Results 171 to 180 of about 1,652 (188)

METABOLISM OF 8-PRENYLNARINGENIN, A POTENT PHYTOESTROGEN FROM HOPS (HUMULUS LUPULUS), BY HUMAN LIVER MICROSOMES

Drug Metabolism and Disposition, 2004
The female flowers of hops are used throughout the world as a flavoring agent for beer. Recently, there has been increasing interest in the potential estrogenic properties of hop extracts. Among the possible estrogenic compounds in hops, 8-prenylnaringenin is perhaps most significant due to its high in vitro potency exceeding that of other known ...
Dejan, Nikolic, Yongmei, Li, Lucas R, Chadwick, Simonida, Grubjesic, Pia, Schwab, Peter, Metz, Richard B, van Breemen   +6 more
openaire   +2 more sources

Structure Determination of Isoxanthohumol and 8-Prenylnaringenin Glucuronides Formed by Human Liver Microsomes

Planta Medica, 2013
Isoxanthohumol (IX) and 8-prenylnaringenin (8-PN) are prenylated flavonoids of hops (Humulus lupulus L.) with estrogenic activity that are under investigation as dietary supplements for the treatment of menopausal symptoms in women. Previous studies suggest a variety of phase I metabolites for IX and 8-PN and some conjugates, but there is less ...
J Fang, D Nikolić, SN Chen, RF Ramos Alvarenga, GF Pauli, RB van Breemen   +5 more
openaire   +1 more source

Determination of the Hop-Derived Phytoestrogen, 8-Prenylnaringenin, in Beer by Gas Chromatography/Mass Spectrometry

Journal of Agricultural and Food Chemistry, 1999
A method was developed to determine 8-prenylnaringenin, a novel hop-derived phytoestrogen, in beer. Matrix purification involved solid-phase extraction on octadecyl silica followed by liquid/liquid extraction on a ChemElut 1010 column connected to a Florisil adsorption/desorption cartridge.
J, Tekel', D, De Keukeleire, H, Rong, E, Daeseleire, C, Van Peteghem   +4 more
openaire   +2 more sources

Regulation of Gene Expression by 8-Prenylnaringenin in Uterus and Liver of Wistar rats

Planta Medica, 2004
The potential estrogenic activity of 8-prenylnaringenin has been investigated using several in vitro test systems. 8-Prenylnaringenin is a natural secondary product of the female blossoms of hops. The aim of the present study was to characterize 8-prenylnaringenin for its estrogenic effects in vivo.
Patrick, Diel, Renate B, Thomae, Antonio, Caldarelli, Oliver, Zierau, Susanne, Kolba, Simone, Schmidt, Pia, Schwab, Peter, Metz, Günter, Vollmer   +8 more
openaire   +2 more sources

Development of a Radioimmunoassay for the Quantitative Determination of 8-Prenylnaringenin in Biological Matrices

Journal of Agricultural and Food Chemistry, 2005
Seven carboxylic acid haptens of 8-prenylnaringenin (8-PN) were synthesized, coupled to cationized bovine serum albumin, and employed to raise specific antisera in rabbits. Two linkers of different lengths (C3H6COOH and C6H12COOH) were coupled to the C7-OH group and separated into their respective enantiomers yielding the first four haptens.
Olaf, Schaefer, Rolf, Bohlmann, Wolf-Dieter, Schleuning, Kai, Schulze-Forster, Michael, Hümpel   +4 more
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USE OF 8-PRENYLNARINGENIN FOR HORMONE REPLACEMENT THERAPY

2005
The invention provides a production method for the phytoestrogen 8-Prenylnaringenin, the preparation produced by this method and the use of 8-Prenylnaringenin for the production of a medicament for the prevention and treatment of hormone-dependent osteoporosis and of peri- and postmenopausal symptoms in women.
SCHERING AG, HUEMPEL MICHAEL, SCHLEUNING WOLF-DIETER, SCHAEFER OLAF, ISAKSSON PAEIVI, BOHLMANN ROLF   +5 more
openaire   +1 more source

Reproductive and Estrogenic Effects of 8-Prenylnaringenin in Hops

2009
Abstract Historical and anecdotal observations of the estrogenic activity of hops led to the identification of 8-prenylnaringenin (8PN) as one of the most potent phyto-oestrogens. As an estrogen, 8PN has the potential to interact with the estrogen-signaling systems within the body, including the reproductive system. In terms of normal exposure, only
openaire   +1 more source

MICROBIAL AND DIETARY FACTORS ASSOCIATED WITH THE EQUOL AND 8-PRENYLNARINGENIN PRODUCER PHENOTYPES

Acta Horticulturae, 2009
The importance of the gut microbiota in the phyto-oestrogen bioavailability and bioactivity has been convincingly demonstrated in vitro and in vivo. Equol, a microbial metabolite of the soy isoflavone daidzein, is more bioactive than its precursor, and has been hypothesized as a clue to the effectiveness of soy and its isoflavones.
S. Bolca, S. Possemiers, W. Verstraete, T. Van de Wiele, A. Heyerick, D. De Keukeleire, I. Huybrechts, S. De Henauw, H. Depypere, M. Bracke   +9 more
openaire   +1 more source

Estrogenic Activity of the Phytoestrogens Naringenin, 6-(1,1-Dimethylallyl)naringenin and 8-Prenylnaringenin

Planta Medica, 2002
Chemically synthesized naringenin derivatives, identical to natural occurring compounds, were tested for their estrogenic activity using two independent estrogen screening assays. Using a yeast based estrogen receptor assay, strong estrogenic activities were demonstrated for 6-(1,1-dimethylallyl)naringenin and 8-prenylnaringenin, while the parent ...
Oliver Zierau, Sven Gester, Pia Schwab, Peter Metz, Susanne Kolba, Marina Wulf, Günter Vollmer   +6 more
openaire   +1 more source

Behavioral and Neuroprotective Properties of the Phytoestrogen 8‐Prenylnaringenin (8‐PN) in Ovariectomized Mice

Phytotherapy Research
ABSTRACT8‐Prenylnaringenin (8‐PN) is one of the most potent phytoestrogens identified to date. Despite its role as an estrogen receptor modulator and its vast therapeutic potential, the effects of this molecule on the brain and behavior of females remain largely unexplored.
Igor Ferraz da Silva, Celina D’Ávila Felipe, Alexandre Dantas Alves, Pollyana Peixoto, Lívia Carla de Melo Rodrigues   +4 more
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