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Methodological considerations and factors affecting 8-hydroxy-2′-deoxyguanosine analysis
Free Radical Research, 1998Oxidative stress is related to a number of diseases due to the formation of reactive oxygen species (ROS). There are also several substances found in the occupational environment or as life style related situations that generates ROS. A stable biomarker for oxidative stress on DNA is 8-hydroxy-2'-deoxyguanosine (8-OH-dG).
L, Möller, T, Hofer, M, Zeisig
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Pattern recognition of 8-hydroxy-2′-deoxyguanosine in biological fluids
Analytical and Bioanalytical Chemistry, 20178-Hydroxy-2'-deoxyguanosine (8-OHdG), a product of oxidative DNA damage, which has been used as a sensitive and reliable marker of oxidative stress and carcinogenesis, is found in high levels in biological fluids of leukemia patients. A reliable screening method based on pattern recognition of 8-OHdG using stochastic sensors designed with graphene ...
Raluca-Ioana, Stefan-van Staden +6 more
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Expression of 8-hydroxy-2′-deoxyguanosine in gastric carcinomas
Journal of Nanjing Medical University, 2007Abstract Objective Reactive oxygen species may be involved in the progression of gastric carcinomas. To clarify whether the pathology of gastric carcinoma are related to oxidative DNA damage, the expression of 8-hydroxy-2′-deoxyguanosine (8-OHdG) was examined in 30 patients with gastric carcinomas.
Xiaoyu Chen, Jun Du, Luo Gu
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Increased Serum Levels of 8-Hydroxy-2′-Deoxyguanosine in Clinical Depression
Psychosomatic Medicine, 2006We sought to understand the pathophysiological effects of depression by examining group differences in serum levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), a biomarker of oxidative damage.Our sample consisted of 169 participants. Eight-four of these participants met diagnostic criteria for clinical depression.
Michael J, Forlenza, Gregory E, Miller
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Quantitative immunoanalysis of promutagenic 8-hydroxy-2'-deoxyguanosine in oxidized DNA
Carcinogenesis, 1994The modified DNA base 8-hydroxyguanine has been implicated in spontaneous mutagenesis, carcinogenesis and cellular aging. Polyclonal antibodies specific for the 8-hydroxy-2'-deoxyguanosine moiety in oxidized DNA were used for sensitive detection and quantitation of this biomarker of oxidative damage to cellular DNA.
J, Musarrat, A A, Wani
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Increased urinary 8‐hydroxy‐2′‐deoxyguanosine excretion after ileal neobladder replacement
BJU International, 2003OBJECTIVES To examine whether orthotopic neobladder replacement using either ileum or colon segments results in increased oxidative stress, by measuring urinary 8‐hydroxy‐2′‐deoxyguanosine (8‐OHdG), one of the most commonly used markers for evaluating oxidative DNA damage.
H, Miyake +4 more
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Journal of the American Chemical Society, 2018
Natural selection over billions of years has developed highly effective in vivo signal transduction that is often governed by a series of competitive multiple mechanisms. Several artificial signal transduction pathways have inspired numerous biosensing systems, but most of these are driven by a single mechanism.
Yanqin Lv +6 more
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Natural selection over billions of years has developed highly effective in vivo signal transduction that is often governed by a series of competitive multiple mechanisms. Several artificial signal transduction pathways have inspired numerous biosensing systems, but most of these are driven by a single mechanism.
Yanqin Lv +6 more
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Evidence of oligonucleotides containing 8-hydroxy-2′-deoxyguanosine in human urine
Free Radical Biology and Medicine, 2007The product of oxidative damage to DNA, 8-hydroxy-2'-deoxyguanosine (8-OHdG), when detected in urine, is considered to be a global, noninvasive biomarker of in vivo oxidative DNA damage. In this paper we describe a novel approach to confirm the presence of oligonucleotides containing 8-OHdG in human urine.
Parul R, Patel +3 more
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Metformin decreases serum 8-hydroxy-2′-deoxyguanosine levels in polycystic ovary syndrome
Fertility and Sterility, 2013To learn whether metformin treatment affects oxidative stress as measured by serum concentrations of 8-hydroxy-2'-deoxyguanosine (8-OHdG).Double-blind, randomized, placebo-controlled trial.University outpatient clinic.The study cohort consisted of 50 obese women (body mass index [BMI] ≥ 27 kg/m(2)) and 60 nonobese patients (BMI
Sova Henri +3 more
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8-Hydroxy-2'-Deoxyguanosine and Lipid Peroxidation in Patients With Heart Failure
Revista Española de Cardiología (English Edition), 2006Heart failure is associated with increased free radical production, which leads to a state of oxidative stress. Known markers of oxidative stress include 8-hydroxy-2'-deoxyguanosine, which reflects oxidative damage to DNA, and lipid peroxidation, which can be used to quantify damage to lipid-rich structures.
Miguel, Rivera +14 more
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