Results 61 to 70 of about 14,948 (182)

Assessment of Foeniculum Vulgare L. methanolic extract effect on a model of Parkinson’s disease. induced by ICV injection of 6-hydroxydopamin in female rats, using behavioral tests

مجله دانشگاه علوم پزشکی بیرجند, 2015
Background and Aim: Oxidative stresses are involved in neuronal degeneration of substantia nigra and thereby induction of Parkinson's disease. It is reported that Foeniculum Vulgare L.
Hassan Nakisa, Fatemeh Ayoobi, Vahid Ehsani, Mojtaba Akramian, Fatemeh Khajehasani, Mohammadreza Rahmani, Mohammad Allahtavakoli, Ali Shamsizadeh   +7 more
doaj  

Metabotropic Glutamate Receptor 4 (mGlu) Positive Allosteric Modulators Lack Efficacy in Rat and Marmoset Models of L-DOPA-Induced Dyskinesia

Journal of Parkinson’s Disease
Background: Increased activity across corticostriatal glutamatergic synapses may contribute to L-DOPA-induced dyskinesia in Parkinson’s disease. Given the weak efficacy and side-effect profile of amantadine, alternative strategies to reduce glutamate ...
Clare J. Finlay, Michael J. Jackson, Ria Fisher, Christoffer Bundgaard, Sarah Rose, Susan Duty   +5 more
doaj   +1 more source

6-Hydroxydopamine and Anticholinergic Drugs [PDF]

Science, 1978
S T, Mason, H C, Fibiger
openaire   +2 more sources

The Flavonoid Hesperetin Alleviates Behavioral Abnormality in 6-Hydroxydopamine Rat Model of Hemi-Parkinsonism

Basic and Clinical Neuroscience, 2011
Parkinson's disease (PD) is a neuropathological and debilitating disorder involving the degeneration of mesencephalic dopaminergic neurons. Neuroprotective effect of hesperetin has already been reported, therefore, this study examined whether the ...
Tourandokht Baluchnejadmojarad, Mehrdad Roghani   +1 more
doaj  

Dopaminergic Neuroprotection with Ginkgolide in 6-Hydroxydopamine Rat Parkinson’s Disease Model

Journal of Mazandaran University of Medical Sciences, 2019
Background and purpose: Parkinson's disease (PD) is a prevalent movement disorder in elderly with progressive motor complications due to antioxidant defense system deficiency and accumulation of degraded proteins in dopaminergic neurons of midbrain ...
Alireza Moghadam, Ali Noori-Zadeh, Shahram Darabi, Farzad Rajaei, Hojjat-allah Abbaszadeh, Hatef Ghasemi Hamidabadi   +5 more
doaj  

Parkinson's Disease and the Heart: Studying Cardiac Metabolism in the 6-Hydroxydopamine Model. [PDF]

Int J Mol Sci, 2023
Silva da Fonsêca V, Goncalves VC, Augusto Izidoro M, Guimarães de Almeida AC, Luiz Affonso Fonseca F, Alexandre Scorza F, Finsterer J, Scorza CA.   +7 more
europepmc   +1 more source

Neuroprotective Effect of Quercetin Nanocrystal in a 6-Hydroxydopamine Model of Parkinson Disease: Biochemical and Behavioral Evidence

Basic and Clinical Neuroscience, 2018
Introduction: studies have suggested that free radicals-induced neurodegeneration is one of the many studies of Parkinson Disease (PD). Quercetin as a natural polyphenol has been regarded as a significant player in altering the progression of ...
Fatemeh Ghaffari, Akbar Hajizadeh Moghaddam, Mahboobeh Zare   +2 more
doaj  

Inhibition of neuroinflammation by GIBH-130 (AD-16) reduces neurodegeneration, motor deficits, and proinflammatory cytokines in a hemiparkinsonian model

Frontiers in Neuroanatomy
Parkinson’s disease (PD) is a neurodegenerative condition characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta (SNc) of the brain, manifesting itself with both motor and non-motor symptoms.
Maria E. Bianchetti, Ana Flavia F. Ferreira, Luiz R. G. Britto   +2 more
doaj   +1 more source

Autophagy and neuroprotection in astrocytes exposed to 6-hydroxydopamine is negatively regulated by NQO2: relevance to Parkinson's disease. [PDF]

Sci Rep, 2023
Janda E, Parafati M, Martino C, Crupi F, George William JN, Reybier K, Arbitrio M, Mollace V, Boutin JA.   +8 more
europepmc   +1 more source

Irisin reduces neurodegeneration and neuroinflammation in the 6-hydroxydopamine rat model of Parkinson’s disease

Brain Research Bulletin
Parkinson’s disease (PD) is a progressive neurodegenerative disorder that affects millions of individuals worldwide. With the number of cases expected to continue rising, there is an urgent need for new treatments.
Nicole M. Kamidai, Luiz Roberto G. Britto, Ana Flávia F. Ferreira   +2 more
doaj   +1 more source