Results 71 to 80 of about 985,419 (304)
Advanced Science, EarlyView.The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi +13 more
wiley +1 more source
Frontiers in Pharmacology, 2013 Antagonism of N-methyl-D-aspartate (NMDA) receptors by phencyclidine is thought to underlie its ability to induce a schizophrenia-like syndrome in humans, yet evidence indicates it has a broader pharmacological profile.
Wendy K Adams +3 more
doaj +1 more source
Universal approximation of multi-copy states and universal quantum lossless data compression
, 2008 We have proven that there exists a quantum state approximating any multi-copy state universally when we measure the error by means of the normalized relative entropy. While the qubit case was proven by Krattenthaler and Slater (IEEE Trans.
B. Schumacher +15 more
core +1 more source
Relationships between hornblende K-Ar ages, chemical composition and hydrogen isotopes, Connemara, western Ireland: evidence for a massive extinct hydrothermal system [PDF]
, 2001 Major element compositional analyses, K-Ar ages, deltaD parts per thousand and delta O-18 parts per thousand values for 30 zoned and unzoned hornblendes from Dalradian amphibolites and metagabbros. mostly in north Connemara are reported.
Fallick, A.E., Jappy, T.G., Leake, B.E.
core +1 more source
Advanced Science, EarlyView.A central molecular adaptor, ZSL, is identified that links transverse filaments ZYP1 to central element SCEP1/2 to drive synaptonemal complex assembly in Brassica napus. Loss of ZSL abolishes synaptonemal complex formation, disrupts meiotic chromosome segregation, and markedly increases crossovers, providing mechanistic insight into meiotic fidelity ...
Miaowei Geng +16 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2015 As a multifactorial disease, the underlying causes of schizophrenia require analysis by multiplex methods such as proteomics to allow identification of whole protein networks.
Paul C Guest +6 more
doaj +1 more source
Kondo Effect and Josephson Current through a Quantum Dot between Two Superconductors
, 2004 We investigate the supercurrent through a quantum dot for the whole range of couplings using the numerical renormalization group method. We find that the Josephson current switches abruptly from a $\pi$- to a 0-phase as the coupling increases.
Kicheon Kang +7 more
core +1 more source
Pre-training in a radial arm maze abolished anxiety and impaired habituation in C57BL6/J mice treated with dizocilpine [PDF]
, 2016 Familiarity can imply a reduction of fear and anxiety, which may render learning and memory performance insensitive to NMDA receptor antagonism. Our previous study indicates that MK-801 (dizocilpine), NMDA antagonist, increased anxiety and prevented the ...
Abuhamdah, R.M. +3 more
core +1 more source
DNA Nanoarray for Multiplexed RNA Detection With Single‐Molecule Readout
Advanced Science, EarlyView.A carrier‐based DNA nanoarray integrates programmable nucleic acid hybridization with solid‐state nanopore readout for direct RNA detection at single‐molecule resolution. A ternary encoding system enables 27 carriers with 81 addressable sensing sites, allowing the simultaneous identification of targets spanning a wide size range, from short microRNAs ...
Yunxuan Li +12 more
wiley +1 more source
Psychiatry and Clinical Psychopharmacology, 2018 OBJECTIVES Nicotinic receptor systems are involved in a wide variety of behavioural functions, including cognitive function, and nicotinic medications, may provide beneficial treatment for cognitive dysfunctions such as schizophrenia.
Gokhan Unal, Feyza Aricioglu
doaj +1 more source