Transcriptional Regulator TonEBP Mediates Oxidative Damages in Ischemic Kidney Injury [PDF]
, 2019 TonEBP (tonicity-responsive enhancer binding protein) is a transcriptional regulator whose expression is elevated in response to various forms of stress including hyperglycemia, inflammation, and hypoxia.
Choi, Soo Youn +10 more
core +1 more source
DNA oxidation after exercise: a systematic review and meta-analysis
Frontiers in Physiology, 2023 Purpose: 8-Hydroxy-2′-deoxyguanosine (8-OHdG) is a byproduct of DNA oxidation resulting from free radical attacks. Paradoxically, treatment with 8-OHdG accelerates tissue healing.
Mengxin Ye +11 more
doaj +1 more source
Accumulation of promutagenic DNA adducts in the mouse distal colon after consumption of heme does not induce colonic neoplasms in the western diet model of spontaneous colorectal cancer [PDF]
, 2013 Author version made available in accordance with Publisher copyright policy.Scope: Red meat is considered a risk factor for colorectal cancer (CRC). Heme is considered to promote colonic hyperproliferation and cell damage. Resistant starch (RS) is a food
Conlon, Michael A +5 more
core +1 more source
Environmental Chemistry and EcotoxicologyThe association between childhood metal exposure and oxidative stress levels is of paramount importance, as children are a susceptible group to metal toxicity and elevated oxidative damage has been linked to a variety of diseases.
Mei Liu +5 more
doaj +1 more source
Traffic-related exposures and biomarkers of systemic inflammation, endothelial activation and oxidative stress: a panel study in the US trucking industry [PDF]
, 2013 Background: Experimental evidence suggests that inhaled particles from vehicle exhaust have systemic effects on inflammation, endothelial activation and oxidative stress.
Cavallari, Jennifer M +7 more
core +1 more source
Highly Sensitive Electrochemical Sensor for the Determination of 8-Hydroxy-2 \u27-deoxyguanosine Incorporating SWCNTs-Nafion Composite Film [PDF]
, 2015 8-Hydroxy-2\u27-deoxyguanosine (8-OHdG) is a typical biomarker of oxidative DNA damage and has attracted much attention in recent years since the level of 8-OHdG in body fluids is typically associated with various diseases.
Gao, Qiang +5 more
core +2 more sources
Urinary 8-Hydroxy-2-deoxyguanosine and Cognitive Function in Puerto Rican Adults [PDF]
American Journal of Epidemiology, 2010 DNA oxidative stress has been suggested as an important pathogenic mechanism in cognitive impairment and dementia. With baseline data collected from 2004 to 2008, the authors examined whether urinary 8-hydroxy-2-deoxyguanosine (8-OHdG), a biomarker of global DNA oxidation, was associated with cognitive function in a sample of 1,003 Puerto Rican adults,
Xiang, Gao +6 more
openaire +2 more sources
The effects of graded levels of calorie restriction : II. Impact of short term calorie and protein restriction on circulating hormone levels, glucose homeostasis and oxidative stress in male C57BL/6 mice [PDF]
, 2015 This work was supported by BBSRC BB009953/1 awarded to JRS and SEM. PK and CD were funded by the Erasmus exchange programme. JRS, SEM, DD, CG, LC, JJDH, YW, DELP, DL and AD are members of the BBSRC China Partnership Award, BB/J020028/1.Peer ...
Chen, Luonan +12 more
core +2 more sources
Nickel(II)-catalysed oxidative guanine and DNA damage beyond 8-oxoguanine [PDF]
, 2007 Oxidative DNA damage is one of the most important and most studied mechanisms of disease. It has been associated with a range of terminal diseases such as cancer, heart disease, hepatitis, and HIV, as well as with a variety of everyday ailments.
Kelly, Michele C. +3 more
core +1 more source
Advanced Functional Materials, EarlyView.A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo +7 more
wiley +1 more source