Subtle Cardiovascular Dysfunction in the Unilateral 6-Hydroxydopamine-Lesioned Rat
Parkinson's Disease, 2010 The present study evaluated whether the unilateral 6-hydroxydopamine (6-OHDA) model of Parkinson's disease produces autonomic deficits. Autonomic parameters were assessed by implanting a small radiofrequency telemetry device which measured heart rate ...
K. Slack +5 more
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Neurobiology of Disease, 2005 Cannabinoids have been reported to provide neuroprotection in acute and chronic neurodegeneration. In this study, we examined whether they are also effective against the toxicity caused by 6-hydroxydopamine, both in vivo and in vitro, which may be ...
Isabel Lastres-Becker +4 more
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اثرات محافظتی عصاره گل گياه ازگيل ژاپنی بر سطوح MANF ساقه مغز در برابر سم 6- هيدروکسی دوپامين در رت [PDF]
, 2014 زمينه و هدف : استرس اکسايشی در آبشار منتهی به تحليل نورون دوپامينی در بيماری پارکينسون، مشارکت دارد. عصاره هيدروالکی گل گياه ازگيل ژاپنی غنی از ترکيبات فنولی است.
آقاسی, محمد +2 more
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alpha-lipoic acid suppresses 6-hydroxydoparnine-induced ROS generation and apoptosis through the stimulation of glutathione synthesis but not by the expression of heme oxygenase-1 [PDF]
, 2008 We previously reported that the generation of reactive oxygen species (ROS) is the initial event in cell death induced by 6-hydroxydopamine (6-OHDA), an experimental model of Parkinsonism.
Akagi, Reiko +9 more
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Neurobiology of Disease, 2013 Chronic activation of the NF-κB pathway is associated with progressive neurodegeneration in Parkinson's disease (PD). Given the role of neuronal RING finger protein 11 (RNF11) as a negative regulator of the NF-κB pathway, in this report we investigated ...
Elaine L. Pranski +9 more
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Romidepsin induces caspase-dependent cell death in human neuroblastoma cells [PDF]
, 2017 Neuroblastoma is the most common extracranial pediatric solid tumor, arising from the embryonic sympathoadrenal lineage of the neural crest, and is responsible for 15% of childhood cancer deaths.
Hegarty, Shane V. +5 more
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Bio-Protocol, 2018 The nematode Caenorhabditis elegans is a powerful genetic model that can be used to investigate neuronal death. Research using C. elegans has been crucial to characterize cell death programmes that are conserved in mammals.
Sarah-Lena Offenburger, Anton Gartner
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Effects of bacterial lipopolysaccharide exposure on immune responsiveness in a rodent model of Parkinson’s disease [PDF]
, 2011 The effects of lipopolysaccharide (LPS) on immune modulation in rats subjected to a right-unilateral lesion of the substantia nigra neurons by means of 6-hydroxydopamine (6-OHDA), were investigated.
Ciobica A. +4 more
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Neuronal entropy depends on the level of alertness in the parkinsonian globus pallidus in vivo [PDF]
, 2014 A new working hypothesis of Parkinson's disease (PD) proposes to focus on the central role of entropy increase in the basal ganglia (BG) in movement disorders. The conditions necessary for entropy increase in vivo are, however, still not fully described.
Andres, Daniela Sabrina +3 more
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Transcriptional alterations under continuous or pulsatile dopaminergic treatment in dyskinetic rats [PDF]
, 2018 Continuous dopaminergic treatment is considered to prevent or delay the occurrence of dyskinesia in patients with Parkinson's disease (PD). Rotigotine is a non-ergolinic D3>D2>D1 dopamine-receptor agonist for the treatment of PD using a transdermal ...
Gerlach, M. +4 more
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