumour.
Xinyang Zhang, Hio Lam Ho, F. David Horgen, Andrea Fleig, Zhong‐Ping Feng, Hong‐Shuo Sun   +5 more
wiley   +1 more source

Prolonged intermittent theta burst stimulation restores the balance between A2AR- and A1R-mediated adenosine signaling in the 6-hydroxidopamine model of Parkinson’s disease

Neural Regeneration Research
An imbalance in adenosine-mediated signaling, particularly the increased A2AR-mediated signaling, plays a role in the pathogenesis of Parkinson’s disease. Existing therapeutic approaches fail to alter disease progression, demonstrating the need for novel
Milica Zeljkovic Jovanovic, Jelena Stanojevic, Ivana Stevanovic, Milica Ninkovic, Tihomir V. Ilic, Nadezda Nedeljkovic, Milorad Dragic   +6 more
doaj   +1 more source

Neuroanatomy education through the years: Revisiting the teaching slides used by Sir Wilfrid Edward Le Gros Clark

Journal of Anatomy, EarlyView.
This paper examines the life and legacy of British anatomist Sir Wilfrid Le Gros Clark through his neuroanatomical teaching collection at the University of Oxford. The authors catalogued 103 specimens and analyzed selected slides—including cases of multiple sclerosis, amyotrophic lateral sclerosis, tabes dorsalis, syringomyelia, and the pineal gland's ...
Shiva A. Nischal, Kush M. Kale, Katherine Tourigny, Mohammed Abuelem, Gretchen Greene, Rachel Walsh, Zoltán Molnár   +6 more
wiley   +1 more source

Dramatic differences in susceptibility to l-DOPA-induced dyskinesia between mice that are aged before or after a nigrostriatal dopamine lesion

Neurobiology of Disease, 2016
Mice with striatal 6-hydroxydopamine (6-OHDA) lesions are widely used as a model to study the effects of neurorestorative, symptomatic, or antidyskinetic treatments for Parkinson's disease (PD).
Francesco Bez, Veronica Francardo, M. Angela Cenci   +2 more
doaj   +1 more source

Mucuna pruriens as a Sustainable Functional Food: Applications From Seed to Product

Modern Agriculture, Volume 4, Issue 2, December 2026.
This review highlights Mucuna pruriens as a nutrient‐rich legume with significant nutritional, therapeutic, and agricultural value. Its protein‐rich seeds contain essential minerals and L‐DOPA, but high antinutritional compounds require effective processing before consumption.
Crossby Osei Tutu, Reuben Acheampong, Papa Toah Akonor, Bernard Kwabena Asiedu, Rexford Obeng, Anthonia Helga Andoh‐Odoom, Dora Duah‐Bisiw, Jacob Ulzen, Michael Wiafe‐Kwagyan, Nii Korley Kortei, Justice Owusu‐Bempah   +10 more
wiley   +1 more source

Nrf2-mediated protection against 6-hydroxydopamine [PDF]

Brain Research, 2007
Parkinson's disease (PD) is a neurodegenerative movement disorder characterized by cell loss in the substantia nigra resulting in striatal dopamine depletion. Although the cause of sporadic PD is unknown, oxidative stress is thought to contribute to disease pathogenesis. One mechanism by which cells defend themselves against oxidative stress is through
Rebekah J, Jakel, Jessica A, Townsend, Andrew D, Kraft, Jeffrey A, Johnson   +3 more
openaire   +2 more sources

Relationship of Serum Levels of High Density Lipoprotein (HDL) and Low Density Lipoprotein (LDL) with the Severity of Parkinson\'s Disease in an Animal Model [PDF]

Iranian South Medical Journal
Background: Parkinson's disease (PD) is the second most common neurodegenerative disease. Oxidative stress and dyslipidemia may play a key role in the pathogenesis and progression of PD.
Hashem Haghdoost Yazdi, Mohammad Sofiabadi, Hossein Khadem Haghighian, Maryam Yaghoubi   +3 more
doaj  

Effects of 6‐OHDA‐Mediated Chemical Denervation of Sympathetic Axons in Inguinal Subcutaneous White Adipose Tissue

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 10459-10474, November 2026.
ABSTRACT Aims White adipose tissue (WAT) innervation by sensory and sympathetic axons contributes to tissue functions, but the consequences of selectively disrupting sympathetic input to WAT remain incompletely defined. Materials and Methods We utilised 6‐hydroxydopamine (6‐OHDA) as a validated approach to achieve bilateral sympathetic denervation of ...
Gilian Gunsch, Gargi Mishra, Magdalena Blaszkiewicz, Erica de Sousa, Jake W. Willows, Katharine W. Alltop, Annemarie Towle, Shawn Collins, Andre Khalil, Isabel F. Snodgrass, Lara Agha, Kiran Prakash, Rashmika Maganuru, Sugasini Dhavamani, John W. Newman, Kristy L. Townsend   +15 more
wiley   +1 more source