Results 121 to 130 of about 3,608 (158)

Electron transfer engineering of artificially designed cell factory for complete biosynthesis of steroids. [PDF]

Nat Commun
Chen Q, Wei W, Chao Z, Qi R, He J, Chen H, Wang K, Wang X, Rao Y, Zhou J.   +9 more
europepmc   +1 more source

DHCR7 as a Prognostic and Immunological Biomarker in Human Pan-Cancer: A Comprehensive Evaluation. [PDF]

Cancer Rep (Hoboken)
Wu X, Zheng W, Wang L, Lin D, Wu Z.
europepmc   +1 more source

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Rapid suppression of 7-dehydrocholesterol reductase activity in keratinocytes by vitamin D

Journal of Steroid Biochemistry and Molecular Biology, 2015
7-Dehydrocholesterol (7DHC) serves as the sterol substrate for both cholesterol and vitamin D3 (cholecalciferol) synthesis. The pivotal enzyme in these two pathways is 7-dehydrocholesterol reductase (DHCR7), which converts 7DHC to cholesterol. Treatment of adult human epidermal keratinocytes (HEKa) with 10μM cholecalciferol resulted in a rapid decrease
Ling Zou, Todd D Porter
exaly   +3 more sources

Structure and alternative splicing of the rat 7-dehydrocholesterol reductase gene

Biochimica Et Biophysica Acta Gene Regulatory Mechanisms, 2002
The enzyme 7-dehydrocholesterol reductase (Dhcr7) catalyzes the reduction of 7-dehydrocholesterol (DHC), the terminal reaction of the pathway of cholesterol biosynthesis. We report the isolation and characterization of the genomic DNA encoding rat Dhcr7 that contains nine exons and eight introns distributed over 15944 nucleotides (nts) and a consensus ...
Young-Ki Paik
exaly   +3 more sources

Biochemical and genetic aspects of 7-dehydrocholesterol reductase and Smith-Lemli-Opitz syndrome

Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids, 2000
In recent years, several inherited human disorders caused by defects in cholesterol biosynthesis have been identified. These are characterized by malformations, multiple congenital anomalies, mental and growth retardation and/or skeletal and skin abnormalities indicating a pivotal role of cholesterol in morphogenesis and embryonic development.
Hans Waterham, Ronald Wanders, R J Wanders   +2 more
exaly   +5 more sources

Antipsychotic Drugs Regulate Hedgehog Signaling by Modulation of 7-Dehydrocholesterol Reductase Levels

Molecular Pharmacology, 2010
Recently we identified GANT61, a small-molecule antagonist of Gli transcription factors, which are the final effectors of the mammalian Hedgehog (HH) signaling pathway. Here we describe a diamine substructure of GANT61 that carries the biological activity and show that this part of the molecule is structurally related to trans-1,4-bis(2 ...
Matthias Lauth, Per Svenningsson, Rune Toftgård   +2 more
exaly   +3 more sources

Phosphorylation regulates activity of 7-dehydrocholesterol reductase (DHCR7), a terminal enzyme of cholesterol synthesis

Journal of Steroid Biochemistry and Molecular Biology, 2017
Cholesterol is essential for survival, but too much or too little can cause disease. Thus, cholesterol levels must be kept within close margins. 7-dehydrocholesterol reductase (DHCR7) is a terminal enzyme of cholesterol synthesis, and is essential for embryonic development.
Anika Prabhu, Andrew Brown, Laura J Sharpe   +2 more
exaly   +3 more sources

Neonatal urinary steroids in Smith-Lemli-Opitz syndrome associated with 7-dehydrocholesterol reductase deficiency

Steroids, 1999
The biosynthetic abnormality in Smith-Lemli-Opitz syndrome (SLOS) is a deficiency of 7-dehydrocholesterol (7DHC) reductase, the enzyme responsible for catalyzing the final step in the Kandutsch-Russell pathway for cholesterol synthesis. Because the disposition of 7DHC and 8-dehydrocholesterol [8DHC; cholesta-5,8(9)-dien-3beta-ol] produced in this ...
Cedric H L Shackleton, E Roitman, Esther Roitman   +2 more
exaly   +3 more sources