Results 201 to 210 of about 23,028 (215)

Longitudinal study of urinary 8-hydroxy-2′-deoxyguanosine excretion in healthy adults

Free Radical Research, 2001
Numerous studies have investigated the urinary excretion of 8-hydroxy-2'-deoxyguanosine (8-OHdG) as a biomarker for the assessment of oxidative DNA damage in humans. In this study, we performed six consecutive series of measurement of urinary levels of 8-OHdG in 68 healthy probands, in order to provide information on the intra- and inter-individual ...
A, Pilger, D, Germadnik, K, Riedel, I, Meger-Kossien, G, Scherer, H W, Rüdiger   +5 more
openaire   +2 more sources

Age-dependent Expression of 8-hydroxy-2'-deoxyguanosine in Human Pituitary Gland

The Histochemical Journal, 2001
A major oxidative product, 8-hydroxy-2'-deoxyguanosine (8-OHdG) is involved in ageing, carcinogenesis, and different diseases. The expression of 8-OHdG in the human pituitary gland was investigated immunohistochemically using specimens from individuals aged 19-88 years.
T, Kondo, T, Ohshima, Y, Ishida
openaire   +2 more sources

The role of 8-hydroxy-2′-deoxyguanosine in rifamycin-induced DNA damage

Free Radical Biology and Medicine, 1995
The effect of rifamycin SV on the formation of 8-hydroxy-2'-deoxyguanosine (8-0HdG) has been investigated in vitro and in vivo. Oxidative modification of 2'-deoxyguanosine has been measured as an indication of DNA damage using high-performance liquid chromatography with electrochemical detection.
P, Muñiz, V, Valls, C, Perez-Broseta, A, Iradi, J V, Climent, M R, Oliva, G T, Sáez   +6 more
openaire   +2 more sources

Mapping histological levels of 8-hydroxy-2′-deoxyguanosine in female reproductive organs

Journal of Molecular Histology, 2012
Oxidative stress is associated with many disease states including gynecologic disease. This process can damage lipids, proteins and DNA. The present study highlights the role of oxidative stress induced DNA damage as measured by 8-hydroxy-2-deoxyguanosine in development of benign gynecological conditions (BGC).
Luiz Fernando Pina, de Carvalho, Mauricio Simões, Abrão, Charles, Biscotti, Rakesh, Sharma, Ashok, Agarwal, Tommaso, Falcone   +5 more
openaire   +2 more sources

8-Hydroxy-2'-deoxyguanosine is a prognostic mediator for cardiac event.

European journal of clinical investigation, 2011
DNA in the nucleus is one of the major targets of reactive oxygen species (ROS), and oxidative DNA damage has been implicated in the pathogenesis of chronic heart failure. 8-Hydroxy-2'-deoxyguanosine (8-OHdG) is produced from deoxyguanosine in DNA by ROS.
Satoshi, Suzuki, Tetsuro, Shishido, Mitsunori, Ishino, Shigehiko, Katoh, Toshiki, Sasaki, Satoshi, Nishiyama, Takehiko, Miyashita, Takuya, Miyamoto, Joji, Nitobe, Tetsu, Watanabe, Yasuchika, Takeishi, Isao, Kubota   +11 more
openaire   +3 more sources

A label-free electrochemical aptasensor for 8-hydroxy-2′-deoxyguanosine detection

Journal of Electroanalytical Chemistry, 2015
Abstract A label-free electrochemical aptasensor for the determination of 8-hydroxy-2′-deoxyguanosine (8-OH-dG) was described here. This method was based on the conformational change of 8-OH-dG-aptamer (Apt) in the presence of 8-OH-dG. The G-rich Apt was self-assembled on the surface of gold electrode by Au-S bond.
Shan-Shan Shi, Li-Ping Jia, Rong-Na Ma, Wen-Li Jia, Huai-Sheng Wang   +4 more
openaire   +1 more source

Recent developments in analytical methodology for 8-hydroxy-2′-deoxyguanosine and related compounds

Journal of Chromatography B, 2005
When biomolecules such as proteins, lipids, and DNA are subjected to oxidative attack by free radicals or other reactive species, a number of measurable biomarkers may be produced. The study of oxidative DNA damage is valuable in research concerning cancer and aging.
Michael C, Peoples, H Thomas, Karnes
openaire   +2 more sources

Significance of 8‐hydroxy‐2′‐deoxyguanosine levels in patients with chronic renal failure

Nephrology, 2003
SUMMARY:   The aim of this study was to determine the significance of 8‐hydroxy‐2′‐deoxyguanosine (8‐OHdG), which is known as a marker of oxidative stress in vivo, in patients with chronic renal failure (CRF). Fifty‐one non‐dialysed CRF patients (29 men and 22 women; mean ± SD age, 57.8 ± 12.8 years) who were under dietary therapy for at least 6 months
Shigeru, Akagi, Yoshio, Nagake, Junko, Kasahara, Ai, Sarai, Takashi, Kihara, Hisanori, Morimoto, Ai, Yano, Kazushi, Nakao, Kiyohito, Nanba, Haruo, Ichikawa, Hirofumi, Makino   +10 more
openaire   +2 more sources

[Urinary 8-hydroxy-2'-deoxyguanosine: a biomarker of environmental oxidative stress?].

Annales de biologie clinique, 2008
The oxidative stress plays an important role in certain pathologies, notably in carcinogenesis. Indeed, reactive oxygen species (ROS) can induce a variety of damage to DNA, including oxidized bases which will then be repaired and eliminated in urine.
L, Sajous, A, Botta, I, Sari-Minodier
openaire   +1 more source

[Urinary 8-OHdG (8-hydroxy-2'-deoxyguanosine)].

Nihon rinsho. Japanese journal of clinical medicine, 2005
Hirotomo, Ochi, Masayo, Iida, Kazuo, Sakai   +2 more
openaire   +1 more source