Results 181 to 190 of about 32,355 (207)
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Perinatal 6-Hydroxydopamine Modeling of ADHD
2015The neonatally 6-hydroxydopamine (n6-OHDA)-lesioned rat has been the standard for 40 years, as an animal model of attention-deficit hyperactivity disorder (ADHD). Rats so lesioned during postnatal ontogeny are characterized by ~99 % destruction of dopaminergic nerves in pars compacta substantia nigra, with comparable destruction of the nigrostriatal ...
Kostrzewa, John P. +4 more
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l-DOPA administration enhances 6-hydroxydopamine generation
Brain Research, 2005The therapeutic success of L-3,4-dihydroxyphenylalanine (L-DOPA) treatment in Parkinson's disease (PD) patients remains controversial as many patients become tolerant requiring higher dosage regimens. However, the increase in dosage regimens results in the patients experiencing intolerable side effects. This study sought to investigate whether dopamine
Himant, Maharaj +4 more
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Behavioural effects of neonatal systemic 6-hydroxydopamine
Neuropharmacology, 1978Abstract Rats were injected systemically (2 × 50 μg/g) with 6-hydroxydopamine either on the first, fifth or tenth day of life. Whereas brain dopamine was generally unaffected, norepinephrine assays during adult-hood showed age-dependent effects of the injections, with the greatest effect observed after injections on day 1.
M, Saari, B A, Pappas
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Dexmedetomidine Regulates 6-hydroxydopamine-Induced Microglial Polarization
Neurochemical Research, 2017Microglia have undergone extensive characterization and have been shown to present distinct phenotypes, such as the M1 or M2 phenotypes, depending on their stimuli. As a highly specific neurotoxin, 6-hydroxydopamine (6-OHDA) can be used to further our understanding of the immune response in Parkinson's disease (PD).
Pei, Zhang +4 more
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Iron protects astrocytes from 6-hydroxydopamine toxicity
Neuropharmacology, 2005The role of iron in 6-hydroxydopamine (6-OHDA) toxicity towards astrocytes was investigated in vitro using rat primary astrocytes, rat astrocytoma cell line C6, and human astrocytoma cell line U251. The assessment of mitochondrial respiration or lactate dehydrogenase release has shown a dose-dependent decrease in the viability of astrocytes treated ...
Zogović, Nevena +5 more
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Phosphorylation of p66shc mediates 6-hydroxydopamine cytotoxicity
Free Radical Research, 20106-Hydroxydopamine (6-OHDA) is a neurotoxin that has been widely used to generate Parkinson's disease (PD) models. Increased oxidative stress is suggested to play an important role in 6-OHDA-induced cell death. Given the lessened susceptibility to oxidative stress exhibited by mice lacking p66shc, this study investigated the role of p66shc in the ...
Tohru, Yamamori +6 more
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Free Radical‐Generated Neurotoxicity of 6‐Hydroxydopamine
Journal of Neurochemistry, 1995Abstract: Albino rats were lesioned bilaterally with 6‐hydroxydopamine (6‐OHDA) hydrochloride (4 µg/µl, dissolved in saline with 0.1% ascorbic acid) into the striatum, and 72 h after the injection, levels of lipid peroxidation, GSH, superoxide dismutase (SOD), glutathione peroxidase (GSH‐Px), lipid class, membrane fluidity, and intracellular calcium ...
R, Kumar, A K, Agarwal, P K, Seth
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Chemical Sympathectomy with 6-Hydroxydopamine
1970The removal or destruction of an organ to elucidate its physiological role is one of the oldest and most commonly used methods in biological research. This principle has found extensive application in the investigation of the physiology and pharmacology of the sympathetic nervous system [Cannon and Rosenblueth, 1949; Trendelenburg, 1963 (1, 2)].
H. Thoenen, J. P. Tranzer, G. Häusler
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6-Hydroxydopamine induces thymocyte apoptosis in mice
Journal of Neuroimmunology, 19966-Hydroxydopamine (6-OHDA) induces degeneration of noradrenergic nerves and has been shown to alter the immune responses. In this study, intraperitoneal administration of 6-OHDA induces mouse thymus atrophy. The lowest levels of thymus weight and cell number were reached at days 3 and 5 in mice receiving 6-OHDA treatment; they gradually recovered ...
C W, Tsao +3 more
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Oxidation of 6-hydroxydopamine catalyzed by tyrosinase
International Journal of Biochemistry, 19931. The oxidation of 3,4-dihydroxyphenylethylamine (dopamine) by O2 catalyzed by tyrosinase yields 4-(2-aminoethyl)-1,2-benzoquinone, with its amino group protonated (o-dopaminequinone-H+), which evolves non-enzymatically through two branches or sequences of reactions, whose respective operations are determined by the pH of the medium. 2.
J N, Rodriguez-López +2 more
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