Results 51 to 60 of about 23,028 (215)

Evaluation of urinary hydrogen peroxide as an oxidative stress biomarker in a healthy Japanese population [PDF]

, 2013
The usefulness of urinary hydrogen peroxide (H2O2) as an oxidative stress biomarker was evaluated in 766 healthy Japanese. The mean level of urinary concentrations of H2O2 was 5.66 +/- 8.27 mu mol/g creatinine, and was significantly higher in females ...
Almar M, Bae JM, Banerjee D, Barbieri E, Chandramathi S, Cooke MS, Cooke MS, D. H. Wang, Devries MC, Drews G, Evans MD, Gomez-Cabrera MC, Greenblatt DJ, H. Takahashi, Halliwell B, Hiramoto K, J. Yoshida, Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases, K. Inoue, K. Ogino, Lesgards JF, Long LH, Long LH, M. Kubo, Martin CG, McCommis KS, Mesaros C, Morillas-Ruiz J, Musicki B, Møller P, N. Sakano, Okamura K, Orhan H, Ostojić S, Polidori MC, Rahimi R, Ristow M, S. Kanbara, Saito S, Sies H, Song MF, Wang X, Y. Akazawa, Y. Sato, Yeligar SM   +44 more
core   +1 more source

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

Advanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang, Shuang Feng, Jie Luo, Kaige Xu, Junfeng Guo, Xingyue Zhang, Mengxue Yuan, Qiang Luo, Yu Huang, Chaoqiang Fan, Kibret Mequanint, Donghui Zhu, Malcolm Xing, Shiming Yang   +13 more
wiley   +1 more source

Development of assays for biomarkers of oxidative damage to assess the efficacy of fruit-derived antioxidants : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University [PDF]

, 2003
The diet is a very important part of maintaining a healthy lifestyle. Increased consumption of fruits and vegetables is one practice postulated to decrease the incidence of diseases such as cancer, cardiovascular disease and other disorders.
Barnett, Laura Evelyn
core  

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

Effects of occupational exposure to Radioactive beams on oxidative DNA damage in Radiography staff in Isfahan\'s public hospitals

Salāmat-i kār-i Īrān, 2020
Background and aims: Although ionizing radiation is very effective in medical science to diagnose and treat diseases, it can also be the cause of cancer. Ionizing radiation produces free radicals that leading to oxidative DNA damage. 8-Hydroxy-2chr('39')-
karim ebrahimpour, azam salehi, farhad Forouharmajd   +2 more
doaj  

Determination of 8-hydroxy-2'deoxyguanosine in Urine Using HPLC With Electrochemical Detection [PDF]

Archives of Industrial Hygiene and Toxicology, 2008
Determination of 8-hydroxy-2'deoxyguanosine in Urine Using HPLC With Electrochemical DetectionEndogenous cell metabolism and different chemicals, drugs, ionising radiation, solar light, cigarette smoking, and air pollution can induce oxidative damage to DNA.
Peraica, Maja, Domijan, Ana-Marija
openaire   +2 more sources

Oxidative stress markers are elevated in exhaled breath condensate of workers exposed to nanoparticles during iron oxide pigment production [PDF]

, 2016
PubMed ID: 26828137Markers of oxidative stress and inflammation were analysed in the exhaled breath condensate (EBC) and urine samples of 14 workers (mean age 43  ±  7 years) exposed to iron oxide aerosol for an average of 10  ±  4 years and 14 controls (
Barošová, Hana, Běláček, Jaroslav, Fenclová, Zdenka, Kačer, Petr, Komarc, Martin, Kukutschová, Jana, Navrátil, Tomáš, Pelcl, Tomáš, Pelclová, Daniela, Schwarz, Jaroslav, Syslová, Kamila, Turci, Francesco, Vlčková, Štěpánka, Zakharov, Sergey, Zíková, Naděžda, Ždímal, Vladimír   +15 more
core   +1 more source

Mammalian Proteome Profiling Reveals Readers and Antireaders of Strand‐Symmetric and ‐Asymmetric 5‐Hydroxymethylcytosine‐Modifications in DNA

Advanced Science, EarlyView.
We investigate by proteomics studies how strand‐symmetric and ‐asymmetric cytosine 5‐modifications in DNA are selectively recognized by the nuclear proteome. Using promoter probes with defined modification patterns, we identify tissue‐specific reader proteinsincluding MYC, MAX, and RFX5that discriminate 5‐hydroxymethylcytosine symmetry and sequence ...
Lena Engelhard, Zeyneb Vildan Cakil, Marlon S. Zambrano‐Mila, Simone Eppmann, Tye Gonzalez, Rasmus Linser, Petra Janning, Sidney Becker, Daniel Summerer   +8 more
wiley   +1 more source

Determination of 8-hydroxy-2'-deoxyguanosine in urine by UHPLC-MS/MS

Zhiye weisheng yu yingji jiuyuan
Objective To establish a ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/ MS) method for the detection of 8-hydroxy-2'-deoxyguanosine in urine, providing methodological support for the quantitative assessment of DNA ...
ZHAO Tengwen
doaj   +1 more source

Plasma total antioxidant capacity and peroxidation biomarkers in psoriasis [PDF]

, 2016
Systemic biomarkers of oxidative stress can be relevant for assessment of psoriasis severity, for prediction of the outcome of therapy and of the development of comorbidities.
Cavaliere, Arturo, Palmery, Maura, Peluso, Ilaria   +2 more
core   +2 more sources