Results 131 to 140 of about 15,615 (185)
Some of the next articles are maybe not open access.
6-Hydroxydopamine and Aggression in Cats
Pharmacology Biochemistry and Behavior, 1981The effect of 6-hydroxydopamine (6-OHDA) injected into the cerebral ventricles on behaviour of singly- and group-housed cats was investigated. 6-OHDA in doses of 0.5, 1 and 2 mg was administered every morning for 5 to 8 days. In small doses 6-OHDA in singly- and group-housed cats evoked motor phenomena such as tremor, ataxia, rigidity, weakness and ...
D B, Beleslin +2 more
openaire +2 more sources
Psychopharmacology, 1980
After intracisternal 6-hydroxydopamine (6-OHDA) in mice, brain noradrenaline (NA) and dopamine (DA) are diminished, although the reduction of NA is more pronounced. Intracisternal injection of 6-OHDA in desmethylimipramine (DMI)-pretreated animals strengthens the depletion of DA while NA is partly protected.
V, Fuchs, H, Coper
openaire +2 more sources
After intracisternal 6-hydroxydopamine (6-OHDA) in mice, brain noradrenaline (NA) and dopamine (DA) are diminished, although the reduction of NA is more pronounced. Intracisternal injection of 6-OHDA in desmethylimipramine (DMI)-pretreated animals strengthens the depletion of DA while NA is partly protected.
V, Fuchs, H, Coper
openaire +2 more sources
The 6-Hydroxydopamine model of parkinson’s disease
Neurotoxicity Research, 2007The neurotoxin 6-hydroxydopamine (6-OHDA) continues to constitute a valuable topical tool used chiefly in modeling Parkinson's disease in the rat. The classical method of intracerebral infusion of 6-OHDA involving a massive destruction of nigrostriatal dopaminergic neurons, is largely used to investigate motor and biochemical dysfunctions in Parkinson ...
SIMOLA, NICOLA +2 more
openaire +4 more sources
Effects of 6-Hydroxydopamine on Sleep in the Rat
Nature, 1971THERE is evidence that biogenic amines are involved in the mechanisms of sleep1,2. Although the exact relationship is not clear, recent results suggest that decreases in the concen-tration of catecholamines (noradrenaline or dopamine) in the brain cause increased desynchronized sleep (D) (sleep with rapid desynchronized cortical activity, also known as
E, Hartmann +3 more
openaire +2 more sources
Central cardiovascular effects of 6-hydroxydopamine
European Journal of Pharmacology, 1972Abstract Effects of 6-hydroxydopamine (6-OHDA) on the vasomotor loci of medulla oblongata, hypothalamus and spinal cord have been investigated in anaesthetized (chloralosed) cats. Intracerebroventricular (i.c.v.) and intrathecal (i.t.) administration of 6-OHDA, 0.5–2.0 mg, inhibited reflex, as well as direct, excitability of vasomotor loci. The blood
P P, Gupta, R C, Srimal, B N, Dhawan
openaire +2 more sources
Mechanism of 6-hydroxydopamine neurotoxicity
1997The catecholaminergic neurotoxin 6-hydroxydopamine (6-OHDA) has recently been found to be formed endogenously in patients suffering from Parkinson's disease. In this article, we highlight the latest findings on the biochemical mechanism of 6-OHDA toxicity.
Y, Glinka, M, Gassen, M B, Youdim
openaire +2 more sources
Oxidation of 6-hydroxydopamine catalyzed by tyrosinase
International Journal of Biochemistry, 19931. The oxidation of 3,4-dihydroxyphenylethylamine (dopamine) by O2 catalyzed by tyrosinase yields 4-(2-aminoethyl)-1,2-benzoquinone, with its amino group protonated (o-dopaminequinone-H+), which evolves non-enzymatically through two branches or sequences of reactions, whose respective operations are determined by the pH of the medium. 2.
J N, Rodriguez-López +2 more
openaire +2 more sources
2000
Abstract 6-Hydroxydopamine (6-OH-DA) was originally synthesized in 1959 (38,39); the authors suggested that 6-OH-DA might be a naturally occurring oxidation product/metabolite of its congener dopamine. Systemic administration of 6-OH-DA caused a long-lasting depletion of noradrenaline from sympathetically innervated organs (28,32,42).
openaire +1 more source
Abstract 6-Hydroxydopamine (6-OH-DA) was originally synthesized in 1959 (38,39); the authors suggested that 6-OH-DA might be a naturally occurring oxidation product/metabolite of its congener dopamine. Systemic administration of 6-OH-DA caused a long-lasting depletion of noradrenaline from sympathetically innervated organs (28,32,42).
openaire +1 more source
Perinatal 6-Hydroxydopamine Modeling of ADHD
2015The neonatally 6-hydroxydopamine (n6-OHDA)-lesioned rat has been the standard for 40 years, as an animal model of attention-deficit hyperactivity disorder (ADHD). Rats so lesioned during postnatal ontogeny are characterized by ~99 % destruction of dopaminergic nerves in pars compacta substantia nigra, with comparable destruction of the nigrostriatal ...
Kostrzewa, John P. +4 more
openaire +3 more sources
6-Hydroxydopamine: a far from simple neurotoxin
Journal of Neural Transmission, 20206-Hydroxydopamine (6-OHDA), which is a neurotoxin that selectively destroys catecholaminergic nerves in sympathetically innervated tissues, has been used to provide a model of Parkinson's disease in experimental animals. It is rapidly autoxidised to yield potentially toxic products and reactive oxygen species. Its ability to release Fe(II) from protein
Damir Varešlija +3 more
openaire +2 more sources