Results 141 to 150 of about 15,615 (185)
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A New Synthesis of 6-Hydroxydopamine
Canadian Journal of Chemistry, 1972An efficient synthesis of 6-hydroxydopamine is described. The key step involves oxidation of an N-protected 3-hydroxy-4-methoxyphenethylamine to the corresponding p-quinone by means of Fremy's salt.
Pius A. Wehrli, F. Pigott, V. Chu
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Effect of 6-hydroxydopamine on retinal development in the chick
Experientia, 1974Huhnerembryonen wurden am 3. und 8. Inkubationstag mit 6-Hydroxydopamin behandelt. Die histologische Analyse der Retina ergab am 19. Tag eine charakteristische Hemmung der Photorezeptoren (Stabchen und Zapfen).
D T, Yew, A K, Ho, D B, Meyer
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Effect of 6-hydroxydopamine on morphine analgesia
Psychopharmacologia, 1972The influence of 6-OHDA on morphine analgesia estimated by the hot-plate method was investigated in rats. 6-OHDA injected intraventricularly at a dose of 250 Μg/rat, significantly and specifically depleted catecholamines from the brain. Morphine (7.5 mg/kg) produced a prominent analgesia in untreated and sham-injected rats whilst the reaction times of ...
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6-Hydroxydopamine produces a weight increase in toads
Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1983A large increase in body weight occurred after injection of 6-hydroxydopamine (6-OHDA, 100 mg kg-1) into the iliac lymph sac of toads. The body weight increase was apparently due to retention of fluid and only occurred when toads could not avoid contact of their ventral skin with water.
J, Clevers, J L, Morris
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The Effect of 6-Hydroxydopamine on the Rabbit Cochlea
Acta Oto-Laryngologica, 19756-OH-DA is an isomer of noradrenalin which is selectively taken up by adrenergic axons. Noradrenalin stores are displaced by 6-OH-DA and at a certain intraneuronal concentration, degeneration of the terminals occurs and results in a chemical sympathectomy.
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The effect of 6-hydroxydopamine on the antinociceptive action of morphine
European Journal of Pharmacology, 1978The role of brain catecholamines in the antinociceptive action of morphine was investigated. Intraventricular 6-hydroxydopamine which depleted brain noradrenaline in the rat had no effect on morphine's antinociceptive action but combined treatment with pargyline and 6-hydroxydopamine to further deplete brain dopamine potentiated morphine's action.
P, Slater, C, Blundell
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Chemical Sympathectomy with 6-Hydroxydopamine
1970The removal or destruction of an organ to elucidate its physiological role is one of the oldest and most commonly used methods in biological research. This principle has found extensive application in the investigation of the physiology and pharmacology of the sympathetic nervous system [Cannon and Rosenblueth, 1949; Trendelenburg, 1963 (1, 2)].
H. Thoenen, J. P. Tranzer, G. Häusler
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Extracellular toxicity of 6-hydroxydopamine on PC12 cells
Neuroscience Letters, 20006-hydroxydopamine (6-OHDA) is usually thought to cross cell membrane through dopamine uptake transporters, to inhibit mitochondrial respiration and to generate intracellular reactive oxygen species. In this study, we show that the anti-oxidants catalase, glutathione and N-acetyl-cysteine are able to reverse the toxic effects of 6-OHDA. These two latter
Blum, David +4 more
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The stability of 6-hydroxydopamine under minipump conditions
Experimental Brain Research, 1984A number of investigators have recently used osmotic minipumps to continuously deliver the neurotoxin 6-hydroxydopamine (6-OHDA) to kitten cerebral cortex for periods up to 7 days. Because this compound is known to be particularly labile, we studied the stability of 6-OHDA stored under conditions similar to those found in an osmotic minipump.
D A, Haycock, M F, Bear
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Effect of ceruloplasmin on 6-hydroxydopamine oxidation.
Biochemistry and molecular biology international, 1996The effects of ceruloplasmin, a blu copper-containing serum glycoprotein, on the oxidation of the neurotoxin 6-hydroxydopamine in several chemical environments were studied. The spontaneous autoxidation of 6-hydroxydopamine proceeded by a free radical chain reaction involving O2-.
MEDDA, ROSARIA +4 more
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