Results 61 to 70 of about 15,615 (185)

Subtle Cardiovascular Dysfunction in the Unilateral 6-Hydroxydopamine-Lesioned Rat

Parkinson's Disease, 2010
The present study evaluated whether the unilateral 6-hydroxydopamine (6-OHDA) model of Parkinson's disease produces autonomic deficits. Autonomic parameters were assessed by implanting a small radiofrequency telemetry device which measured heart rate ...
K. Slack, R. Billing, S. Matthews, H. N. Allbutt, R. Einstein, J. M. Henderson   +5 more
doaj   +1 more source

RING finger protein 11 (RNF11) modulates susceptibility to 6-OHDA-induced nigral degeneration and behavioral deficits through NF-κB signaling in dopaminergic cells

Neurobiology of Disease, 2013
Chronic activation of the NF-κB pathway is associated with progressive neurodegeneration in Parkinson's disease (PD). Given the role of neuronal RING finger protein 11 (RNF11) as a negative regulator of the NF-κB pathway, in this report we investigated ...
Elaine L. Pranski, Nirjari V. Dalal, Carson Van Sanford, Jeremy H. Herskowitz, Marla Gearing, Carlos Lazo, Gary W. Miller, James J. Lah, Allan I. Levey, Ranjita S. Betarbet   +9 more
doaj   +1 more source

Study on protective effects of Oridonin on 6-hydroxydopamine-induced Parkinson’s disease in matured male rats

Āsīb/shināsī-i Darmāngāhī-i Dāmpizishkī
Background and Objective: Neurological diseases are a growing concern in public health. Recent discoveries have indicated that oxidative stress is a primary driving factor for the onset of these disorders.
Amirhoosein Khalil, Yousef Doustar
doaj  

6-hydroxydopamine (6-OHDA) Oxidative Stress Assay for Observing Dopaminergic Neuron Loss in Caenorhabditis elegans

Bio-Protocol, 2018
The nematode Caenorhabditis elegans is a powerful genetic model that can be used to investigate neuronal death. Research using C. elegans has been crucial to characterize cell death programmes that are conserved in mammals.
Sarah-Lena Offenburger, Anton Gartner
doaj   +1 more source

6-Hydroxydopamine and Anticholinergic Drugs [PDF]

Science, 1978
S T, Mason, H C, Fibiger
openaire   +2 more sources

Assessment of Foeniculum Vulgare L. methanolic extract effect on a model of Parkinson’s disease. induced by ICV injection of 6-hydroxydopamin in female rats, using behavioral tests

مجله دانشگاه علوم پزشکی بیرجند, 2015
Background and Aim: Oxidative stresses are involved in neuronal degeneration of substantia nigra and thereby induction of Parkinson's disease. It is reported that Foeniculum Vulgare L.
Hassan Nakisa, Fatemeh Ayoobi, Vahid Ehsani, Mojtaba Akramian, Fatemeh Khajehasani, Mohammadreza Rahmani, Mohammad Allahtavakoli, Ali Shamsizadeh   +7 more
doaj  

Metabotropic Glutamate Receptor 4 (mGlu) Positive Allosteric Modulators Lack Efficacy in Rat and Marmoset Models of L-DOPA-Induced Dyskinesia

Journal of Parkinson’s Disease
Background: Increased activity across corticostriatal glutamatergic synapses may contribute to L-DOPA-induced dyskinesia in Parkinson’s disease. Given the weak efficacy and side-effect profile of amantadine, alternative strategies to reduce glutamate ...
Clare J. Finlay, Michael J. Jackson, Ria Fisher, Christoffer Bundgaard, Sarah Rose, Susan Duty   +5 more
doaj   +1 more source

The Flavonoid Hesperetin Alleviates Behavioral Abnormality in 6-Hydroxydopamine Rat Model of Hemi-Parkinsonism

Basic and Clinical Neuroscience, 2011
Parkinson's disease (PD) is a neuropathological and debilitating disorder involving the degeneration of mesencephalic dopaminergic neurons. Neuroprotective effect of hesperetin has already been reported, therefore, this study examined whether the ...
Tourandokht Baluchnejadmojarad, Mehrdad Roghani   +1 more
doaj  

Dopaminergic Neuroprotection with Ginkgolide in 6-Hydroxydopamine Rat Parkinson’s Disease Model

Journal of Mazandaran University of Medical Sciences, 2019
Background and purpose: Parkinson's disease (PD) is a prevalent movement disorder in elderly with progressive motor complications due to antioxidant defense system deficiency and accumulation of degraded proteins in dopaminergic neurons of midbrain ...
Alireza Moghadam, Ali Noori-Zadeh, Shahram Darabi, Farzad Rajaei, Hojjat-allah Abbaszadeh, Hatef Ghasemi Hamidabadi   +5 more
doaj  

Neuroprotective Effect of Quercetin Nanocrystal in a 6-Hydroxydopamine Model of Parkinson Disease: Biochemical and Behavioral Evidence

Basic and Clinical Neuroscience, 2018
Introduction: studies have suggested that free radicals-induced neurodegeneration is one of the many studies of Parkinson Disease (PD). Quercetin as a natural polyphenol has been regarded as a significant player in altering the progression of ...
Fatemeh Ghaffari, Akbar Hajizadeh Moghaddam, Mahboobeh Zare   +2 more
doaj