Results 21 to 30 of about 3,939 (151)

ESRP1 exerts anti-tumor role by promoting ferroptosis in diffuse-type gastric cancer [PDF]

Journal of Experimental & Clinical Cancer Research
Diffuse-type gastric cancer (DGC) accounts for approximately one-third of gastric cancer cases, but it is clinically more aggressive and associated with poorer survival prognosis compared to intestinal-type gastric cancer (IGC).
Kang Xu, Hao Chen, Xingyu Zhu, Han Li, Xinyu Liu, Yaodong Sang, Xiaohan Wang, Xiaoling Cui, Baoshan Cai, Liang Shang, Wei Chong, Leping Li   +11 more
doaj   +2 more sources

Smith‐Lemli‐Opitz Syndrome and the DHCR7 Gene [PDF]

Annals of Human Genetics, 2003
SummarySmith‐Lemli‐Opitz syndrome, a severe developmental disorder associated with multiple congenital anomalies, is caused by a defect of cholesterol biosynthesis. Low cholesterol and high concentrations of its direct precursor, 7‐dehydrocholesterol, in plasma and tissues are the diagnostic biochemical hallmarks of the syndrome.
Jira, P.E., Waterham, H.R., Wanders, R.J., Smeitink, J.A.M., Sengers, R.C.A., Wevers, R.A.   +5 more
openaire   +4 more sources

ANKRD55 and DHCR7 are novel multiple sclerosis risk loci [PDF]

Genes & Immunity, 2011
Multiple sclerosis (MS) shares some risk genes with other disorders hallmarked by an autoimmune pathogenesis, most notably IL2RA and CLEC16A. We analyzed 10 single-nucleotide polymorphisms (SNPs) in nine risk genes, which recently emerged from a series of non-MS genome-wide association studies (GWAS), in a Spanish cohort comprising 2895 MS patients and
I, Alloza, D, Otaegui, A Lopez, de Lapuente, A, Antigüedad, J, Varadé, C, Núñez, R, Arroyo, E, Urcelay, O, Fernandez, L, Leyva, M, Fedetz, G, Izquierdo, M, Lucas, B, Oliver-Martos, A, Alcina, A, Saiz, Y, Blanco, M, Comabella, X, Montalban, J, Olascoaga, F, Matesanz, K, Vandenbroeck   +21 more
openaire   +2 more sources

Generation and validation of a conditional knockout mouse model for the study of the Smith-Lemli-Opitz syndrome

Journal of Lipid Research, 2021
Smith-Lemli-Opitz Syndrome (SLOS) is a developmental disorder (OMIM #270400) caused by autosomal recessive mutations in the Dhcr7 gene, which encodes the enzyme 3β-hydroxysterol-Δ7 reductase.
Babunageswararao Kanuri, Vincent Fong, Sithara Raju Ponny, Keri A. Tallman, Sriganesh Ramachandra Rao, Ned Porter, Steven J. Fliesler, Shailendra B. Patel   +7 more
doaj   +1 more source

High DHCR7 Expression Predicts Poor Prognosis for Cervical Cancer

Computational and Mathematical Methods in Medicine, 2022
DHCR7 is a rate-limiting enzyme in cholesterol synthesis. The expression pattern and prognostic value of DHCR7 in cervical cancer are unknown. We investigated the relationship between DHCR7 expression and clinicopathological features of cervical cancer patients. The dataset was acquired from TCGA database. The Wilcoxon rank sum test was used to explore
Jing Zou, Sha Liu, Jian Long, Bingbing Yan   +3 more
openaire   +2 more sources

Trazodone effects on developing brain

Translational Psychiatry, 2021
Trazodone (TRZ) is a commonly prescribed antidepressant with significant off-label use for insomnia. A recent drug screening revealed that TRZ interferes with sterol biosynthesis, causing elevated levels of sterol precursor 7-dehydrocholesterol (7-DHC ...
Zeljka Korade, Luke B. Allen, Allison Anderson, Keri A. Tallman, Thiago C. Genaro-Mattos, Ned A. Porter, Karoly Mirnics   +6 more
doaj   +1 more source

7-Dehydrocholesterol-derived oxysterols cause neurogenic defects in Smith-Lemli-Opitz syndrome

eLife, 2022
Defective 3β-hydroxysterol-Δ7 -reductase (DHCR7) in the developmental disorder, Smith-Lemli-Opitz syndrome (SLOS), results in a deficiency in cholesterol and accumulation of its precursor, 7-dehydrocholesterol (7-DHC).
Hideaki Tomita, Kelly M Hines, Josi M Herron, Amy Li, David W Baggett, Libin Xu   +5 more
doaj   +1 more source

Association of Vitamin D Anabolism-Related Gene Polymorphisms and Susceptibility to Uterine Leiomyomas

Frontiers in Genetics, 2022
Background: Uterine leiomyomas (ULs) is the most common gynecological benign tumor in women. Our previous study showed that the phenomenon of vitamin D deficiency existed in patients with ULs.
Shangdan Xie, Mengying Jiang, Hejing Liu, Fang Xue, Xin Chen, Xueqiong Zhu   +5 more
doaj   +1 more source

Integrated multi-dimensional analysis highlights DHCR7 mutations involving in cholesterol biosynthesis and contributing therapy of gastric cancer

Journal of Experimental & Clinical Cancer Research, 2023
Background Genetic background plays an important role in the occurrence and development of gastric cancer (GC). With the application of genome-wide association study (GWAS), an increasing number of tumor susceptibility genes in gastric cancer have been ...
Yuqi Chen, Wenying Yan, Kexi Yang, Yiting Qian, Yanjun Chen, Ruoqin Wang, Jinghan Zhu, Yuxin He, Hongya Wu, Guangbo Zhang, Tongguo Shi, Weichang Chen   +11 more
doaj   +1 more source

Engineering of Saccharomyces cerevisiae for 24-Methylene-Cholesterol Production

Biomolecules, 2021
24-Methylene-cholesterol is a necessary substrate for the biosynthesis of physalin and withanolide, which show promising anticancer activities. It is difficult and costly to prepare 24-methylene-cholesterol via total chemical synthesis. In this study, we
Jiao Yang, Changfu Li, Yansheng Zhang
doaj   +1 more source