DHCR7 inhibition ameliorates MetALD and HCC in mice and human 3D liver spheroids [PDF]
JHEP ReportsBackground & Aims: Metabolic dysfunction and alcohol-associated liver disease (MetALD) results in the development of liver steatosis, inflammation, fibrosis, and hepatocellular carcinoma (HCC).
Gen Yamamoto +10 more
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NSC777201 exhibits anticancer activity against colorectal cancer cells by inducing multiple types of cell death [PDF]
Cancer Cell InternationalBackground Colorectal cancer (CRC) ranks as the third most prevalent cancer globally, necessitating the development of novel therapeutic strategies. NSC777201, a multi-targeted anticancer agent, has demonstrated efficacy in various cancers, including ...
Hsin-Hsuan Ho +3 more
doaj +2 more sources
Molecular Genetics and Metabolism Reports, 2015 Smith Lemli Opitz syndrome (SLOS) is an inherited malformation and mental retardation metabolic disorder with no cure. Mutations in the last enzyme of the cholesterol biosynthetic pathway, 7-dehydrocholesterol reductase (DHCR7), lead to cholesterol ...
Cedric H L Shackleton, Gordon Watson
exaly +3 more sources
Electron transfer engineering of artificially designed cell factory for complete biosynthesis of steroids [PDF]
Nature CommunicationsBiosynthesis of steroids by artificially designed cell factories often involves numerous nicotinamide adenine dinucleotide phosphate (NADPH)-dependent enzymes that mediate electron transfer reactions.
Qihang Chen +9 more
doaj +2 more sources
Cholesterol overload in macrophages drives metabolic dysfunction-associated steatohepatitis via inhibiting 7-dehydrocholesterol reductase in mice [PDF]
Journal of Translational MedicineBackground Dietary cholesterol promotes metabolic dysfunction-associated steatohepatitis (MASH), with hepatic macrophages central to disease pathology. However, the mechanisms by which cholesterol-loaded macrophages influence MASH remain unclear. Methods
Xiaoxiao Li +7 more
doaj +2 more sources
Homozygous DHCR7 p.Val330Met Variant Associated with Mild Non-Syndromic Intellectual Disability and Elevated Serum 7-Dehydrocholesterol Levels in Two Siblings [PDF]
GenesAndreas Janecke, , Thomas Zöggeler
exaly +2 more sources
7-Dehydrocholesterol-derived oxysterols cause neurogenic defects in Smith-Lemli-Opitz syndrome
eLife, 2022 Defective 3β-hydroxysterol-Δ7 -reductase (DHCR7) in the developmental disorder, Smith-Lemli-Opitz syndrome (SLOS), results in a deficiency in cholesterol and accumulation of its precursor, 7-dehydrocholesterol (7-DHC).
Hideaki Tomita +5 more
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Effects of Psychotropic Medication on Somatic Sterol Biosynthesis of Adult Mice
Biomolecules, 2022 Polypharmacy is commonly used to treat psychiatric disorders. These combinations often include drugs with sterol biosynthesis inhibiting side effects, including the antipsychotic aripiprazole (ARI), and antidepressant trazodone (TRZ).
Marta Balog +4 more
doaj +1 more source
, 2022 Abstract Background: DHCR7, a switch between cholesterol and vitamin D synthesis that plays a pivotal role in tumorigenesis, is a promising therapeutic target in oncology. Despite increasing strong support for its importance, there is no pan-cancer analysis across multiple databases that can be available for in-depth data mining of the gene ...
Wumin Dai +4 more
openaire +1 more source
Smith-Lemli-Opitz syndrome: Bosnian and Herzegovinian experience
Balkan Journal of Medical Genetics, 2021 The aim of this paper is to present a patient with the Smith-Lemli-Opitz syndrome (SLOS), with an overview of the modality of diagnosis, and the treatment of the patient. Exome analysis showed two variants in exon 6 of the 7-dehydrocholesterol reductase (
Begic N, Begic Z, Begic E
doaj +1 more source