Results 51 to 60 of about 14,948 (182)

Brain–Computer Interfaces: The Dawn of a New Era in Disease Treatment

Exploration, Volume 6, Issue 3, June 2026.
This study investigates the potential of brain–computer interface (BCI) technology in treating neuropsychiatric disorders, such as movement and communication barriers. Our review examines the history, signal paradigms, and diverse applications of BCI while also discussing ongoing research into novel materials and emerging technologies that offer ...
Yuqi Feng, Wangzheqi Zhang, Jun Chen, Huang Wu, Lei Wu, Yanhao Qiu, Xiaoming Deng, Chenglong Zhu, Yisheng Chen, Zhijie Zhao, Changli Wang, Xiaomin Zhang   +11 more
wiley   +1 more source

Low‐Concentration Dopamine Potentiates Gastric Motility Through Activation of Dopamine D5 Receptor on Enteric Cholinergic Neurons

Gut Medicine, Volume 2, Issue 2, Page 65-75, June 2026.
ABSTRACT Background Dopamine (DA) exerts complex concentration‐dependent effects on gastrointestinal motility. Although its inhibitory action through D2‐like receptors is well‐established, the mechanisms underlying its excitatory effects remain elusive.
Xiao‐Li Zhang, Tuo Ji, Yue Zhang, Cai‐Feng Zhang, Yun‐Jing Bai, Jin Song   +5 more
wiley   +1 more source

The Flavonoid Hesperetin Alleviates Behavioral Abnormality in 6-Hydroxydopamine Rat Model of Hemi-Parkinsonism

Basic and Clinical Neuroscience, 2010
Parkinson’s disease (PD) is a neuropathological and debilitating disorder involving the degeneration of mesencephalic dopaminergic neurons. Neuroprotective effect of hesperetin has already been reported, therefore, this study examined whether the ...
Tourandokht Baluchnejadmojarad, Mehrdad Roghani   +1 more
doaj   +2 more sources

Enhanced glutamate, IP3 and cAMP activity in the cerebral cortex of Unilateral 6-hydroxydopamine induced Parkinson's rats: Effect of 5-HT, GABA and bone marrow cell supplementation

Journal of Biomedical Science, 2011
Parkinson's disease is characterized by progressive cell death in the substantia nigra pars compacta, which leads to dopamine depletion in the striatum and indirectly to cortical dysfunction.
Romeo Chinthu, Malat Anitha, Kuruvilla Korah P, Paul Jes, Nandhu MS, Paulose CS   +5 more
doaj   +1 more source

Neuroprotective Effects of Herbal Ethanol Extracts from Gynostemma pentaphyllum in the 6-Hydroxydopamine-Lesioned Rat Model of Parkinson's Disease

Molecules, 2010
6-Hydroxydopamine administration for 28 days (8 μg/2 μL) reduced the number of tyrosine hydroxylase (TH)-immunopositive neurons to 40.2% in the substantia nigra compared to the intact contralateral side.
Hyun Sook Choi, Mi Sook Park, Seung Hwan Kim, Bang Yeon Hwang, Chong Kil Lee, Myung Koo Lee   +5 more
doaj   +1 more source

Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: Relevance to Parkinson's disease

Neurobiology of Disease, 2005
Cannabinoids have been reported to provide neuroprotection in acute and chronic neurodegeneration. In this study, we examined whether they are also effective against the toxicity caused by 6-hydroxydopamine, both in vivo and in vitro, which may be ...
Isabel Lastres-Becker, Francisco Molina-Holgado, José A. Ramos, Raphael Mechoulam, Javier Fernández-Ruiz   +4 more
doaj   +1 more source

Subtle Cardiovascular Dysfunction in the Unilateral 6-Hydroxydopamine-Lesioned Rat

Parkinson's Disease, 2010
The present study evaluated whether the unilateral 6-hydroxydopamine (6-OHDA) model of Parkinson's disease produces autonomic deficits. Autonomic parameters were assessed by implanting a small radiofrequency telemetry device which measured heart rate ...
K. Slack, R. Billing, S. Matthews, H. N. Allbutt, R. Einstein, J. M. Henderson   +5 more
doaj   +1 more source

RING finger protein 11 (RNF11) modulates susceptibility to 6-OHDA-induced nigral degeneration and behavioral deficits through NF-κB signaling in dopaminergic cells

Neurobiology of Disease, 2013
Chronic activation of the NF-κB pathway is associated with progressive neurodegeneration in Parkinson's disease (PD). Given the role of neuronal RING finger protein 11 (RNF11) as a negative regulator of the NF-κB pathway, in this report we investigated ...
Elaine L. Pranski, Nirjari V. Dalal, Carson Van Sanford, Jeremy H. Herskowitz, Marla Gearing, Carlos Lazo, Gary W. Miller, James J. Lah, Allan I. Levey, Ranjita S. Betarbet   +9 more
doaj   +1 more source

6-hydroxydopamine (6-OHDA) Oxidative Stress Assay for Observing Dopaminergic Neuron Loss in Caenorhabditis elegans

Bio-Protocol, 2018
The nematode Caenorhabditis elegans is a powerful genetic model that can be used to investigate neuronal death. Research using C. elegans has been crucial to characterize cell death programmes that are conserved in mammals.
Sarah-Lena Offenburger, Anton Gartner
doaj   +1 more source

Study on protective effects of Oridonin on 6-hydroxydopamine-induced Parkinson’s disease in matured male rats

Āsīb/shināsī-i Darmāngāhī-i Dāmpizishkī
Background and Objective: Neurological diseases are a growing concern in public health. Recent discoveries have indicated that oxidative stress is a primary driving factor for the onset of these disorders.
Amirhoosein Khalil, Yousef Doustar
doaj