Results 11 to 20 of about 14,948 (182)
The oxidation of 6-hydroxydopamine
Journal of Pharmacy and Pharmacology, 1973 AbstractThe oxidation of 6-hydroxydopamine (I) with molecular oxygen or potassium ferricyanide in aqueous solution has been shown to lead mainly to the formation of the uncyclized quinone 2-(β-aminoethyl)-5-hydroxy-p-benzoquinone (VII). However this quinone cyclized slowly, presumably to norepinochrome (i.e.
W S, Powell, R A, Heacock
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BMC Complementary Medicine and Therapies, 2022 Background Parkinson’s disease (PD) is a multifactorial movement disorder with the progressive degeneration of the nigrostriatal system that impairs patients’ movement ability. Oxidative stress has been found to affect the etiology and pathogenesis of PD.
Saeideh Nourmohammadi +5 more
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One-Electron Reduction of 6-Hydroxydopamine Quinone is Essential in 6-Hydroxydopamine Neurotoxicity
Neurotoxicity Research, 2013 6-Hydroxydamine has widely been used as neurotoxin in preclinical studies related on the neurodegenerative process of dopaminergic neurons in Parkinson's disease based on its ability to be neurotoxic as a consequence of free radical formation during its auto-oxidation to topaminequinone.
Villa, Monica +7 more
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Frontiers in Aging Neuroscience, 2020 BackgroundSpinal cord stimulation (SCS) exerts neuroprotective effects in animal models of Parkinson’s disease (PD). Conventional stimulation techniques entail limited stimulation time and restricted movement of animals, warranting the need for ...
Ken Kuwahara +17 more
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Neural Regeneration Research, 2016 Striatal neurons can be either projection neurons or interneurons, with each type exhibiting distinct susceptibility to various types of brain damage. In this study, 6-hydroxydopamine was injected into the right medial forebrain bundle to induce dopamine
Jia-jia Wu +11 more
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Chinese Journal of Physiology, 2021 Accumulating evidence has already indicated that traditional Chinese medicine (TCM) possesses tremendous potential for treating neurodegenerative diseases.
Li-Ying Guo +5 more
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Journal of Pharmacological Sciences, 2006 DJ-1 has multiple functions and its dysfunction may be linked to the onset of familial Parkinson’s disease PARK7. However, the function and distribution of DJ-1 is unclear.
Takashi Yanagida +7 more
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The Effect of Chronic Administration of Buspirone on 6-Hydroxydopamine-Induced Catalepsy in Rats [PDF]
Advanced Pharmaceutical Bulletin, 2012 Purpose: Several evidences show that serotonergic neurons play a role in the regulation of movements executed by the basal ganglia. Recently we have reported that single dose of buspirone improved 6-hydroxydopamine (6-OHDA) and haloperidol-induced ...
Hamdolah Sharifi +2 more
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Baicalein Prevents 6-Hydroxydopamine-Induced Dopaminergic Dysfunction and Lipid Peroxidation in Mice
Journal of Pharmacological Sciences, 2005 The effects of baicalein on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity were evaluated. Intracerebroventricularly (i.c.v.) injection of 6-OHDA was done to young mice. Baicalein was administered intraperitoneally 30 min before and 90 min after i.c.v.
Heh-In Im +5 more
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N-acetylcysteine protects against motor, optomotor and morphological deficits induced by 6-OHDA in zebrafish larvae [PDF]
PeerJ, 2018 Background Parkinson’s disease (PD) is the second most common neurodegenerative disorder. In addition to its highly debilitating motor symptoms, non-motor symptoms may precede their motor counterparts by many years, which may characterize a prodromal ...
Radharani Benvenutti +7 more
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