Results 131 to 140 of about 3,608 (158)
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Biochemical and Biophysical Research Communications, 2004
Defects in cholesterol biosynthesis genes are recognized as a leading cause for holoprosencephaly (HPE). Previous reports suggest that mutations of human 7-dehydrocholesterol reductase (Dhcr7), which catalyzes the final step of cholesterol biosynthesis, may cause HPE [Clin. Genet. 53 (1998) 155]. To determine whether Dhcr7 mutations are involved in HPE
Chong Jai Kim +2 more
exaly +3 more sources
Defects in cholesterol biosynthesis genes are recognized as a leading cause for holoprosencephaly (HPE). Previous reports suggest that mutations of human 7-dehydrocholesterol reductase (Dhcr7), which catalyzes the final step of cholesterol biosynthesis, may cause HPE [Clin. Genet. 53 (1998) 155]. To determine whether Dhcr7 mutations are involved in HPE
Chong Jai Kim +2 more
exaly +3 more sources
Lipids and Lipid Metabolism, 1998
Plasma levels of the cholesterol precursor 7-dehydrocholesterol (7-DHC) were compared with activities of the rate-limiting enzyme in cholesterol biosynthesis, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase assayed in liver biopsies from patients undergoing cholecystectomy.
Bo Angelin, C Einarsson, E Reihnér
exaly +3 more sources
Plasma levels of the cholesterol precursor 7-dehydrocholesterol (7-DHC) were compared with activities of the rate-limiting enzyme in cholesterol biosynthesis, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase assayed in liver biopsies from patients undergoing cholecystectomy.
Bo Angelin, C Einarsson, E Reihnér
exaly +3 more sources
Antiviral Research, 2023
Recent studies have shown a close link between viral infections and cholesterol metabolism. Here, we reported that 7-dehydrocholesterol reductase (DHCR7), a terminal enzyme for catalyzing cholesterol synthesis in the Kandutsch-Russell pathway, is harnessed by enterovirus A71 (EV-A71) benefitting for its replication.
Huiqiang, Wang +7 more
openaire +2 more sources
Recent studies have shown a close link between viral infections and cholesterol metabolism. Here, we reported that 7-dehydrocholesterol reductase (DHCR7), a terminal enzyme for catalyzing cholesterol synthesis in the Kandutsch-Russell pathway, is harnessed by enterovirus A71 (EV-A71) benefitting for its replication.
Huiqiang, Wang +7 more
openaire +2 more sources
A New Class of Selective and Potent 7-Dehydrocholesterol Reductase Inhibitors
Journal of Medicinal Chemistry, 2012We prepared a number of N-phenethyltetrahydroisoquinolines structurally related to protoberberines. They were tested for activity against bacteria, fungi, and human leukemia HL-60 cells and also for inhibition of biosynthesis: ergosterol in yeasts and cholesterol in human cells.
Aline, Horling +4 more
openaire +2 more sources
Effects of Tween 80 on liver microsomal 7-dehydrocholesterol reductase
Biochemical and Biophysical Research Communications, 1978Abstract Enzymatic conversion of 7-dehydrocholesterol to cholesterol by liver microsomes was increased by addition of Tween 80. This increase was proportional to Tween 80 concentration, and reached its maximum of 250% of baseline activity after addition of 300 μg/ml of Tween 80.
M V, Srikantaiah, S, Assef, R J, Morin
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Teratology, 1996
Our aim is to verify the validity of a rat model proposed for Smith-Lemli-Opitz (SLO) syndrome, a developmental disorder characterized by a defect in 7-dehydrocholesterol-delta 7 (7DHC)-reductase and by facial dysmorphism close to the holoprosencephaly caused by the teratogen AY9944.
M, Kolf-Clauw +5 more
openaire +2 more sources
Our aim is to verify the validity of a rat model proposed for Smith-Lemli-Opitz (SLO) syndrome, a developmental disorder characterized by a defect in 7-dehydrocholesterol-delta 7 (7DHC)-reductase and by facial dysmorphism close to the holoprosencephaly caused by the teratogen AY9944.
M, Kolf-Clauw +5 more
openaire +2 more sources
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1965
Abstract 1. 1. The reduction of 7-dehydrocholesterol in cell-free rat-liver homogenates has been studied. The Michaelis constant (Km) was calculated from 11 experiments to be 1.14 · 10−3 with standard error ± 0.33 · 10−3. 2. 2. Three hypocholesterolemic agents inhibited 7-dehydrocholesterol conversion by liver homogenate.
R, Niemiro, R, Fumagalli
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Abstract 1. 1. The reduction of 7-dehydrocholesterol in cell-free rat-liver homogenates has been studied. The Michaelis constant (Km) was calculated from 11 experiments to be 1.14 · 10−3 with standard error ± 0.33 · 10−3. 2. 2. Three hypocholesterolemic agents inhibited 7-dehydrocholesterol conversion by liver homogenate.
R, Niemiro, R, Fumagalli
openaire +2 more sources
Naunyn-Schmiedeberg's Archives of Pharmacology, 1996
RPR 101821 (trans-2-[4-(benzoxazol-2-yl)-phenylmethoxy] amino cyclohexane hydrochloride) is a potent cholesterol-lowering agent in rodents and marmoset. The compound inhibited rat liver microsomal squalene synthase (IC50 = 1 nM) and 7-dehydrocholesterol (7DHC) reductase (IC50 = 1 microM; Lewis et al. 1995).
D, Amin +7 more
openaire +2 more sources
RPR 101821 (trans-2-[4-(benzoxazol-2-yl)-phenylmethoxy] amino cyclohexane hydrochloride) is a potent cholesterol-lowering agent in rodents and marmoset. The compound inhibited rat liver microsomal squalene synthase (IC50 = 1 nM) and 7-dehydrocholesterol (7DHC) reductase (IC50 = 1 microM; Lewis et al. 1995).
D, Amin +7 more
openaire +2 more sources
Molecular and Cellular Endocrinology, 2004
Postnatal Leydig cell development in rat involves an initial phase of proliferation of progenitor Leydig cells (PLCs) and subsequent differentiation of these cells into immature Leydig cells (ILCs) and adult Leydig cells (ALCs). With an objective to identify the molecular changes associated with Leydig cell differentiation, the mRNA population in PLCs ...
Anbalagan, M +2 more
openaire +2 more sources
Postnatal Leydig cell development in rat involves an initial phase of proliferation of progenitor Leydig cells (PLCs) and subsequent differentiation of these cells into immature Leydig cells (ILCs) and adult Leydig cells (ALCs). With an objective to identify the molecular changes associated with Leydig cell differentiation, the mRNA population in PLCs ...
Anbalagan, M +2 more
openaire +2 more sources
Biochemical Pharmacology, 1986
The effect of the piperazine derivative BM 15.766 (4-(2-[1-(4-chlorocinnamyl)piperazin-4-yl]ethyl]-benzoic acid) on the biosynthesis of sterols was investigated in adult rat hepatocytes in primary monolayer culture. The substance led to a dose-dependent reduction of cholesterol in the serum of various species of animals such as rat, dog and marmoset ...
J, Aufenanger +3 more
openaire +2 more sources
The effect of the piperazine derivative BM 15.766 (4-(2-[1-(4-chlorocinnamyl)piperazin-4-yl]ethyl]-benzoic acid) on the biosynthesis of sterols was investigated in adult rat hepatocytes in primary monolayer culture. The substance led to a dose-dependent reduction of cholesterol in the serum of various species of animals such as rat, dog and marmoset ...
J, Aufenanger +3 more
openaire +2 more sources