Results 81 to 90 of about 23,028 (215)

Nano‐networks via reaction‐induced self‐assembly coordinate spatiotemporal multi‐drug delivery for acute kidney injury therapy

BMEMat, EarlyView.
Multifunctional nano‐networks (NNWs) are prepared via reaction‐induced self‐assembly (RISA) of spermidine (SPD), epigallocatechin gallate (EGCG), 2‐formylphenylboronic acid (2‐FPBA), and deferoxamine (DFO) through dynamic iminoboronate bonds. These NNWs leverage the oxidative AKI microenvironment to trigger disintegration, enabling site‐specific ...
Juan Jin, Xiao Zhang, Chenxi Wang, Taian Jin, Xinyang Fang, Yixuan Gao, Mengchun Chen, Weiyang Meng, Chang Gao, Wenlu Li, Yuanfeng Li, Yijie Chen, Calvin A. Omolo, Thirumala Govender, Linqi Shi, Yunguang Wang, Yong Liu, Qiang He   +17 more
wiley   +1 more source

Anthocyanin supplementation improves anti-oxidative and anti-inflammatory capacity in a dose–response manner in subjects with dyslipidemia

Redox Biology, 2020
Background: Anthocyanins, one of the major plant bioactive substances, possess anti-oxidative and anti-inflammatory capacity. However, their dose–response relationship has remained unclear. The present study investigated the dose–response relationship of
Hanyue Zhang, Zhongliang Xu, Huiwen Zhao, Xu Wang, Juan Pang, Qing Li, Yan Yang, Wenhua Ling   +7 more
doaj   +1 more source

Blood 8-hydroxy-2'-deoxyguanosine is associated with erythropoietin resistance in haemodialysis patients [PDF]

Nephrology Dialysis Transplantation, 2003
8-Hydroxy-2'-deoxyguanosine (8-OHdG), a product of oxidized DNA, is increased in haemodialysis (HD) patients, but the clinical relevance of enhanced 8-OHdG production in these patients remains unknown.We cross-sectionally measured serum 8-OHdG in 73 patients on maintenance HD (age 68+/-2 years, time on HD 85+/-11 months, male/female=42/31), and ...
Akihiko, Kato, Mari, Odamaki, Akira, Hishida   +2 more
openaire   +2 more sources

DNA catabolites in triathletes: effects of supplementation with an aronia–citrus juice (polyphenols-rich juice) [PDF]

, 2016
In this study we analyzed whether our aronia–citrus juice (ACJ, the composition is based on a mixture of 95% citrus juice with 5% of Aronia melanocarpa juice), rich in polyphenols, and physical exercise had an effect on seven catabolites of DNA ...
Abellán, Ángel, Cejuela, Roberto, Ferreres, Federico, García-Flores, Libia Alejandra, Genieser, Hans-Gottfried, Gil-Izquierdo, Ángel, Martínez Sanz, José Miguel, Medina, Sonia   +7 more
core   +2 more sources

Nanogel‐Mediated Immunotherapy to Tackle Cancer and Inflammatory Diseases

ChemistryEurope, EarlyView.
Nanogels formed through self‐assembly, microemulsion, or precipitation polymerization method enable precise delivery of immunotherapeutic factors and immune cell targeting, thus effectively modulating immune responses. This review highlights recent advances in stimuli‐responsive nanogel design, underlying mechanisms, and their potentials to tackle ...
Ziwen Zhang, Jinxia Wang, Guang‐Zhi Jin, István Bányai, Dzmitry Shcharbin, Ivan Stoikov, Mingwu Shen, Xiangyang Shi   +7 more
wiley   +1 more source

Morphological Transformation by 8-Hydroxy-2'-deoxyguanosine in Syrian Hamster Embryo (SHE) Cells [PDF]

Toxicological Sciences, 2000
8-Hydroxy-2'-deoxyguanosine (OH8dG) is one of the most prevalent oxidative DNA modifications found in eukaryotic cells. Previous studies have suggested an association between OH8dG formation and carcinogenesis. However, it is unclear whether OH8dG formation results in the necessary genotoxic events for cancer development.
H, Zhang, Y, Xu, L M, Kamendulis, J E, Klaunig   +3 more
openaire   +2 more sources

Engineered Metal–Organic Frameworks‐Based Materials for Environmental Detection

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Engineered metal–organic frameworks (MOFs) regulated by various material modification strategies are discussed for environmental contaminant detection under different sensing mechanisms, providing future improvements of MOFs in environmental detection. Sensitive and selective detection of contaminants is crucial for environmental protection.
Pan Gao, Song Wang, Yuechao Yao, Yibo Dou   +3 more
wiley   +1 more source

Assessment of oxidative damage to proteins and DNA in urine of newborn infants by a validated UPLC-MS/MS approach [PDF]

, 2014
The assessment of oxidative stress is highly relevant in clinical Perinatology as it is associated to adverse outcomes in newborn infants. This study summarizes results from the validation of an Ultra Performance Liquid Chromatography-tandem Mass ...
Asensi, M. (Miguel), Cubells, E. (Elena), Escobar, J.J. (Javier), Goudoever, J.B. (Hans) van, Kuligowski, J. (Julia), Lliso, I. (Isabel), Nuñez, A. (Antonio), Quintás, G. (Guillermo), Rook, D. (Denise), Torres-Cuevas, I. (Isabel), Vento, M. (Maximo)   +10 more
core   +1 more source

Endometrial Stromal Cell Senescence: A Non‐Negligible Factor in Recurrent Pregnancy Loss

iMetaMed, EarlyView.
As populations age, links between female reproductive aging and infertility are increasingly evident. Cellular senescence, characterized by near‐irreversible cell‐cycle arrest and accumulation of damage, can impair tissue function. In the endometrium, aberrant senescence of endometrial stromal cells (EnSCs) may compromise receptivity, hinder embryo ...
Shuang Wu, Cenlan Bu, Qinzheng Xu, Xi Cheng, Junrong Zhang, Jinling Chen, Yun‐Zhao Xu   +6 more
wiley   +1 more source

Cholesterol Exchange, DNA Damages, Apoptosis and Necrosis of Blood Cells in Severe Concomitant Injury

Общая реаниматология, 2008
Objective: to study a number of free-radical reactions, the parameters of cholesterol exchange, and the extent of blood cell DNA damages in victims early after concomitant injury. Subjects and methods.
V. V. Moroz, V. I. Reshetnyak, M. Yu. Muravyeva, A. K. Zhanatayev, Yu. V. Marchenkov, A. D. Durnev   +5 more
doaj   +1 more source