Results 1 to 10 of about 1,719 (107)

Selective ability of rat 7-Dehydrocholesterol reductase (DHCR7) to act on some 7-Dehydrocholesterol metabolites but not on lumisterol metabolites [PDF]

Journal of Steroid Biochemistry and Molecular Biology, 2021
7-Dehydrocholesterol reductase (DHCR7) catalyses the final step of cholesterol biosynthesis in the Kandutsch-Russel pathway, the reduction of 7-dehydrocholesterol (7DHC) to cholesterol. 7DHC can be acted on by a range of other enzymes including CYP27A1 and CYP11A1, as well as by UVB radiation, producing a number of derivatives including hydroxy ...
, Robert Tuckey, Edith Tang
exaly   +4 more sources

Downmodulation of cholesterol biosynthetic network governs activation of the innate immune response to Japanese encephalitis virus infection [PDF]

Journal of Virology
Viruses remodel metabolic processes and utilize host lipids for different stages of their life cycle. Our earlier studies have shown that the flavivirus Japanese encephalitis virus (JEV) downmodulates several key proteins involved in sterol and lipid ...
Sakshi Khera, Kiran Bala Sharma, Yashwant Kumar, Manjula Kalia   +3 more
doaj   +2 more sources

DHCR7: from sterol biosynthesis to oncogenic role in colorectal cancer [PDF]

PeerJ
Objective 7-Dehydrocholesterol reductase (DHCR7) is an enzyme that plays a crucial regulatory role in sterol biosynthesis and has been implicated in tumorigenesis and progression.
Chuan Zhou, Jia Wang, Han He, Chao Wang, YunFeng Zhang, Wenbo Zhang, Bin Wei, Mingxu Da, Minghui Pang   +8 more
doaj   +3 more sources

Hydroxyzine Effects on Post-Lanosterol Biosynthesis in Smith–Lemli–Opitz Syndrome (SLOS) Models [PDF]

Biomolecules
Smith–Lemli–Opitz syndrome (SLOS) is a developmental disability arising from bi-allelic pathogenic variants in the 7-dehydrocholestrol reductase (DHCR7) enzyme and the accumulation of 7-dehydrocholesterol (7-DHC).
Zeljka Korade, Allison C. Anderson, Marta Balog, Keri A. Tallman, Ned A. Porter, Karoly Mirnics   +5 more
doaj   +2 more sources

Maternal cariprazine exposure effects on lactating offspring sterol biosynthesis [PDF]

Translational Psychiatry
In the developing brain cholesterol is synthesized by both neurons and glia, and sterol biosynthesis peaks in early postnatal life. Genetic disruptions of sterol biosynthesis genes lead to complex intellectual and developmental disabilities. In addition,
Allison C. Anderson, Kanika Sharma, Željka Korade, Károly Mirnics   +3 more
doaj   +2 more sources

A case of Smith-Lemli-Opitz syndrome diagnosed by identification of mutations in the 7-dehydrocholesterol reductase (DHCR7) gene

Korean Journal of Pediatrics, 2008
Smith-Lemli-Opitz syndrome (SLOS) is a rare, autosomal recessive disease caused by an inborn error in cholesterol synthesis. Patients with this disease suffer from multiple malformations due to reduced activity of 7-dehydrocholesterol reductase (DHCR7), which increases 7-dehydrocholesterol (7DHC) and 8-dehydrocholesterol (8DHC) concentrations and ...
Han-Wook Yoo, Jung Min Ko, Gu-Hwan Kim
exaly   +2 more sources

Regulatory Mechanism of DHCR7 Gene Expression by Estrogen in Chicken Granulosa Cells of Pre-Hierarchical Follicles [PDF]

Biomolecules
The difference in chicken egg production is closely related to the efficiency of follicle selection, which is marked by granulosa cell differentiation and progesterone production with cholesterol as the substrate.
Dandan Li, Longxiao Hu, Qingqing Wei, Li Kang, Yi Sun, Yunliang Jiang   +5 more
doaj   +2 more sources

DHCR7 expression, function and estrogen-induced promoter histone modification changes in chicken granulosa cells of pre-hierarchical follicles [PDF]

Poultry Science
Follicle selection is characterized by granulosa cell differentiation and progesterone production using cholesterol. 7-dehydrocholesterol reductase (DHCR7) is the rate-limiting enzyme in cholesterol synthesis.
Dandan Li, Qingqing Wei, Li Kang, Yi Sun, Yunliang Jiang   +4 more
doaj   +2 more sources

DHCR7 as a Prognostic and Immunological Biomarker in Human Pan‐Cancer: A Comprehensive Evaluation [PDF]

Cancer Reports
Background The 7‐Dehydrocholesterol reductase (DHCR7), a critical enzyme catalyzing the final step of the cholesterol biosynthesis pathway, has gained attention for its potential role in tumorigenesis.
Xianghua Wu, Weiwei Zheng, Li Wang, Dan Lin, Zhaoxing Wu   +4 more
doaj   +2 more sources

Use of cholic acid in Smith-Lemli-Opitz syndrome (SLOS): real-world patient outcomes [PDF]

Orphanet Journal of Rare Diseases
Background Smith-Lemli-Opitz Syndrome (SLOS) is an autosomal recessive disorder of cholesterol biosynthesis caused by biallelic pathogenic variants in DHCR7, which encodes the enzyme 7-dehydrocholesterol reductase (DHCR7).
Edwin Ferren, Paul R. Hillman, Amy Kritzer, Joseph Ray, Alvaro Serrano, Hope Northrup, Paige Roberts, Rana Dutta, Tiziano Pramparo, Pamela Vig, Robert D. Steiner   +10 more
doaj   +2 more sources