Results 11 to 20 of about 15,615 (185)
BMC Complementary Medicine and Therapies, 2022 Background Parkinson’s disease (PD) is a multifactorial movement disorder with the progressive degeneration of the nigrostriatal system that impairs patients’ movement ability. Oxidative stress has been found to affect the etiology and pathogenesis of PD.
Saeideh Nourmohammadi +5 more
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Neural Regeneration Research, 2016 Striatal neurons can be either projection neurons or interneurons, with each type exhibiting distinct susceptibility to various types of brain damage. In this study, 6-hydroxydopamine was injected into the right medial forebrain bundle to induce dopamine
Jia-jia Wu +11 more
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Translational Neurodegeneration, 2018 Background Abnormal expression of major histocompatibility complex class I (MHC-I) is increased in dopaminergic (DA) neurons in the substantia nigra (SN) in Parkinson’s disease (PD).
Ming-Shu Mo +13 more
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Frontiers in Aging Neuroscience, 2020 BackgroundSpinal cord stimulation (SCS) exerts neuroprotective effects in animal models of Parkinson’s disease (PD). Conventional stimulation techniques entail limited stimulation time and restricted movement of animals, warranting the need for ...
Ken Kuwahara +17 more
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Journal of Pharmacological Sciences, 2006 DJ-1 has multiple functions and its dysfunction may be linked to the onset of familial Parkinson’s disease PARK7. However, the function and distribution of DJ-1 is unclear.
Takashi Yanagida +7 more
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Chinese Journal of Physiology, 2021 Accumulating evidence has already indicated that traditional Chinese medicine (TCM) possesses tremendous potential for treating neurodegenerative diseases.
Li-Ying Guo +5 more
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The Effect of Chronic Administration of Buspirone on 6-Hydroxydopamine-Induced Catalepsy in Rats [PDF]
Advanced Pharmaceutical Bulletin, 2012 Purpose: Several evidences show that serotonergic neurons play a role in the regulation of movements executed by the basal ganglia. Recently we have reported that single dose of buspirone improved 6-hydroxydopamine (6-OHDA) and haloperidol-induced ...
Hamdolah Sharifi +2 more
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Baicalein Prevents 6-Hydroxydopamine-Induced Dopaminergic Dysfunction and Lipid Peroxidation in Mice
Journal of Pharmacological Sciences, 2005 The effects of baicalein on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity were evaluated. Intracerebroventricularly (i.c.v.) injection of 6-OHDA was done to young mice. Baicalein was administered intraperitoneally 30 min before and 90 min after i.c.v.
Heh-In Im +5 more
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N-acetylcysteine protects against motor, optomotor and morphological deficits induced by 6-OHDA in zebrafish larvae [PDF]
PeerJ, 2018 Background Parkinson’s disease (PD) is the second most common neurodegenerative disorder. In addition to its highly debilitating motor symptoms, non-motor symptoms may precede their motor counterparts by many years, which may characterize a prodromal ...
Radharani Benvenutti +7 more
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Ghrelin alleviates 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells
Neural Regeneration Research, 2022 Ghrelin is a neuropeptide that has various physiological functions and has been demonstrated to be neuroprotective in a number of neurological disease models. However, the underlying mechanisms of ghrelin in Parkinson’s disease remain largely unexplored.
Xin He +6 more
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