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Free Radical Biology and Medicine, 2016
7-Dehydrocholesterol reductase (DHCR7) serves as the penultimate enzyme in the Kandutsch-Russel pathway of cholesterol synthesis. When the function of DHCR7 is compromised its primary substrate, 7-dehydrocholesterol (7DHC), accumulates. The accumulation of 7DHC can be detrimental to many biological processes, as observed in the metabolic disorder Smith-
Phillip A Wages +2 more
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7-Dehydrocholesterol reductase (DHCR7) serves as the penultimate enzyme in the Kandutsch-Russel pathway of cholesterol synthesis. When the function of DHCR7 is compromised its primary substrate, 7-dehydrocholesterol (7DHC), accumulates. The accumulation of 7DHC can be detrimental to many biological processes, as observed in the metabolic disorder Smith-
Phillip A Wages +2 more
openaire +1 more source
Veterinary Microbiology
Pseudorabies virus (PRV) is an alpha-herpesvirus capable of infecting a range of animal species, particularly its natural host, pigs, resulting in substantial economic losses for the swine industry. Recent research has shed light on the significant role of cholesterol metabolism in the replication of various viruses.
Zicheng, Ma +8 more
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Pseudorabies virus (PRV) is an alpha-herpesvirus capable of infecting a range of animal species, particularly its natural host, pigs, resulting in substantial economic losses for the swine industry. Recent research has shed light on the significant role of cholesterol metabolism in the replication of various viruses.
Zicheng, Ma +8 more
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7‐Dehydrocholesterol reductase activity in developing rat brain
Journal of Neurochemistry, 1973N L, Banik, A N, Davison
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Current Cancer Drug Targets
Background: Cholesterol has been shown to be a potential risk factor for the occurrence and progression of breast cancer. This study aimed to investigate the regulation of DHCR7 in cholesterol synthesis and its role in Hedgehog (Hh) signaling pathway acti-vation, as well as its impact on the progression of triple-negative breast cancer (TNBC ...
Shuang, Qiu +7 more
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Background: Cholesterol has been shown to be a potential risk factor for the occurrence and progression of breast cancer. This study aimed to investigate the regulation of DHCR7 in cholesterol synthesis and its role in Hedgehog (Hh) signaling pathway acti-vation, as well as its impact on the progression of triple-negative breast cancer (TNBC ...
Shuang, Qiu +7 more
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Tetrahydroisoquinoline alkaloid derivatives Inhibit 7-Dehydrocholesterol reductase
Planta Medica, 2012A Horling +3 more
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