Results 161 to 170 of about 1,652 (188)
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Two major metabolites of 8-prenylnaringenin are estrogenic in vitro
The Journal of Steroid Biochemistry and Molecular Biology, 20048-prenylnaringenin (8-PN) and preparations containing 8-prenylnaringenin have been suggested for use in medicinal and cosmetic applications like hormone replacement or bust enhancement. However, the safety of application is still under considerable debate.
Oliver, Zierau +4 more
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Xanthohumol and 8-prenylnaringenin ameliorate diabetic-related metabolic dysfunctions in mice
The Journal of Nutritional Biochemistry, 2017Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by metabolic disturbances in specific tissues. The present work aimed to analyze the effects of xanthohumol (XN) and 8-prenylnaringenin (8PN), two beer-derived polyphenols, in liver and skeletal muscle lipid and glycolytic metabolism in T2DM mice model. Thirty C57Bl/6 mice were randomly
Raquel, Costa +8 more
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Production of 8-Prenylnaringenin from Isoxanthohumol through Biotransformation by Fungi Cells
Journal of Agricultural and Food Chemistry, 20118-Prenylnaringenin (8PN), which presents in hop, enjoys fame as the most potential phytoestrogen. Although a number of health effects are attributed to 8PN, few reports are available about the production of it. In this work, screening of fungi to efficiently transform isoxanthohumol (IXN) into 8PN was designed.
Ming-liang, Fu +6 more
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The phytoestrogen 8-prenylnaringenin inhibits agonist-dependent activation of human platelets
Biochimica et Biophysica Acta (BBA) - General Subjects, 2012Phytoestrogens are plant-derived polyphenolic compounds that exert beneficial effects on human health, mostly related to their estrogen mimetic activity. In particular a strong correlation between phytoestrogens intake and a lower risk of cardiovascular diseases has been reported.
Di Vito C +5 more
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Enantiospecific pharmacokinetics of isoxanthohumol and its metabolite 8‐prenylnaringenin in the rat
Molecular Nutrition & Food Research, 2015ScopeIsoxanthohumol (IX) is a bioactive dietary prenylflavanone found in hops (Humulus lupulusL.), beer and nutraceuticals. IX is formed in vivo by xanthohumol and is a prodrug of 8‐prenylnaringenin (8PN). IX and 8PN chirality has largely been ignored in the literature due to lack of enantiospecific bioanalytical methods. No single dose pharmacokinetic
Stephanie E, Martinez, Neal M, Davies
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8‐prenylnaringenin, a novel phytoestrogen, inhibits angiogenesis in vitro and in vivo
Journal of Cellular Physiology, 2003Abstract8‐Prenylnaringenin is a recently discovered phytoestrogen. Using an in vitro model of angiogenesis in which endothelial cells can be induced to invade a three‐dimensional collagen gel within which they form capillary‐like tubes, we demonstrate that 8‐prenylnaringenin inhibits angiogenesis induced by basic fibroblast growth factor (bFGF ...
Pepper, M. +3 more
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Antiproliferative and apoptotic activities of 8-prenylnaringenin against human colon cancer cells
Life Sciences, 2019The compound 8-prenylnaringenin (8-PN) is a prenylflavonoid that can be isolated from hops and beer and has anti-cancer properties against breast cancer. The aim of this study is to investigate the anti-proliferative and apoptotic activities of 8-PN against human colon cancer HCT-116 cells.Colon cancer HCT-116 cells were treated with 8-PN and subjected
Sanaz Koosha +5 more
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Regulation of Gene Expression by Hop-Derived 8-Prenylnaringenin
2009Abstract Anecdotal stories, structural considerations and findings from in vitro assays suggested that 8-prenylnaringenin (8-PN) contained in the female hop (Humulus lupulus L.) flowers exhibits a strong estrogenic potency. Estrogens act through the two nuclear receptors estrogen receptor-α and -β (ER-α and -β). Hallmark of estrogen action in target
Oliver Zierau, Günter Vollmer
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Planta Medica, 2003
Naturally occurring naringenin derivatives, known for their estrogenic activity, were tested in two independent (anti-)androgen screening assays. Using a yeast-based androgen receptor assay relatively strong antiandrogen activities were demonstrated for 6-(1,1-dimethylallyl)naringenin and 8-prenylnaringenin, while the parent compound naringenin did not
Oliver, Zierau +6 more
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Naturally occurring naringenin derivatives, known for their estrogenic activity, were tested in two independent (anti-)androgen screening assays. Using a yeast-based androgen receptor assay relatively strong antiandrogen activities were demonstrated for 6-(1,1-dimethylallyl)naringenin and 8-prenylnaringenin, while the parent compound naringenin did not
Oliver, Zierau +6 more
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European Journal of Pharmacology, 2010
Flavonoids with hydrophobic e.g. prenyl substituents might constitute the promising candidates for multidrug resistance (MDR) reversal agents. The interaction of 8-prenylnaringenin (8-isopentenylnaringenin), a potent phytoestrogen isolated from common hop (Humulus lupulus), with two multidrug resistance-associated ABC transporters of cancer cells, P ...
Olga, Wesołowska +7 more
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Flavonoids with hydrophobic e.g. prenyl substituents might constitute the promising candidates for multidrug resistance (MDR) reversal agents. The interaction of 8-prenylnaringenin (8-isopentenylnaringenin), a potent phytoestrogen isolated from common hop (Humulus lupulus), with two multidrug resistance-associated ABC transporters of cancer cells, P ...
Olga, Wesołowska +7 more
openaire +2 more sources