Results 11 to 20 of about 173,591 (312)

Intra-accumbens injection of a dopamine aptamer abates MK-801-induced cognitive dysfunction in a model of schizophrenia. [PDF]

PLoS ONE, 2011
Systemic administration of the noncompetitive NMDA-receptor antagonist, MK-801, has been proposed to model cognitive deficits similar to those seen in patients with schizophrenia.
Matthew R Holahan, Dan Madularu, Erin M McConnell, Ryan Walsh, Maria C DeRosa   +4 more
doaj   +1 more source

Ultrasound-Assisted Synthesis of Defective MOF-801 for the Adsorptive Removal of Cationic Dyes [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2023
Defective MOF-801 (Zirconium-fumarate metal-organic framework) was de novo synthesized using environmentally friendly ultrasound-assisted synthesis. The effect of the modulator on the crystallinity, morphology, density of missing linkers, pore volume ...
Kiran Kumar Penmethsa, Satya Veni Sunkara   +1 more
doaj   +1 more source

Reversible Changes in BDNF Expression in MK-801-Induced Hippocampal Astrocytes Through NMDAR/PI3K/ERK Signaling

Frontiers in Cellular Neuroscience, 2021
Dizocilpine (MK-801), a non-competitive N-methyl-D-aspartic acid receptor (NMDA-R) antagonist, can induce schizophrenia-like symptoms in healthy individuals, implicating NMDA-R hypofunction in disease pathogenesis. Brain-derived neurotrophic factor (BDNF)
Wenjuan Yu, Hongwei Fang, Lei Zhang, Miaowen Hu, Sidi He, Huafang Li, Huafang Li, Huafang Li, Hao Zhu   +8 more
doaj   +1 more source

Effect of Neonatal Treatment With the NMDA Receptor Antagonist, MK-801, During Different Temporal Windows of Postnatal Period in Adult Prefrontal Cortical and Hippocampal Function

Frontiers in Behavioral Neuroscience, 2021
The neonatal MK-801 model of schizophrenia has been developed based on the neurodevelopmental and NMDA receptor hypofunction hypotheses of schizophrenia.
Maria E. Plataki, Maria E. Plataki, Konstantinos Diskos, Konstantinos Diskos, Christos Sougklakos, Marouso Velissariou, Alexandros Georgilis, Vasiliki Stavroulaki, Kyriaki Sidiropoulou, Kyriaki Sidiropoulou   +9 more
doaj   +1 more source

Crocin alleviates schizophrenia-like symptoms in rats by upregulating silent information regulator-1 and brain derived neurotrophic factor

Comprehensive Psychiatry, 2020
Background: In neonatal rats, MK-801 treatments can produce schizophrenia-like symptoms. Crocin is a water soluble carotenoid in Saffron that exerts potent neuroprotective effects.
Xi-juan Sun, Xin Zhao, Jun-ning Xie, Hao Wan   +3 more
doaj   +1 more source

Comparison of a Resonant Mirror Biosensor (IAsys) and a Quartz Crystal Microbalance (QCM) for the Study on Interaction between Paeoniae Radix 801 and Endothelin-1

Sensors, 2008
A resonant mirror biosensor, IAsys, and a quartz crystal microbalance (QCM) are known independently as surface sensitive analytical devices capable of label-free and in situ bioassays. In this study, an IAsys and a QCM are employed for a new study on the
Tetsuo Osa, Huijun Yin, Liang Yuan, Xiaorui He, Xiuming Zhang, Xinsheng Wang, Zixia Zhao, Min Yu, Jing Li, Qing Lin, Jiadong Huang, Jinghua Yu, Shenguang Ge, Keji Chen, Qiang Chen   +14 more
doaj   +1 more source

Sensorimotor Gating Impairments Induced by MK-801 Treatment may be Reduced by Tolerance Effect and by Familiarization in Monkeys

Frontiers in Pharmacology, 2015
Dizocilpine (MK-801) is a noncompetitive NMDA antagonist that induces schizophrenic-like effects. It is therefore widely used in experimental models of schizophrenia including prepulse inhibition (PPI) impairments in rodents.
Patricia G Saletti, Rafael S Maior, Etsuro eHori, Hisao eNishijo, Carlos eTomaz, Carlos eTomaz   +5 more
doaj   +1 more source

Increased inhibitory input to CA1 pyramidal cells alters hippocampal gamma frequency oscillations in the MK-801 model of acute psychosis

Neurobiology of Disease, 2007
The phencyclidine compound MK-801 can induce psychosis with symptoms which closely resemble those observed in an acute schizophrenic episode. Here we used an in vitro model of psychosis after systemic administration of MK-801.
Colin Kehrer, Tamar Dugladze, Nino Maziashvili, Anna Wójtowicz, Dietmar Schmitz, Uwe Heinemann, Tengis Gloveli   +6 more
doaj   +1 more source

Frequency-specific medial septal nucleus deep brain stimulation improves spatial memory in MK-801-treated male rats

Neurobiology of Disease, 2022
Background: Few treatments exist for the cognitive symptoms of schizophrenia. Pharmacological agents resulting in glutamate N-methyl-d-aspartate (NMDA) receptor hypofunction, such as MK-801, mimic many of these symptoms and disrupt neural activity ...
Nancy C. Zepeda, Lindsey M. Crown, Sasha Medvidovic, Wooseong Choi, Megha Sheth, Matthew Bergosh, Raymond Gifford, Caroline Folz, Phillip Lam, Gengxi Lu, Robert Featherstone, Charles Y. Liu, Steven J. Siegel, Darrin J. Lee   +13 more
doaj   +1 more source

European multicentre study on outcome of surgery for sporadic primary hyperparathyroidism

BJS (British Journal of Surgery), EarlyView., 2020
Some 5861 patients undergoing first‐time surgery for sporadic primary hyperparathyroidism were registered in the Eurocrine® database between 2015 and 2018. The use of intraoperative parathyroid hormone measurement decreased the risk of conversion and persistent hypercalcaemia.
A. Bergenfelz, S. van Slycke, Ö. Makay, L. Brunaud   +3 more
wiley   +1 more source