Results 121 to 130 of about 23,617 (228)

Propranolol treatment of infantile hemangioma endothelial cells: A molecular analysis [PDF]

, 2014
Infantile hemangiomas (IHs) are non-malignant, largely cutaneous vascular tumors affecting approximately 5–10% of children to varying degrees. During the first year of life, these tumors are strongly proliferative, reaching an average size ranging from 2
AMAYA, CLARISSA, BISCHOFF, JOYCE, BOUCHERON, LAURA E., BRYAN, BRAD A., KOKTA, VICTOR, LACAZE, MARY, MITCHELL, DIANNE C., MULNE, ARLYNN, PHAM, ROBERT, ROWNTREE, REBECCA K., STILES, JESSICA   +10 more
core   +1 more source

Effect of DHCR7 on adipocyte differentiation in goats

Animal Biotechnology
Cholesterol is regarded as a signaling molecule in regulating the metabolism and function of fat cells, in which 7-Dehydrocholesterol reductase (DHCR7) is a key enzyme that catalyzes the conversion of 7-dehydrocholesterol to cholesterol, however, the ...
Zhibin Li, Tingting Hu, Ruiwen Li, Jinlan Li, Youli Wang, Yanyan Li, Yaqiu Lin, Yong Wang, Xing Jiani   +8 more
doaj   +1 more source

Metabolic engineering of Saccharomyces cerevisiae for 7-dehydrocholesterol overproduction

Biotechnology for Biofuels, 2018
Background 7-Dehydrocholesterol (7-DHC) has attracted increasing attentions due to its great medical value and the enlarging market demand of its ultraviolet-catalyzed product vitamin D3.
Xiao-Jing Guo, Wen-Hai Xiao, Ying Wang, Ming-Dong Yao, Bo-Xuan Zeng, Hong Liu, Guang-Rong Zhao, Ying-Jin Yuan   +7 more
doaj   +1 more source

RETRACTED ARTICLE: Age-dependent Increase in Desmosterol Restores DRM Formation and Membrane-related Functions in Cholesterol-free DHCR24−/− Mice [PDF]

, 2018
Cholesterol is a prominent modulator of the integrity and functional activity of physiological membranes and the most abundant sterol in the mammalian brain. DHCR24-knock-out mice lack cholesterol and accumulate desmosterol with age.
Crameri, Arames, Heppner, Frank, Kalvodova, Lucie, Kuehnle, Katrin, Kulic, Luka, Ledesma, Maria, Lütjohann, Dieter, Mohajeri, M., Nitsch, Roger, Skaanes-Brunner, Fabienne, Smith, Alicia, Thelen, Karin   +11 more
core  

Cholic acid increases plasma cholesterol in Smith-Lemli-Opitz syndrome: A pilot study

Molecular Genetics and Metabolism Reports
Background: Smith-Lemli-Opitz syndrome (SLOS) is an inherited disorder of cholesterol biosynthesis associated with congenital malformations, growth delay, intellectual disability and behavior problems.
Ellen R. Elias, Lucas E. Orth, Amy Li, Libin Xu, Sara M. Jones, William B. Rizzo   +5 more
doaj   +1 more source

Oxysterols and Retinal Degeneration in a Rat Model of Smith-Lemli-Opitz Syndrome: Implications for an Improved Therapeutic Intervention

Molecules, 2018
Smith-Lemli-Opitz syndrome (SLOS) is an autosomal recessive human disease caused by mutations in the gene encoding 7-dehydrocholesterol (7DHC) reductase (DHCR7), resulting in abnormal accumulation of 7DHC and reduced levels of cholesterol in bodily ...
Steven J. Fliesler, Libin Xu
doaj   +1 more source

Post-translational switch of DHCR24 acetylation sustains sterol synthesis and promotes HCC via the 7-ketocholesterol/p62 axis

Cell Reports
Summary: Dysregulated cholesterol synthesis fuels cancer progression, but its precise role in hepatocellular carcinoma (HCC) remains unclear. Here, we identify elevated acetylation of 24-dehydrocholesterol reductase (DHCR24) at Lys254 as a hallmark of ...
Yunfei Zhou, Xinxin Yang, Jianwen Xu, Yidi Wu, Yin Fu, Yihong Dong, Xun Yang, Qiang Fu, Chenxu Guo, Yunjing Hou, Shuyuan Chang, Jun Yan, Ju Ran, Yumeng Wang, Qingxin Zhang, Tomii Ayaka, Lei Yu, Feng Geng, Liuyang Zhao, Xiaoyang Hu, Shuijie Li, Hongxue Meng, Dabin Liu   +22 more
doaj   +1 more source

HEPATIC CYTOCHROME P450 REDUCTASE-NULL MICE AS AN ANIMAL MODEL TO STUDY ELECTRON TRANSFER PATHWAYS IN CHOLESTEROL SYNTHESIS AND CYP2E1-MEDIATED DRUG METABOLISM [PDF]

, 2006
NADPH-cytochrome P450 reductase (CPR) is a flavoprotein containing both FAD and FMN and functions as the electron donor protein for several oxygenase enzymes found on the endoplasmic reticulum of eukaryotic cells, including cytochrome P450s involved in ...
Li, Li
core   +1 more source

Altered lipid subfraction profile and impaired antioxidant defense of high-density lipoprotein in Smith-Lemli-Opitz syndrome [PDF]

, 2020
Fülöp, Péter, Harangi, Mariann, Lőrincz, Hajnalka, Oláh, Anna, P. Szabó, Gabriella, Paragh, György, Seres, Ildikó, Somodi, Sándor   +7 more
core   +1 more source

Clinical Presentation and Diagnosis of Smith-Lemli-Opitz Syndrome: First Case Report from Sudan

Sudan Journal of Medical Sciences
Background: Smith-Lemli-Opitz syndrome (SLOS) is a congenital autosomal recessive disorder characterized by defective cholesterol metabolism, attributable to a deficiency of the enzyme 7-dehydrocholesterol reductase (DHCR7) caused by mutations in the ...
Rayan Khalid, Dalia Omer, Tarig Alsheikh, Imad Fadl-Elmula   +3 more
doaj   +1 more source