DHCR7: from sterol biosynthesis to oncogenic role in colorectal cancer [PDF]
PeerJObjective 7-Dehydrocholesterol reductase (DHCR7) is an enzyme that plays a crucial regulatory role in sterol biosynthesis and has been implicated in tumorigenesis and progression.
Chuan Zhou +8 more
doaj +6 more sources
Effect of DHCR7 on adipocyte differentiation in goats
Animal Biotechnology, 2023 Cholesterol is regarded as a signaling molecule in regulating the metabolism and function of fat cells, in which 7-Dehydrocholesterol reductase (DHCR7) is a key enzyme that catalyzes the conversion of 7-dehydrocholesterol to cholesterol, however, the ...
Youli Wang, Lin Yq
exaly +6 more sources
DHCR7 as a Prognostic and Immunological Biomarker in Human Pan‐Cancer: A Comprehensive Evaluation [PDF]
Cancer ReportsBackground The 7‐Dehydrocholesterol reductase (DHCR7), a critical enzyme catalyzing the final step of the cholesterol biosynthesis pathway, has gained attention for its potential role in tumorigenesis.
Xianghua Wu +4 more
doaj +4 more sources
Lactylation prognostic signature identifies DHCR7 as a modulator of chemoresistance and immunotherapy efficacy in bladder cancer [PDF]
Frontiers in ImmunologyBackgroundBladder cancer (BLCA), the 10th most common cancer worldwide, presents a worsening prognosis as the disease progresses. Reliable tools for predicting BLCA prognosis and treatment efficacy remain urgently needed.MethodsExpression profiles of ...
Yuanqiao Zhao +7 more
doaj +4 more sources
DHCR7 expression, function and estrogen-induced promoter histone modification changes in chicken granulosa cells of pre-hierarchical follicles [PDF]
Poultry ScienceFollicle selection is characterized by granulosa cell differentiation and progesterone production using cholesterol. 7-dehydrocholesterol reductase (DHCR7) is the rate-limiting enzyme in cholesterol synthesis.
Dandan Li +4 more
doaj +2 more sources
Cholesterol metabolism shapes immune low-response states in LUAD: a multi-omics cholesterol metabolism signature predicts immunotherapy benefit and identifies DHCR7 as a therapeutic target [PDF]
Frontiers in ImmunologyBackgroundCholesterol metabolism has been shown to affect the tumor microenvironment in various cancers, but its immunological role in lung adenocarcinoma (LUAD) remains unclear.MethodsWe integrated 1,682 LUAD samples (including 7 treatment-naïve bulk ...
Mingjun Du +6 more
doaj +2 more sources
Post-lanosterol inhibition profile based classification of commonly used prescription medications [PDF]
Translational PsychiatryCholesterol is an essential structural component of all cells, and the sterol biosynthetic pathway provides critical precursors for essential homeostatic molecules. Sterol biosynthesis can be disrupted by pathogenic variants in genes, as well as commonly
Keri A. Tallman +4 more
doaj +2 more sources
Metabolic reprogramming of cholesterol biosynthesis drives macrophage-mediated immune suppression in HPV-negative cervical adenocarcinoma [PDF]
Frontiers in ImmunologyBackgroundCervical adenocarcinoma is an increasingly common and aggressive subtype of cervical cancer with marked biological heterogeneity. Accumulating evidence suggests that HPV-positive and HPV-negative adenocarcinomas exhibit distinct immune ...
Jianing Zhang +3 more
doaj +2 more sources
Downmodulation of cholesterol biosynthetic network governs activation of the innate immune response to Japanese encephalitis virus infection [PDF]
Journal of VirologyViruses remodel metabolic processes and utilize host lipids for different stages of their life cycle. Our earlier studies have shown that the flavivirus Japanese encephalitis virus (JEV) downmodulates several key proteins involved in sterol and lipid ...
Sakshi Khera +3 more
doaj +2 more sources
Regulatory Mechanism of DHCR7 Gene Expression by Estrogen in Chicken Granulosa Cells of Pre-Hierarchical Follicles [PDF]
BiomoleculesThe difference in chicken egg production is closely related to the efficiency of follicle selection, which is marked by granulosa cell differentiation and progesterone production with cholesterol as the substrate.
Dandan Li +5 more
doaj +2 more sources