Results 21 to 30 of about 1,652 (188)

Preparation of Hop Estrogen-Active Material for Production of Food Supplements

Molecules, 2021
In recent years, the interest in the health-promoting effects of hop prenylflavonoids, especially its estrogenic effects, has grown. Unfortunately, one of the most potent phytoestrogens identified so far, 8-prenylnaringenin, is only a minor component of ...
Marcel Karabín, Tereza Haimannová, Kristýna Fialová, Lukáš Jelínek, Pavel Dostálek   +4 more
doaj   +1 more source

Reductive Metabolism of Xanthohumol and 8-Prenylnaringenin by the Intestinal Bacterium Eubacterium ramulus. [PDF]

Mol Nutr Food Res, 2019
ScopeThe intestinal microbiota transforms a wide range of available substrates, including polyphenols. Microbial catabolites of polyphenols can contribute in significant ways to the health‐promoting properties of their parent polyphenols. This work aims to identify intestinal metabolites of xanthohumol (XN), a prenylated flavonoid found in hops ...
Paraiso IL, Plagmann LS, Yang L, Zielke R, Gombart AF, Maier CS, Sikora AE, Blakemore PR, Stevens JF.   +8 more
europepmc   +4 more sources

Effect of Structural Differences in Naringenin, Prenylated Naringenin, and Their Derivatives on the Anti-Influenza Virus Activity and Cellular Uptake of Their Flavanones

Pharmaceuticals, 2022
Vaccines and antiviral drugs are widely used to treat influenza infection. However, they cannot rapidly respond to drug-resistant viruses. Therefore, new anti-influenza virus strategies are required.
Ryosuke Morimoto, Chiaki Matsubara, Akari Hanada, Yuta Omoe, Tokutaro Ogata, Yuji Isegawa   +5 more
doaj   +1 more source

Synthetic production of prenylated naringenins in yeast using promiscuous microbial prenyltransferases

Metabolic Engineering Communications, 2021
Reconstitution of prenylflavonoids using the flavonoid biosynthetic pathway and prenyltransferases (PTs) in microbes can be a promising attractive alternative to plant-based production or chemical synthesis.
Shota Isogai, Nobuyuki Okahashi, Ririka Asama, Tomomi Nakamura, Tomohisa Hasunuma, Fumio Matsuda, Jun Ishii, Akihiko Kondo   +7 more
doaj   +1 more source

Formation of (2R)- and (2S)-8-Prenylnaringenin Glucuronides by Human UDP-Glucuronosyltransferases. [PDF]

J Agric Food Chem, 2019
Occurring in hops (Humulus lupulus) and beer as a racemic mixture, (2R,2S)-8-prenylnaringenin (8-PN) is a potent phytoestrogen in hop dietary supplements used by women as alternatives to conventional hormone therapy. With a half-life exceeding 20 h, 8-PN is excreted primarily as 8-PN-7-O-glucuronide or 8-PN-4'-O-glucuronide.
Fang JB, Nikolić D, Lankin DC, Simmler C, Chen SN, Ramos Alvarenga RF, Liu Y, Pauli GF, van Breemen RB.   +8 more
europepmc   +4 more sources

Chemoprotective Effects of Xanthohumol against the Carcinogenic Mycotoxin Aflatoxin B1

Foods, 2021
The present study addresses the chemoprotective effects of xanthohumol (XN), a prenylated flavonoid found in the female inflorescences (hops) of the plant Humulus lupulus L., against the carcinogenic food contaminant aflatoxin B1 (AFB1).
Alja Štern, Veronika Furlan, Matjaž Novak, Martina Štampar, Zala Kolenc, Katarina Kores, Metka Filipič, Urban Bren, Bojana Žegura   +8 more
doaj   +1 more source

Identification of Antioxidant, Antimicrobial, and Cytotoxic Compounds From Hymenocardia acida Tul. Using Ultra-High-Performance Liquid Chromatography-Quadrupole Exactive-Orbitrap-Mass Spectrometry and Molecular Networking Approach. [PDF]

Chem Biodivers
ABSTRACT Hymenocardia acida Tul. is a medicinal plant used in Angola to treat microbial diseases. It is a well‐known plant among local populations; however, few studies have focused on the assessment of phytochemicals associated with their biological activities.
Malebo NJ, Manduna IT, Mawunu M, Chokwe RC, Tlhapi B.   +4 more
europepmc   +2 more sources

Evaluation of estrogenic activity of licorice species in comparison with hops used in botanicals for menopausal symptoms. [PDF]

PLoS ONE, 2013
The increased cancer risk associated with hormone therapies has encouraged many women to seek non-hormonal alternatives including botanical supplements such as hops (Humulus lupulus) and licorice (Glycyrrhiza spec.) to manage menopausal symptoms ...
Atieh Hajirahimkhan, Charlotte Simmler, Yang Yuan, Jeffrey R Anderson, Shao-Nong Chen, Dejan Nikolić, Birgit M Dietz, Guido F Pauli, Richard B van Breemen, Judy L Bolton   +9 more
doaj   +1 more source

Brewers’ spent hop revalorization for the production of high added-value cosmetics ingredients with elastase inhibition capacity

Scientific Reports, 2022
This article summarizes the analysis of α and β-acids and prenylflavonoids from brewers’ spent hop (BSH) as source of bioactive molecules to improve skin integrity by inhibiting elastase activity.
Maria Paredes-Ramos, Enma Conde Piñeiro, Jose M. Lopez Vilariño   +2 more
doaj   +1 more source

Co-Application of Statin and Flavonoids as an Effective Strategy to Reduce the Activity of Voltage-Gated Potassium Channels Kv1.3 and Induce Apoptosis in Human Leukemic T Cell Line Jurkat

Molecules, 2022
Voltage-gated potassium channels of the Kv1.3 type are considered a potential new molecular target in several pathologies, including some cancer disorders and COVID-19.
Andrzej Teisseyre, Mateusz Chmielarz, Anna Uryga, Kamila Środa-Pomianek, Anna Palko-Łabuz   +4 more
doaj   +1 more source