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Mechanism of 6-hydroxydopamine neurotoxicity
1997The catecholaminergic neurotoxin 6-hydroxydopamine (6-OHDA) has recently been found to be formed endogenously in patients suffering from Parkinson's disease. In this article, we highlight the latest findings on the biochemical mechanism of 6-OHDA toxicity.
Y, Glinka, M, Gassen, M B, Youdim
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Central cardiovascular effects of 6-hydroxydopamine
European Journal of Pharmacology, 1972Abstract Effects of 6-hydroxydopamine (6-OHDA) on the vasomotor loci of medulla oblongata, hypothalamus and spinal cord have been investigated in anaesthetized (chloralosed) cats. Intracerebroventricular (i.c.v.) and intrathecal (i.t.) administration of 6-OHDA, 0.5–2.0 mg, inhibited reflex, as well as direct, excitability of vasomotor loci. The blood
P P, Gupta, R C, Srimal, B N, Dhawan
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Oxidation of 6-hydroxydopamine catalyzed by tyrosinase
International Journal of Biochemistry, 19931. The oxidation of 3,4-dihydroxyphenylethylamine (dopamine) by O2 catalyzed by tyrosinase yields 4-(2-aminoethyl)-1,2-benzoquinone, with its amino group protonated (o-dopaminequinone-H+), which evolves non-enzymatically through two branches or sequences of reactions, whose respective operations are determined by the pH of the medium. 2.
J N, Rodriguez-López +2 more
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2000
Abstract 6-Hydroxydopamine (6-OH-DA) was originally synthesized in 1959 (38,39); the authors suggested that 6-OH-DA might be a naturally occurring oxidation product/metabolite of its congener dopamine. Systemic administration of 6-OH-DA caused a long-lasting depletion of noradrenaline from sympathetically innervated organs (28,32,42).
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Abstract 6-Hydroxydopamine (6-OH-DA) was originally synthesized in 1959 (38,39); the authors suggested that 6-OH-DA might be a naturally occurring oxidation product/metabolite of its congener dopamine. Systemic administration of 6-OH-DA caused a long-lasting depletion of noradrenaline from sympathetically innervated organs (28,32,42).
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Perinatal 6-Hydroxydopamine Modeling of ADHD
2015The neonatally 6-hydroxydopamine (n6-OHDA)-lesioned rat has been the standard for 40 years, as an animal model of attention-deficit hyperactivity disorder (ADHD). Rats so lesioned during postnatal ontogeny are characterized by ~99 % destruction of dopaminergic nerves in pars compacta substantia nigra, with comparable destruction of the nigrostriatal ...
Kostrzewa, John P. +4 more
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A New Synthesis of 6-Hydroxydopamine
Canadian Journal of Chemistry, 1972An efficient synthesis of 6-hydroxydopamine is described. The key step involves oxidation of an N-protected 3-hydroxy-4-methoxyphenethylamine to the corresponding p-quinone by means of Fremy's salt.
Pius A. Wehrli, F. Pigott, V. Chu
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6-Hydroxydopamine: a far from simple neurotoxin
Journal of Neural Transmission, 20206-Hydroxydopamine (6-OHDA), which is a neurotoxin that selectively destroys catecholaminergic nerves in sympathetically innervated tissues, has been used to provide a model of Parkinson's disease in experimental animals. It is rapidly autoxidised to yield potentially toxic products and reactive oxygen species. Its ability to release Fe(II) from protein
Damir Varešlija +3 more
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Effects of 6-hydroxydopamine on spontaneously hypertensive rats
Naunyn-Schmiedeberg's Archives of Pharmacology, 1974In order to evaluate the role of the sympathetic nervous system in the development and maintenance of spontaneous hypertension, spontaneously hypertensive and normotensive rats were give 6-hydroxydopamine (6-OH-dopamine). A single i.v. dose of 6-OH-dopamine (100 mg/kg) caused a biphasic rise in blood pressure in both hypertensive and normotensive rats.
H, Vapaatalo +4 more
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The 6-hydroxydopamine model: News from the past
Parkinsonism & Related Disorders, 2008The investigation of pathogenic and pathophysiological mechanisms of Parkinson's disease relies on experimental models reproducing, in the animal, the pathological and behavioural features of the disease. Despite the availability of innovative models, 6-hydroxydopamine (6-OHDA) remains the most widely used tool to induce a nigrostriatal lesion in the ...
Blandini F. +2 more
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6-Hydroxydopamine produces a weight increase in toads
Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1983A large increase in body weight occurred after injection of 6-hydroxydopamine (6-OHDA, 100 mg kg-1) into the iliac lymph sac of toads. The body weight increase was apparently due to retention of fluid and only occurred when toads could not avoid contact of their ventral skin with water.
J, Clevers, J L, Morris
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