Results 91 to 100 of about 1,719 (107)

Phosphorylation regulates activity of 7-dehydrocholesterol reductase (DHCR7), a terminal enzyme of cholesterol synthesis

Journal of Steroid Biochemistry and Molecular Biology, 2017
Cholesterol is essential for survival, but too much or too little can cause disease. Thus, cholesterol levels must be kept within close margins. 7-dehydrocholesterol reductase (DHCR7) is a terminal enzyme of cholesterol synthesis, and is essential for embryonic development.
Anika Prabhu, Andrew Brown, Laura J Sharpe   +2 more
exaly   +3 more sources

The sterol-based transcriptional control of human 7-dehydrocholesterol reductase (DHCR7): Evidence of a cooperative regulatory program in cholesterol synthesis

Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids, 2014
The enzyme 7-dehydrocholesterol reductase (DHCR7) catalyzes the final step of cholesterol synthesis via the Kandutsch-Russell pathway, and is crucial in maintaining cellular cholesterol levels. Its absence leads to the devastating fetal developmental disorder Smith-Lemli-Opitz Syndrome (SLOS).
Anika Prabhu, Andrew Brown, Laura J Sharpe   +2 more
exaly   +3 more sources

Characterization and potential function of 7-dehydrocholesterol reductase (dhcr7) and lathosterol 5-desaturase (sc5d) in Cynoglossus semilaevis sexual size dimorphism

Gene, 2023
The typical sexual size dimorphism (SSD) phenomenon of Chinese tongue sole (Cynoglossus semilaevis) seriously restricts the sustainable development of the fishing industry. Previous transcriptome analysis has found a close relationship between the steroid biosynthesis and C. semilaevis SSD.
Jialin, Wang, Rui, Shi, Qian, Yang, Zhangfan, Chen, Jiacheng, Wang, Zhihong, Gong, Songlin, Chen, Na, Wang   +7 more
openaire   +2 more sources

Dose–Response Effects of 7-Dehydrocholesterol Reductase Inhibitors on Sterol Profiles and Vesicular Stomatitis Virus Replication

ACS Pharmacology and Translational Science, 2022
Thiago Genaro-Mattos, Hye-Young Kim, Ned Porter   +2 more
exaly  

Targeting 7-dehydrocholesterol reductase against EV-A71 replication by upregulating interferon response

Antiviral Research, 2023
Huiqiang Wang
exaly  

Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection

Immunity, 2020
Ruiyue Zhong, Xiaoyan Xu, Hualan Chen
exaly  

DHCR7: A vital enzyme switch between cholesterol and vitamin D production

Progress in Lipid Research, 2016
Anika Prabhu, Andrew Brown, Laura J Sharpe   +2 more
exaly  

7-Dehydrocholesterol reductase activity is independent of cytochrome P450 reductase

Journal of Steroid Biochemistry and Molecular Biology, 2011
Ling Zou, Todd D Porter
exaly  

Cholesterol-mediated Degradation of 7-Dehydrocholesterol Reductase Switches the Balance from Cholesterol to Vitamin D Synthesis

Journal of Biological Chemistry, 2016
Anika Prabhu, Andrew Brown, Laura J Sharpe   +2 more
exaly  

Increasing cholesterol synthesis in 7-dehydrosterol reductase (DHCR7) deficient mouse models through gene transfer

Journal of Steroid Biochemistry and Molecular Biology, 2010
Xavier Matabosch, Forbes D Porter, Christopher Wassif   +2 more
exaly