Results 1 to 10 of about 751 (132)

Impact of supervisors' research style on young biomedical scientists' capacity development as measured by REDi, a novel index of crossdisciplinarity [PDF]

open access: yesFrontiers in Research Metrics and Analytics, 2022
The challenge for medical schools in Japan is to develop research activities for innovation. This study aimed at analyzing the connection between the research output of “promising researchers” (next-generation leaders in terms of research activity) and ...
Akiko Hashiguchi   +3 more
doaj   +2 more sources

Semiparametric discovery and estimation of interaction in mixed exposures using stochastic interventions [PDF]

open access: yesJournal of Causal Inference
Understanding the complex interactions among multiple environmental exposures is critical for assessing their combined impact on health outcomes. This study introduces InterXshift, a novel semiparametric method that provides a nonparametric definition of
McCoy David B.   +3 more
doaj   +2 more sources

Discovery of critical thresholds in mixed exposures and estimation of policy intervention effects [PDF]

open access: yesJournal of Causal Inference
Regulations of chemical exposures often focus on individual substances, neglecting the amplified toxicity that can arise from multiple concurrent exposures.
McCoy David B.   +3 more
doaj   +2 more sources

Sequence alignment generation using intermediate sequence search for homology modeling [PDF]

open access: yesComputational and Structural Biotechnology Journal, 2020
Protein tertiary structure is important information in various areas of biological research, however, the experimental cost associated with structure determination is high, and computational prediction methods have been developed to facilitate a more ...
Shuichiro Makigaki, Takashi Ishida
doaj   +2 more sources

Assessing surrogate heterogeneity in real world data using meta-learners [PDF]

open access: yesJournal of Causal Inference
Surrogate markers are most commonly studied within the context of randomized clinical trials. However, the need for alternative outcomes also extends to real-world public health and social science research, where randomized trials are often impractical ...
Knowlton Rebecca, Parast Layla
doaj   +2 more sources

The structural properties of the Gompertz-two-parameter-Lindley distribution and associated inference

open access: yesOpen Mathematics, 2022
In this article, we propose a Gompertz-two-parameter-Lindley distribution by mixing the frailty parameter of the Gompertz distribution with a two-parameter Lindley distribution. The structural properties of the model, such as shape properties, cumulative
Ou Xionghui, Lu Hezhi, Kong Jingsen
doaj   +1 more source

Asymptotic normality of the relative error regression function estimator for censored and time series data

open access: yesDependence Modeling, 2021
Consider a survival time study, where a sequence of possibly censored failure times is observed with d-dimensional covariate The main goal of this article is to establish the asymptotic normality of the kernel estimator of the relative error regression ...
Bouhadjera Feriel, Saïd Elias Ould
doaj   +1 more source

Decomposition of the total effect for two mediators: A natural mediated interaction effect framework

open access: yesJournal of Causal Inference, 2022
Mediation analysis has been used in many disciplines to explain the mechanism or process that underlies an observed relationship between an exposure variable and an outcome variable via the inclusion of mediators.
Gao Xin, Li Li, Luo Li
doaj   +1 more source

Evolutionary trend of SARS-CoV-2 inferred by the homopolymeric nucleotide repeats

open access: yesComputational and Mathematical Biophysics, 2022
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the current global COVID-19 pandemic, in which millions of lives have been lost.
Yin Changchuan
doaj   +1 more source

Attributable fraction and related measures: Conceptual relations in the counterfactual framework

open access: yesJournal of Causal Inference, 2023
The attributable fraction (population) has attracted much attention from a theoretical perspective and has been used extensively to assess the impact of potential health interventions. However, despite its extensive use, there is much confusion about its
Suzuki Etsuji, Yamamoto Eiji
doaj   +1 more source

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